Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence Q9Y2W1

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-955	P	release of an initiating methionine	MS	Van Damme P et al., 2005
218	glutamyl endopeptidase I	215-235	N		MS	Schilling & Overall, 2008
225	granzyme B (Homo sapiens-type)	1-955	N		MS	Van Damme et al., 2010
235	granzyme A	1-955	N			Van Damme et al., 2010
235	trypsin 1	1-955	N		MS	Schilling & Overall, 2008
328	cathepsin G	319-346	N		MS	Schilling & Overall, 2008
346	trypsin 1	1-955	N		MS	Schilling & Overall, 2008
347	trypsin 1	1-955	N		MS	Schilling & Overall, 2008
391	granzyme B (Homo sapiens-type)	1-955	N		MS	Van Damme et al., 2010
473	HIV-1 retropepsin	470-483	N		MS	Schilling & Overall, 2008
483	trypsin 1	1-955	N		MS	Schilling & Overall, 2008
572	granzyme A	1-955	N			Van Damme et al., 2010
574	granzyme B (Homo sapiens-type)	1-955	N		MS	Plasman et al., 2011
849	cathepsin L	846-862	N		MS	Biniossek et al., 2011