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Literature for peptidase C01.001: papain

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, P Specificity, I Inhibitor, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Ansari,M., Prajapati,K.P., Mittal,S., Mishra,S., Gupta,V., Anand,B.G. and Kar,K.
    High-low temperature switch induces formation of catalytic and cytotoxic amyloid aggregates of papain
    Food Chem479, 143657-143657. PubMed  Europe PubMed DOI
  2. Choudhary,R., Kaushik,R., Chawla,P. and Manna,S.
    Exploring the extraction, functional properties, and industrial applications of papain from Carica papaya
    J Sci Food Agric105, 1533-1545. PubMed  Europe PubMed DOI  V
    3. 2024
  3. Glahn,J.Z., Wang-Evers,M., Carlson,A.R., Marks,H., Karasik,D., Hilge,F., Goverman,J. and Manstein,D.
    Evaluation of Papain-Urea for Enzymatic Debridement of Coagulation Zones Following Ablative Fractional Laser Treatment
    Lasers Surg Med PubMed  Europe PubMed DOI
    4. 2023
  4. Liu,X., Huang,Q., Pan,P., Fang,M., Zhang,Y., Yang,S., Li,M. and Liu,Y.
    Comparative Study of the Preparation of High-Molecular-Weight Fibroin by Degumming Silk with Several Neutral Proteases
    Polymers (Basel)15, PubMed  Europe PubMed DOI
    5. 2022
  5. Bruce,B.
    Enzyme treatment of red blood cells: use of ficin and papain
    Immunohematology38, 90-95. PubMed  Europe PubMed DOI  V
    6. 2021
  6. Annahazi,A., Schroder,A. and Schemann,M.
    Region-specific effects of the cysteine protease papain on gastric motility
    Neurogastroenterol Motile14105-e14105. PubMed  Europe PubMed DOI
  7. Baidamshina,D.R., Koroleva,V.A., Olshannikova,S.S., Trizna,E.Y., Bogachev,M.I., Artyukhov,V.G., Holyavka,M.G. and Kayumov,A.R.
    Biochemical Properties and Anti-Biofilm Activity of Chitosan-Immobilized Papain
    Mar Drugs19, PubMed  Europe PubMed DOI
  8. Kunimine,S., Takai,T., Kamijo,S., Maruyama,N., Kimitsu,T., Masutani,Y., Yoshimura,T., Suchiva,P., Shimizu,S., Ogawa,H., Okumura,K. and Ikeda,S.
    Epicutaneous vaccination with protease inhibitor-treated papain prevents papain-induced Th2-mediated airway inflammation without inducing Th17 in mice
    Biochem Biophys Res Commun546, 192-199. PubMed  Europe PubMed DOI
    9. 2020
  9. Azarkan,M., Maquoi,E., Delbrassine,F., Herman,R., M'rabet,N., Calvo Esposito,R., Charlier,P. and Kerff,F.
    Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity
    Sci Rep10, 19570-19570. PubMed  Europe PubMed DOI  I
  10. Feng,N., Zhang,H., Li,Y., Liu,Y., Xu,L., Wang,Y., Fei,X. and Tian,J.
    A novel catalytic material for hydrolyzing cow's milk allergenic proteins: papain-Cu3(PO4)2.3H2O-magnetic nanoflowers
    Food Chem311, 125911-125911. PubMed  Europe PubMed DOI
  11. Filippova,I.Y., Dvoryakova,E.A., Sokolenko,N.I., Simonyan,T.R., Tereshchenkova,V.F., Zhiganov,N.I., Dunaevsky,Y.E., Belozersky,M.A., Oppert,B. and Elpidina,E.N.
    New Glutamine-Containing Substrates for the Assay of Cysteine Peptidases From the C1 Papain Family
    Front Mol Biosci7, 578758-578758. PubMed  Europe PubMed DOI
  12. Fukuda,K., Matsuzaki,H., Mikami,Y., Makita,K., Miyakawa,K., Miyashita,N., Hosoki,K., Ishii,T., Noguchi,S., Urushiyama,H., Horie,M., Mitani,A., Yamauchi,Y., Shimura,E., Nakae,S., Saito,A., Nagase,T. and Hiraishi,Y.
    A mouse model of asthma-chronic obstructive pulmonary disease overlap induced by intratracheal papain
    Allergy PubMed  Europe PubMed DOI
  13. Hafid,K., John,J., Sayah,T.M., Dominguez,R., Becila,S., Lamri,M., Dib,A.L., Lorenzo,J.M. and Gagaoua,M.
    One-step recovery of latex papain from Carica papaya using Three Phase Partitioning and its use as milk-clotting and meat-tenderizing agent
    Int J Biol Macromol146, 798-810. PubMed  Europe PubMed DOI
  14. Jastaniah,A., Gaisina,I.N., Knopp,R.C. and Thatcher,G.R.J.
    Synthesis of alpha-Ketoamide-Based Stereoselective Calpain-1 Inhibitors as Neuroprotective Agents
    ChemMedChem PubMed  Europe PubMed DOI  I
  15. Lima,A.M., Barros,N.L.F., Freitas,A.C.O., Tavares,L.S.C., Pirovani,C.P., Siqueira,A.S., Goncalves,E.C. and de Souza,C.R.B.
    A new Piper nigrum cysteine proteinase inhibitor, PnCPI, with antifungal activity: molecular cloning, recombinant expression, functional analyses and molecular modeling
    Planta252, 16-16. PubMed  Europe PubMed DOI
  16. Lin,K.P., Feng,G.J., Pu,F.L., Hou,X.D. and Cao,S.L.
    Enhancing the Thermostability of Papain by Immobilizing on Deep Eutectic Solvents-Treated Chitosan With Optimal Microporous Structure and Catalytic Microenvironment
    Front Bioeng Biotechnol8, 576266-576266. PubMed  Europe PubMed DOI
  17. Meenu,S., Pradeep,B., Ramalingam,S., Sairam,T., Rai,R. and Sankaran,R.
    Papillon-Lefevre syndrome (PLS) with novel compound heterozygous mutation in the exclusion and Peptidase C1A domains of Cathepsin C gene
    Mol Biol Rep PubMed  Europe PubMed DOI
  18. Mishra,M., Singh,V., Tellis,M.B., Joshi,R.S. and Singh,S.
    Repurposing the McoTI-II Rigid Molecular Scaffold in to Inhibitor of 'Papain Superfamily' Cysteine Proteases
    Pharmaceuticals (Basel)14, PubMed  Europe PubMed DOI
  19. Moreira Filho,R.N.F., Vasconcelos,N.F., Andrade,F.K., Rosa,M.F. and Vieira,R.S.
    Papain immobilized on alginate membrane for wound dressing application
    Colloids Surf B Biointerfaces194, 111222-111222. PubMed  Europe PubMed DOI
  20. Shinu,P., Singh,V.A., Nair,A., Venugopala,K.N. and Akrawi,S.H.
    Papain-cetylpyridinium chloride and pepsin-cetylpyridinium chloride; two novel, highly sensitive, concentration, digestion and decontamination techniques for culturing mycobacteria from clinically suspected pulmonary tuberculosis cases
    PLoS ONE15, e0236700-e0236700. PubMed  Europe PubMed DOI
  21. Soares,A.M.B.F., Goncalves,L.M.O., Ferreira,R.D.S., de Souza,J.M., Fangueiro,R., Alves,M.M.M., Carvalho,F.A.A., Mendes,A.N. and Cantanhede,W.
    Immobilization of papain enzyme on a hybrid support containing zinc oxide nanoparticles and chitosan for clinical applications
    Carbohydr Polym243, 116498-116498. PubMed  Europe PubMed DOI
  22. Wang,X., Gao,Y., Guan,Z., Xie,Z., Zhang,D., Yin,P., Yang,G., Hong,D. and Xin,Q.
    Structural analysis of the meiosis-related protein MS5 reveals non-canonical papain enhancement by cystatin-like folds
    FEBS Lett594, 2462-2471. PubMed  Europe PubMed DOI  S
    23. 2019
  23. Gimenez-Dejoz,J., Tsuchiya,K. and Numata,K.
    Insights into the stereospecificity in papain-mediated chemoenzymatic polymerization from quantum mechanics/molecular mechanics simulations
    ACS Chem Biol14, 1280-1292. PubMed  Europe PubMed DOI
  24. Liu,C., Barrett,T.M., Chen,X., Ferrie,J.J. and Petersson,E.J.
    Fluorescent probes for studying thioamide positional effects on proteolysis reveal insight into resistance to cysteine proteases
    Chembiochem20, 2059-2062. PubMed  Europe PubMed DOI  I
  25. Milosevic,J., Jankovic,B., Prodanovic,R. and Polovic,N.
    Comparative stability of ficin and papain in acidic conditions and the presence of ethanol
    Amino Acids51, 829-838. PubMed  Europe PubMed DOI
  26. Mohan,V., Das,N., Das,A., Mishra,V. and Sen,P.
    Spectroscopic insight on ethanol-induced aggregation of papain
    J Phys Chem B123, 2280-2290. PubMed  Europe PubMed DOI
  27. Sang,M., Xu,C., Wei,Z., Wu,X., Guo,Y., Li,J., Wang,Z. and Zhang,J.
    Cloning and high-level SUMO-mediated fusion expression of a serine protease inhibitor from Hyphantria cunea Drury that exhibits activity against papain
    Protein Expr Purif158, 36-43. PubMed  Europe PubMed DOI
  28. Santis,L.P., Garcia,P.C., Secco,V.N.D.P., Ferreira,R.R. and Deffune,E.
    Applicability of papain solutions in immunohematology
    Einstein (Sao Paulo)17, eAO4328-eAO4328. PubMed  Europe PubMed DOI
  29. Yu,L., Zhang,H., Yang,L. and Tian,K.
    Optimization of purification conditions for papain in a polyethylene glycol-phosphate aqueous two-phase system using quaternary ammonium ionic liquids as adjuvants by BBD-RSM
    Protein Expr Purif156, 8-16. PubMed  Europe PubMed DOI
    30. 2018
  30. Gu,X., Gao,J., Li,X. and Wang,Y.
    Immobilization of papain onto graphene oxide nanosheets
    J Nanosci Nanotechnol18, 3543-3547. PubMed  Europe PubMed DOI
  31. Gu,Y.J., Zhu,M.L., Li,Y.L. and Xiong,C.H.
    Research of a new metal chelating carrier preparation and papain immobilization
    Int J Biol Macromol112, 1175-1182. PubMed  Europe PubMed DOI
    32. 2017
  32. Lin,M., Yu,T., Wan,J. and Cao,X.
    Prediction of the reverse micellar extraction of papain using dissipative particle dynamics simulation
    Appl Biochem Biotechnol181, 1338-1346. PubMed  Europe PubMed DOI
  33. Moraes,D., Levenhagen,M.A., Costa-Cruz,J.M., daCosta-Netto,A.P. and Rodrigues,R.M.
    In vitro efficacy of latex and purified papain from Carica papaya against Strongyloides venezuelensis eggs and larvae
    Rev Inst Med Trop Sao Paulo59, DOI
  34. Moraes,D., Levenhagen,M.A., Costa-Cruz,J.M., Costa AP Netto and Rodrigues,R.M.
    In vitro efficacy of latex and purified papain from Carica papaya against Strongyloides venezuelensis eggs and larvae
    Rev Inst Med Trop Sao Paulo59, e7-e7. PubMed  Europe PubMed DOI
  35. Mugita,N., Nambu,T., Takahashi,K., Wang,P.L. and Komasa,Y.
    Proteases, actinidin, papain and trypsin reduce oral biofilm on the tongue in elderly subjects and in vitro
    Arch Oral Biol82, 233-240. PubMed  Europe PubMed DOI  U
  36. Prabhu A,A., Chityala,S., Garg,Y. and Venkata Dasu,V.
    Reverse micellar extraction of papain with cationic detergent based system: an optimization approach
    Prep Biochem Biotechnol47, 236-244. PubMed  Europe PubMed DOI
    37. 2016
  37. Dutta,S., Choudhury,D., Roy,S., Dattagupta,J.K. and Biswas,S.
    Mutation in the pro-peptide region of a cysteine protease leads to altered activity and specificity - a structural and biochemical approach
    PLoS ONE11, e0158024-e0158024. PubMed  Europe PubMed DOI
  38. Fekete,A. and Komaromi,I.
    Modeling the archetype cysteine protease reaction using dispersion corrected density functional methods in ONIOM-type hybrid QM/MM calculations; the proteolytic reaction of papain
    Phys Chem Chem Phys18, 32847-32861. PubMed  Europe PubMed DOI
  39. Li,Q., Zhou,Y., Ma,K., Wei,Q. and Nie,Z.
    A mesoporous SiO2/dense SiO2/Fe3O4 multiply coated hollow microsphere: synthesis and application on papain immobilization
    Colloids Surf A Physicochem Eng Asp511, 239-246. DOI
  40. Maria Manohar,C. and Doble,M.
    Papain immobilized polyurethane as an ureteral stent material
    J Biomed Mater Res B Appl Biomater104, 723-731. PubMed  Europe PubMed DOI
  41. Muller,A., Barat,S., Chen,X., Bui,K.C., Bozko,P., Malek,N.P. and Plentz,R.R.
    Comparative study of antitumor effects of bromelain and papain in human cholangiocarcinoma cell lines
    Int J Oncol48, 2025-2034. PubMed  Europe PubMed DOI  U
  42. Rocha,M.V., DiGiacomo,M., Beltramino,S., Loh,W., Romanini,D. and Nerli,B.B.
    A sustainable affinity partitioning process to recover papain from Carica papaya latex using alginate as macro-ligand
    Sep Purif Technol168, 168-176. DOI
  43. Tsuchiya,K. and Numata,K.
    Papain-catalyzed chemoenzymatic synthesis of telechelic polypeptides using bis(leucine ethyl ester) initiator
    Macromol Biosci16, 1001-1008. PubMed  Europe PubMed DOI
  44. Yu,J., Lin,F., Lin,S., Pei,X., Miao,J., Chen,X., Wu,S.G. and Wang,A.
    A comparative study of papain and bromelain in enzymatic oligomerization of l-Phe methyl ester in aqueous environment
    J Mol Catal B Enzym133, S95-S99. DOI
    45. 2015
  45. Benucci,I., Esti,M. and Liburdi,K.
    Effect of wine inhibitors on the proteolytic activity of papain from Carica papaya L. latex
    Biotechnol Prog31, 48-54. PubMed  Europe PubMed DOI  I
  46. Homaei,A.
    Enhanced activity and stability of papain immobilized on CNBr-activated sepharose
    Int J Biol Macromol75, 373-377. PubMed  Europe PubMed DOI
  47. Jiang,Z.G., Zhang,H.D. and Wang,W.T.
    Purification of papain by metal affinity partitioning in aqueous two-phase polyethylene glycol/sodium sulfate systems
    J Sep Sci38, 1426-1432. PubMed  Europe PubMed DOI
  48. Junior,Z.S., Botta,S.B., Ana,P.A., Franca,C.M., Fernandes,K.P., Mesquita-Ferrari,R.A., Deana,A. and Bussadori,S.K.
    Effect of papain-based gel on type I collagen - spectroscopy applied for microstructural analysis
    Sci Rep5, 11448-11448. PubMed  Europe PubMed DOI  U
  49. Mera,T. and Faustman,D.L.
    Removal of donor human leukocyte antigen class I proteins with papain: translation for possible whole organ practices
    Transplantation99, 724-730. PubMed  Europe PubMed DOI
  50. Mitsuhashi,J., Nakayama,T. and Narai-Kanayama,A.
    Mechanism of papain-catalyzed synthesis of oligo-tyrosine peptides
    Enzyme Microb Technol75-76, 10-17. PubMed  Europe PubMed DOI
  51. Nishikado,H., Fujimura,T., Taka,H., Mineki,R., Ogawa,H., Okumura,K. and Takai,T.
    Cysteine protease antigens cleave CD123, the alpha subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion
    Biochem Biophys Res Commun460, 261-266. PubMed  Europe PubMed DOI
  52. Raskovic,B., Popovic,M., Ostojic,S., Andelkovic,B., Tesevic,V. and Polovic,N.
    Fourier transform infrared spectroscopy provides an evidence of papain denaturation and aggregation during cold storage
    Spectrochim Acta A Mol Biomol Spectrosc150, 238-246. PubMed  Europe PubMed DOI
  53. Ribeiro,A.P., Oliveira,B.G., Soares,M.F., Barreto,B.M., Futuro,D.O. and Castilho,S.R.
    [Effectiveness of 2% and 4% papain gels in the healing of venous ulcers]
    Rev Esc Enferm USP49, 394-402. PubMed  Europe PubMed DOI  U
  54. Rodrigues,A.L., Oliveira,B.G., Futuro,D.O. and Secoli,S.R.
    Effectiveness of papain gel in venous ulcer treatment: randomized clinical trial
    Rev Lat Am Enfermagem23, 458-465. PubMed  Europe PubMed DOI  U
  55. Wang,W., Jiang,Z., Zhang,H., Peng,J., Xu,Y., Dong,A., Yang,X. and Jiang,X.
    Partitioning behavior and structural characterization of papain in ionic liquid aqueous two-phase system
    Huagong Xuebao66, 179-185. DOI
    56. 2014
  56. Dong,A.-H., Peng,J., Xu,Y.-H., Wang,W.-T., Jiang,X.-X. and Zhang,H.-D.
    Correlation of PEG/(NH4)2SO4 aqueous two-phase equilibrium data and modeling of partition of papain
    Mod Food Sci Technol30, 194-199. DOI
  57. Doolittle,R.F.
    Clotting of mammalian fibrinogens by papain: a re-examination
    Biochemistry53, 6687-6694. PubMed  Europe PubMed DOI
  58. Kathman,S.G., Xu,Z. and Statsyuk,A.V.
    A fragment-based method to discover irreversible covalent inhibitors of cysteine proteases
    J Med Chem57, 4969-4974. PubMed  Europe PubMed DOI  I
  59. Le,Z.G., Ni,K., Guo,L.T. and Xie,Z.B.
    The condensation reaction of 4-nitrobenzaldehyde and rhodanine catalyzed by papain
    Adv Mater Res830, 111-114. DOI
  60. Miyazawa,T., Horimoto,T. and Tanaka,K.
    Kinetically controlled peptide synthesis mediated by papain using the carbamoylmethyl ester as an acyl donor
    Int J Pept Res Ther20, 371-376. DOI
  61. Muller,C., Perera,G., Konig,V. and Bernkop-Schnurch,A.
    Development and in vivo evaluation of papain-functionalized nanoparticles
    Eur J Pharm Biopharm87, 125-131. PubMed  Europe PubMed DOI  U
  62. Rosenstein,R.K., Bezbradica,J.S., Yu,S. and Medzhitov,R.
    Signaling pathways activated by a protease allergen in basophils
    Proc Natl Acad Sci U S A111, E4963-E4971. PubMed  Europe PubMed DOI
  63. Wammes,A.E., Hendriks,T.G., Amatdjais-Groenen,H.I., Wijdeven,M.A., van Hest,J.C., van Delft,F.L., Ritschel,T. and Rutjes,F.P.
    Influence of azide incorporation on binding affinity by small papain inhibitors
    Bioorg Med Chem22, 5593-5603. PubMed  Europe PubMed DOI  I
  64. Wang,W.-T., Zhang,H.-D., Jiang,Z.-G., Xu,Y.-H., Dong,A.-H., Peng,J. and Yang,X.-F.
    Extraction of papain by ionic liquid/aqueous two-phase system and optimization of process conditions
    Mod Food Sci Technol30, 210-216. DOI
    65. 2013
  65. Braia,M., Ferrero,M., Rocha,M.V., Loureiro,D., Tubio,G. and Romanini,D.
    Bioseparation of papain from Carica papaya latex by precipitation of papain-poly (vinyl sulfonate) complexes
    Protein Expr Purif91, 91-95. PubMed  Europe PubMed DOI
  66. Esti,M., Benucci,I., Lombardelli,C., Liburdi,K. and Garzillo,A.M.V.
    Papain from papaya (Carica papaya L.) fruit and latex: preliminary characterization in alcoholic-acidic buffer for wine application
    Food Bioprod Process91, 595-598. DOI
  67. Kamijo,S., Takeda,H., Tokura,T., Suzuki,M., Inui,K., Hara,M., Matsuda,H., Matsuda,A., Oboki,K., Ohno,T., Saito,H., Nakae,S., Sudo,K., Suto,H., Ichikawa,S., Ogawa,H., Okumura,K. and Takai,T.
    IL-33-Mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation
    J Immunol190, 4489-4499. PubMed  Europe PubMed DOI
  68. Rathnasamy,S. and Kumaresan,R.
    Design and development of single stage purification of papain using ionic liquid based aqueous two phase extraction system and its partition coefficient studies
    Intern J Eng Technol5, 1934-1941.
  69. Rocha,M.V. and Nerli,B.B.
    Molecular features determining different partitioning patterns of papain and bromelain in aqueous two-phase systems
    Int J Biol Macromol61, 204-211. PubMed  Europe PubMed DOI
  70. Wei,D., Huang,X., Liu,J., Tang,M. and Zhan,C.G.
    Reaction pathway and free energy profile for papain-catalyzed hydrolysis of N-acetyl-Phe-Gly 4-nitroanilide
    Biochemistry52, 5145-5154. PubMed  Europe PubMed DOI
    71. 2012
  71. Bhardwaj,A. and Bhardwaj,S.V.
    Papacarie(R) containing papain: a natural chemomechanical caries removal agent
    Res J Pharm Biol Chem Sci3, 660-666.  U
  72. Campbell,R.L. and Davies,P.L.
    Structure-function relationships in calpains
    Biochem J447, 335-351. PubMed  Europe PubMed DOI  V
  73. Chen,J.S., Tian,J.C., Deng,Z.Y., Zhang,Y.X., Feng,S.L., Yan,Z.C., Zhang,X.Y. and Yuan,H.Q.
    Effects of papain hydrolysis on the pasting properties of wheat flour
    J Integr Agric11, 1948-1957. DOI
  74. Hu,W., Guan,Z., Deng,X. and He,Y.H.
    Enzyme catalytic promiscuity: the papain-catalyzed Knoevenagel reaction
    Biochimie94, 656-661. PubMed  Europe PubMed DOI
  75. Kim,C.J., Lee,D.I., Lee,C.H. and Ahn,I.S.
    A dityrosine-based substrate for a protease assay: application for the selective assessment of papain and chymopapain activity
    Anal Chim Acta723, 101-107. PubMed  Europe PubMed DOI  A
  76. Leite,A.P., de Oliveira,B.G., Soares,M.F. and Barrocas,D.L.
    [Use and effectiveness of papain in the wound healing process: a systematic review]
    Rev Gaucha Enferm33, 198-207. PubMed  Europe PubMed  U
  77. Llerena-Suster,C.R., Jose,C., Collins,S.E., Briand,L.E. and Morcelle,S.R.
    Investigation of the structure and proteolytic activity of papain in aqueous miscible organic media
    Process Biochem47, 47-56. DOI
  78. Nishiyama,K.
    Local fluctuation control of papain by changing a highly fluctuating residue
    Chem Phys Lett555, 226-229. DOI
  79. Pithon,M.M., de Souza Ferraz,C., do Couto de Oliveira,G., Pereira,T.B., Oliveira,D.D., de Souza,R.A., de Freitas,L.M. and Dos Santos,R.L.
    Effect of 10% papain gel on enamel deproteinization before bonding procedure
    Angle Orthod82, 541-545. PubMed  Europe PubMed DOI  U
  80. Roy,S., Choudhury,D., Aich,P., Dattagupta,J.K. and Biswas,S.
    The structure of a thermostable mutant of pro-papain reveals its activation mechanism
    Acta Crystallogr D Biol Crystallogr68, 1591-1603. PubMed  Europe PubMed DOI
  81. Storer,A.C. and Menard,R.
    Papain
    [ISSN:978-0-12-407743-0]3, 1858-1861. DOI
    82. 2011
  82. de Beer,R.J., Zarzycka,B., Amatdjais-Groenen,H.I., Jans,S.C., Nuijens,T., Quaedflieg,P.J., van Delft,F.L., Nabuurs,S.B. and Rutjes,F.P.
    Papain-catalyzed peptide bond formation: enzyme-specific activation with guanidinophenyl esters
    Chembiochem12, 2201-2207. PubMed  Europe PubMed DOI
  83. Fosado-Quiroz,R.E. and Rojo-Dominguez,A.
    Metastability of papain and the molecular mechanism for its sequential acid-denaturation
    Protein J30, 184-193. PubMed  Europe PubMed DOI
  84. Hussain,S., Khan,A., Gul,S., Resmini,M., Verma,C.S., Thomas,E.W. and Brocklehurst,K.
    Identification of interactions involved in the generation of nucleophilic reactivity and of catalytic competence in the catalytic site Cys/His ion pair of papain
    Biochemistry50, 10732-10742. PubMed  Europe PubMed DOI
  85. Llerena-Suster,C.R., Priolo,N.S. and Morcelle,S.R.
    Sodium tetrathionate effect on papain purification from different Carica papaya latex crude extracts
    Prep Biochem Biotechnol41, 107-121. PubMed  Europe PubMed DOI
  86. Nishiyama,K.
    Substrate specificity of papain dynamic structures for peptides consisting of 8-10 Gly residues
    Chem Phys Lett501, 513-516. DOI  I
  87. Shokhen,M., Khazanov,N. and Albeck,A.
    The mechanism of papain inhibition by peptidyl aldehydes
    Proteins79, 975-985. PubMed  Europe PubMed DOI  I
  88. Wang,G., Xi,H., Tian,F., Han,M. and Lu,Y.
    Mechanism of molecular interaction between ethionamide and papain: spectroscopic and molecular simulation investigations
    Acta Chim Sin69, 95-100.
  89. Wang,M., Qi,W., Yu,Q., Su,R. and He,Z.
    Kinetically controlled enzymatic synthesis of dipeptide precursor of l-alanyl-l-glutamine
    Biotechnol Appl Biochem58, 449-455. PubMed  Europe PubMed DOI
    90. 2010
  90. Ajlia,S.A.S.H., Majid,F.A.A., Suvik,A., Effendy,M.A.W. and Serati Nouri,H.
    Efficacy of papain-based wound cleanser in promoting wound regeneration
    Pak J Biol Sci13, 596-603. PubMed  Europe PubMed  U
  91. Choudhury,D., Biswas,S., Roy,S. and Dattagupta,J.K.
    Improving thermostability of papain through structure-based protein engineering
    Protein Eng Des Sel23, 457-467. PubMed  Europe PubMed DOI  E
  92. da Silva,C.R., Oliveira,M.B., Motta,E.S., de Almeida,G.S., Varanda,L.L., de Padula,M., Leitao,A.C. and Caldeira-de-Araujo,A.
    Genotoxic and cytotoxic safety evaluation of papain (Carica papaya L.) using in vitro assays
    J Biomed Biotechnol2010, 197898-197898. PubMed  Europe PubMed DOI  U
  93. Jeong,J. and Hur,W.
    Even-numbered peptides from a papain hydrolysate of silk fibroin
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