PDBsum entry 2efm

Hydrolase

PDB id: 2efm

Contents

Protein chains

215 a.a. *

Ligands

4MC ×2

EDO ×27

SO4 ×10

Waters ×519

* Residue conservation analysis

Superseded by:

3lxs

PDB id:

2efm

Name:

Hydrolase

Title:

Crystal structure analysis of cruzain bound to vinyl sulfone derived inhibitor (wr483)

Structure:

Cruzipain. Chain: a, c. Fragment: catalytic domain. Synonym: cruzipain, cruzaine, major cysteine proteinase. Engineered: yes

Source:

Trypanosoma cruzi. Organism_taxid: 5693. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Resolution:

1.50Å R-factor: 0.145 R-free: 0.187

Authors:

M.Rickert,L.Brinen

Key ref:

M.Rickert and l.brinen The high resolution structure of rhodesain, The major cathepsin l from t. Brucei rhodesiense, Illustrates the basis for differences in inhibition profiles from other papain family cysteine proteases. To be published, .

Date:

23-Feb-07 Release date: 26-Feb-08

Protein chains

P25779  (CYSP_TRYCR) -  Cruzipain from Trypanosoma cruzi

Seq: 467 a.a.

Struc: 215 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.22.51 - cruzipain.