Substrates for peptidase C14.018: caspase-14

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
26S proteasome complex subunit DSS1	P60896	1-70	peptide-Asp46+Asn-peptide	P	MS	Trp	Asp	Asp	Asp	Asn	Val	Glu	Asp
Ac-Ile-Glu-Thr-Asp-AFC			Ac-Ile-Glu-Thr-Asp+AFC	S		Ile	Glu	Thr	Asp	AFC	-	-	-	Mikolajczyk et al., 2004
Ac-Leu-Glu-His-Asp-AFC			Ac-Leu-Glu-His-Asp+AFC	S		Leu	Glu	His	Asp	AFC	-	-	-	Mikolajczyk et al., 2004
Ac-Trp-Glu-His-Asp-AFC			Ac-Trp-Glu-His-Asp+AFC	S		Trp	Glu	His	Asp	AFC	-	-	-	Mikolajczyk et al., 2004
Bcl-2-associated transcription factor 1	Q9NYF8	1-920	peptide-Asp895+Gly-peptide	P	MS	Tyr	Gln	Gly	Asp	Gly	Ile	Val	Glu
BH3-interacting domain death agonist (BID)	P70444	1-75	peptide-Asp59+Gly-peptide	N		Leu	Gln	Thr	Asp	Gly	Ser	Gln	Ala	Mikolajczyk et al., 2004
DNA topoisomerase 1	P11387	2-765	peptide-Asp9+Ser-peptide	P	MS	Leu	His	Asn	Asp	Ser	Gln	Ile	Glu
Early 35 kDa protein (Cys2Ala mutant)	P08160	1-299	peptide-Asp87+Gly-peptide	N		Asp	Gln	Met	Asp	Gly	Phe	His	Asp	Mikolajczyk et al., 2004
Endoplasmin	P14625	22-803	peptide-Asp28+Gly-peptide	P	MS	Val	Asp	Val	Asp	Gly	Thr	Val	Glu
Eukaryotic translation initiation factor 3 subunit J	O75822	2-258	peptide-Asp17+Ala-peptide	P	MS	Trp	Asp	Ala	Asp	Ala	Phe	Ser	Val
Eukaryotic translation initiation factor 4B	P23588	1-611	peptide-Asp531+Gly-peptide	P	MS	Asn	Lys	Val	Asp	Gly	Met	Asn	Ala
Heat shock protein HSP 90-beta	P08238	2-724	peptide-Asp706+Glu-peptide	P	MS	Ala	Val	Pro	Asp	Glu	Ile	Pro	Pro
Leucine-rich repeat flightless-interacting protein 1	Q32MZ4	2-808	peptide-Asp673+Gly-peptide	P	MS	Val	Leu	Ala	Asp	Gly	Asp	Thr	Leu
Nucleolar RNA helicase 2	Q9NR30	1-783	peptide-Asp8+Ala-peptide	P	MS	Leu	Arg	Ser	Asp	Ala	Gly	Leu	Glu
Putative heat shock protein HSP 90-beta-3	Q58FF7	1-597	peptide-Asp579+Glu-peptide	P	MS	Ala	Val	Pro	Asp	Glu	Ile	Pro	Pro
Thyroid hormone receptor-associated protein 3	Q9Y2W1	1-955	peptide-Asp391+Ser-peptide	P	MS	Met	Lys	Ser	Asp	Ser	Phe	Ala	Pro
Zinc finger CCCH domain-containing protein 4	Q9UPT8	1-1303	peptide-Asp67+Gly-peptide	P	MS	Leu	Glu	Asp	Asp	Gly	Ala	Glu	Glu