PDBsum entry 3lxs

Hydrolase

PDB id: 3lxs

Contents

Protein chains

215 a.a. *

Ligands

4MC ×2

EDO ×17

SO4 ×7

Waters ×485

* Residue conservation analysis

PDB id:

3lxs

Name:

Hydrolase

Title:

Crystal structure analysis of cruzain bound to vinyl sulfone derived inhibitor (wrr483)

Structure:

Cruzain. Chain: a, c. Fragment: cruzain mature domain. Synonym: cruzipain, cruzaine, major cysteine proteinase. Engineered: yes

Source:

Trypanosoma cruzi. Organism_taxid: 5693. Gene: cruzipain. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.50Å R-factor: 0.124 R-free: 0.158

Authors:

I.D.Kerr,L.S.Brinen

Key ref:

Y.T.Chen et al. (2010). In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. Plos Negl Trop Dis, 4, . PubMed id: 20856868

Date:

25-Feb-10 Release date: 20-Oct-10

Supersedes:

2efm

Protein chains

P25779  (CYSP_TRYCR) -  Cruzipain from Trypanosoma cruzi

Seq: 467 a.a.

Struc: 215 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.22.51 - cruzipain.

Plos Negl Trop Dis 4: (2010)

PubMed id: 20856868

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

Y.T.Chen, L.S.Brinen, I.D.Kerr, E.Hansell, P.S.Doyle, J.H.McKerrow, W.R.Roush.

ABSTRACT

No abstract given.