Structure for peptidase C01.075: cruzipain

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
2AIM	Trypanosoma cruzi	2.20 Å	catalytic domain; complex with Bz-Arg-Ala-fluoromethylketone
Catalytic residues are shown in ball-and-stick representation: Cys147 in yellow, His284 in purple and Asn304 in pink. Bound inhibitor is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Trypanosoma cruzi
catalytic domain, Gly213 stop.	2.00 Å	1AIM	1AIM	1AIM	1AIM	1AIM	1AIM	Gillmor et al., 1997
complex with WRR-99	2.00 Å	1EWL	1EWL	1EWL	1EWL	1EWL	1EWL
complex with WRR-112	2.00 Å	1EWM	1EWM	1EWM	1EWM	1EWM	1EWM
complex with WRR-204	2.10 Å	1EWO	1EWO	1EWO	1EWO	1EWO	1EWO
complex with N-carbonylmorpholine-Leu-homophenylalanylmethane inhibitor	1.75 Å	1EWP	1EWP	1EWP	1EWP	1EWP	1EWP
complex with vinyl sulfone-derived inhibitor VS1	2.15 Å	1F29	1F29	1F29	1F29	1F29	1F29	Brinen et al., 2000
complex with vinyl sulfone-derived inhibitor VS2	1.60 Å	1F2A	1F2A	1F2A	1F2A	1F2A	1F2A	Brinen et al., 2000
complex with vinyl sulfone-derived inhibitor VS3	1.80 Å	1F2B	1F2B	1F2B	1F2B	1F2B	1F2B	Brinen et al., 2000
complex with vinyl sulfone-derived inhibitor VS4	2.00 Å	1F2C	1F2C	1F2C	1F2C	1F2C	1F2C	Brinen et al., 2000
complex with [1-(3-hydroxy-2-oxo-1-phenethyl-propylcarbamoyl)2-phenyl-ethyl]-carbamic acid pyridin-4-ylmethyl ester	1.20 Å	1ME3	1ME3	1ME3	1ME3	1ME3	1ME3	Huang et al., 2003
complex with [1-(1-benzyl-3-hydroxy-2-oxo-propylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester	1.20 Å	1ME4	1ME4	1ME4	1ME4	1ME4	1ME4	Huang et al., 2003
complex with [1-(1-methyl-4,5-dioxo-pent-2-enylcarbamoyl)-2-phenyl-ethyl]-carbamic acid benzyl ester	2.30 Å	1U9Q	1U9Q	1U9Q	1U9Q	1U9Q	1U9Q	Choe et al., 2005
catalytic domain; complex with Bz-Arg-Ala-fluoromethylketone	2.20 Å	2AIM	2AIM	2AIM	2AIM	2AIM	2AIM	Gillmor et al., 1997
complex with vinyl sulfone derived inhibitor WR483	1.50 Å	2EFM	2EFM	2EFM	2EFM	2EFM	2EFM
complex with the vinyl sulfone derived inhibitor K11777	1.95 Å	2OZ2	2OZ2	2OZ2	2OZ2	2OZ2	2OZ2	Kerr et al., 2009
mature peptidase	1.75 Å	3HD3	3HD3	3HD3	3HD3	3HD3	3HD3	Bryant et al., 2009
mature peptidase	1.10 Å	3I06	3I06	3I06	3I06	3I06	3I06	Mott et al., 2010
mature peptidase	1.20 Å	3IUT	3IUT	3IUT	3IUT	3IUT	3IUT	Brak et al., 2010
mature peptidase	1.28 Å	3KKU	3KKU	3KKU	3KKU	3KKU	3KKU	Ferreira et al., 2010
mature peptidase	1.50 Å	3LXS	3LXS	3LXS	3LXS	3LXS	3LXS	Chen et al., 2010
mature peptidase	2.62 Å	4KLB	4KLB	4KLB	4KLB	4KLB	4KLB	Wiggers et al., 2013
mature peptidase	1.27 Å	4PI3	4PI3	4PI3	4PI3	4PI3	4PI3	Jones et al., 2016
mature peptidase	3.13 Å	4QH6	4QH6	4QH6	4QH6	4QH6	4QH6	Avelar et al., 2015
mature peptidase	2.70 Å	4W5B	4W5B	4W5B	4W5B	4W5B	4W5B
mature peptidase	3.27 Å	4W5C	4W5C	4W5C	4W5C	4W5C	4W5C
mature peptidase	2.51 Å	4XUI	4XUI	4XUI	4XUI	4XUI	4XUI	Jones et al., 2016
apo-form	1.19 Å	6N3S	6N3S	6N3S	6N3S	6N3S	6N3S
complex with mmts inhibitor	1.19 Å	6O2X	6O2X	6O2X	6O2X	6O2X	6O2X