Structure for peptidase C01.001: papain

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1PE6	Carica papaya	2.10 Å	complex with E64C
Catalytic residues are shown in ball-and-stick representation: Cys158 in yellow, His292 in purple and Asn308 in pink. E-64 is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Carica papaya
complex with carbobenzyloxy-Leu-leucinal inhibitor	2.20 Å	1BP4	1BP4	1BP4	1BP4	1BP4	1BP4	LaLonde et al., 1998
complex with carboxybenzyloxy-Leu-Leu-methoxymethylketone	2.50 Å	1BQI	1BQI	1BQI	1BQI	1BQI	1BQI	LaLonde et al., 1998
complex with inhibitor CLIK148	1.70 Å	1CVZ	1CVZ	1CVZ	1CVZ	1CVZ	1CVZ	Tsuge et al., 1999
theoretical model; complex with N-acetyl-p-benzoquinone imine	0.00 Å	1EFF	1EFF	1EFF	1EFF	1EFF	1EFF
complex with Z-Leu-Phe-Gly-diazomethylketone inhibitor	2.00 Å	1KHP	1KHP	1KHP	1KHP	1KHP	1KHP	Janowski et al., 2004
complex with Z-Leu-Phe-Gly-diazomethylketone inhibitor (orthorhombic form)	1.60 Å	1KHQ	1KHQ	1KHQ	1KHQ	1KHQ	1KHQ	Janowski et al., 2004
Cys25Ac-Ala-Ala-Phe-methylenylAla derivative	2.80 Å	1PAD	1PAD	1PAD	1PAD	1PAD	1PAD	Drenth et al., 1976
complex with E64C	2.10 Å	1PE6	1PE6	1PE6	1PE6	1PE6	1PE6	Yamamoto et al., 1991
complex with Suc-Gln-Vla-Val-Ala-Ala-pNA	1.70 Å	1PIP	1PIP	1PIP	1PIP	1PIP	1PIP	Yamamoto et al., 1992
complex with leupeptin	2.10 Å	1POP	1POP	1POP	1POP	1POP	1POP	Schroder et al., 1993
hydroxyethylthiopapain	2.00 Å	1PPD	1PPD	1PPD	1PPD	1PPD	1PPD
Cys25 with bound atom	1.60 Å	1PPN	1PPN	1PPN	1PPN	1PPN	1PPN
complex with E64C	1.90 Å	1PPP	1PPP	1PPP	1PPP	1PPP	1PPP	Kim et al., 1992
complex with cystatin B Cys18Ser	2.37 Å	1STF	1STF	1STF	1STF	1STF	1STF	Stubbs et al., 1990
complex with ICP	1.50 Å	2CIO	2CIO	2CIO	2CIO	2CIO	2CIO	Alphey & Hunter, 2006
cysteinyl derivative of Cys25	2.80 Å	2PAD	2PAD	2PAD	2PAD	2PAD	2PAD	Drenth et al., 1976
complex with chagasin	1.86 Å	3E1Z	3E1Z	3E1Z	3E1Z	3E1Z	3E1Z	Redzynia et al., 2009
complex with tarocystatin	2.03 Å	3IMA	3IMA	3IMA	3IMA	3IMA	3IMA
complex with CTD of tarocystatin	2.60 Å	3LFY	3LFY	3LFY	3LFY	3LFY	3LFY
precursor; thermostable variant	2.62 Å	3TNX	3TNX	3TNX	3TNX	3TNX	3TNX
precursor; thermostable variant from a crystal soaked at ph 4	3.80 Å	3USV	3USV	3USV	3USV	3USV	3USV
TOS-methylenylLys derivative of Cys25	2.80 Å	4PAD	4PAD	4PAD	4PAD	4PAD	4PAD	Drenth et al., 1976
Ile86Leu mutant	2.50 Å	4QRG	4QRG	4QRG	4QRG	4QRG	4QRG
Ile86Phe mutant	1.98 Å	4QRV	4QRV	4QRV	4QRV	4QRV	4QRV
precursor mutant at ph 4.0	3.14 Å	4QRX	4QRX	4QRX	4QRX	4QRX	4QRX
benzyloxycarbonyl-Gly-Phe-methylenylGly derivative	2.80 Å	5PAD	5PAD	5PAD	5PAD	5PAD	5PAD	Drenth et al., 1976
modified by achiral ru(ii)complex	2.10 Å	6H8T	6H8T	6H8T	6H8T	6H8T	6H8T
benzyloxycarbonyl-Gly-Phe-methylenylGly derivative	2.80 Å	6PAD	6PAD	6PAD	6PAD	6PAD	6PAD	Drenth et al., 1976
Cys25 oxidized	1.65 Å	9PAP	9PAP	9PAP	9PAP	9PAP	9PAP	Kamphuis et al., 1984