PDBsum entry 1ppd

Hydrolase (sulfhydryl proteinase)

PDB id: 1ppd

Contents

Protein chain

212 a.a. *

Ligands

BME

Waters ×211

* Residue conservation analysis

PDB id:

1ppd

Name:

Hydrolase (sulfhydryl proteinase)

Title:

Restrained least-squares refinement of the sulfhydryl protease papain to 2.0 angstroms

Structure:

2-hydroxyethyl-thiopapain. Chain: a. Engineered: yes

Source:

Carica papaya. Papaya. Organism_taxid: 3649

Resolution:

2.00Å R-factor: 0.145

Authors:

J.N.Jansonius

Key ref:

J.P.Priestle et al. (1984). Restrained least-Squares refinement of the sulfhydryl protease papain to 2.0 angstroms. Acta crystallogr ,Sect a, 40, 17.

Date:

06-Nov-84 Release date: 02-Jan-85

Protein chain

P00784  (PAPA1_CARPA) -  Papain from Carica papaya

Seq: 345 a.a.

Struc: 212 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.22.2 - papain.
• Reaction: Hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic sidechain at the P2 position. Does not accept Val at P1'.