PDBsum entry 1ewp

Hydrolase/hydrolase inhibitor

PDB id: 1ewp

Contents

Protein chain

215 a.a. *

Ligands

0I5

Waters ×67

* Residue conservation analysis

PDB id:

1ewp

Name:

Hydrolase/hydrolase inhibitor

Title:

Cruzain bound to mor-leu-hpq

Structure:

Cruzain. Chain: a. Fragment: catalytic domain. Synonym: cruzipain, cruzaine. Engineered: yes

Source:

Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.75Å R-factor: 0.183 R-free: 0.206

Authors:

S.A.Gillmor

Key ref:

S.A.Gillmor (1998). Chapter 3: X-Ray structures of complexes of cruzain with designed covalent inhibitors. Enzyme-Ligand interactions, Inhibition and specificity, 50-80.

Date:

26-Apr-00 Release date: 17-May-00

Protein chain

P25779  (CYSP_TRYCR) -  Cruzipain from Trypanosoma cruzi

Seq: 467 a.a.

Struc: 215 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.22.51 - cruzipain.