Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P23588

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-611	P	release of an initiating methionine	MS	Van Damme P et al., 2005
45	caspase-3	1-611	P			Bushell et al., 2000
92	trypsin 1	1-611	N		MS	Schilling & Overall, 2008
113	trypsin 1	1-611	N		MS	Schilling & Overall, 2008
206	granzyme B (Homo sapiens-type)	1-611	N		MS	Van Damme et al., 2010
271	unknown peptidase	1-611	P		MS	Van Damme et al., 2005
339	granzyme A	1-611	N			n
356	trypsin 1	1-611	N		MS	Schilling & Overall, 2008
358	meprin alpha subunit	1-611	N		MS	Becker-Pauly et al., 2011
362	cathepsin L	357-372	N		MS	Biniossek et al., 2011
372	trypsin 1	1-611	N		MS	Schilling & Overall, 2008
511	trypsin 1	1-611	N		MS	Schilling & Overall, 2008
524	trypsin 1	1-611	N		MS	Schilling & Overall, 2008
531	caspase-3	1-611	P		MS	Impens et al., 2010