Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P11387

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-765	P		NT	<%Agarwal et al., 2012[]%>
15	granzyme B (Homo sapiens-type)	1-765	P			Casciola-Rosen et al., 1999
123	caspase-3	2-765	P		CS	Ju et al., 2007
123	caspase-6	1-765	P			Samejima et al., 1999
146	caspase-3	1-765	P			Samejima et al., 1999
170	caspase-3	1-765	P			Samejima et al., 1999
170	caspase-6	1-765	P			Samejima et al., 1999
258	matrix metallopeptidase-2	255-267	N		MS	Schilling & Overall, 2008
267	glutamyl endopeptidase I	1-765	N		MS	Schilling & Overall, 2008
528	granzyme B (Homo sapiens-type)	2-765	N		MS	Van Damme et al., 2010