Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O75822

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-258	P		NT	<%Agarwal et al., 2012[]%>
15	unknown peptidase	1-258	P		MS	Van Damme et al., 2005
17	caspase-1	2-258	N		MS	Agard et al., 2010
17	granzyme B (Homo sapiens-type)	2-258	N		MS	Van Damme et al., 2010
37	granzyme B (Homo sapiens-type)	2-258	N		MS	Van Damme et al., 2010
68	granzyme B (Homo sapiens-type)	2-258	N		MS	Van Damme et al., 2010
100	meprin alpha subunit	2-258	N		MS	Becker-Pauly et al., 2011
100	meprin beta subunit	2-258	N		MS	Becker-Pauly et al., 2011
106	trypsin 1	2-258	N		MS	Schilling & Overall, 2008
117	trypsin 1	2-258	N		MS	Schilling & Overall, 2008
139	unknown peptidase	2-258	P			Van Damme et al., 2009
153	trypsin 1	2-258	N			Van Damme et al., 2009
242	caspase-3	2-258	P			Bushell et al., 2000
256	caspase-3	2-258	P			Bushell et al., 2000