$VAR1 = undef;

Summary for peptidase C14.018: caspase-14

Names
MEROPS Name	caspase-14
Other names	mini-ICE, MICE

Domain architecture

MEROPS Classification
Classification	Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.018
Holotype	caspase-14 (Homo sapiens), Uniprot accession P31944 (peptidase unit: 1-242), MERNUM MER0012083
History	Identifier created: MEROPS 3.1 (22 December 1998)

Activity
Catalytic type	Cysteine
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: active (Fischer et al., 2004) mouse: active (Mikolajczyk et al., 2004)
Physiology	'Caspase-14 has been implicated in the formation of stratum corneum because of its specific expression and activation in terminally differentiating keratinocytes' (Alibardi et al., 2004).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Caspase_14
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	l/e/-/Dgaes/-/-/ep (based on 17 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	1	0	7	1	0	0
Pro	0	0	2	0	0	0	2	3
Ala	2	0	2	0	2	1	1	2
Val	2	2	2	0	0	1	2	1
Leu	5	1	0	0	0	0	1	1
Ile	1	0	0	0	0	3	1	0
Met	1	0	1	0	0	1	0	0
Phe	0	0	0	0	0	3	0	0
Tyr	1	0	0	0	0	0	0	0
Trp	3	0	0	0	0	0	0	0
Ser	0	0	2	0	2	1	1	0
Thr	0	0	2	0	0	1	1	0
Cys	0	0	0	0	0	0	0	0
Asn	1	0	1	0	1	0	1	0
Gln	0	3	0	0	0	1	1	0
Asp	1	3	2	17	0	1	0	2
Glu	0	4	0	0	2	0	2	5
Lys	0	2	0	0	0	0	0	0
Arg	0	1	0	0	0	0	0	0
His	0	1	2	0	0	0	1	0