Substrates for peptidase S01.258: trypsin-2 type A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
collagen alpha-1(II) chain	P02458	182-1241	peptide-Arg818+Gly-peptide	P	MS	Ala	Gly	Ala	Arg	Gly	Ala	Pro	Gly	Stenman et al., 2005
collagen alpha-1(II) chain	P02458	182-1241	peptide-Arg904+Val-peptide	P	MS	Ala	Ala	Gly	Arg	Val	Gly	Pro	Pro	Stenman et al., 2005
collagen alpha-1(II) chain	P02458	182-1241	peptide-Arg1190+Gly-peptide	P	MS	Pro	Gly	Pro	Arg	Gly	Arg	Ser	Gly	Stenman et al., 2005
defensin-5	Q01523	20-94	peptide-Arg62+Ala-peptide	P	NT	Ser	Gln	Ala	Arg	Ala	Thr	Cys	Tyr	Weeks et al., 2006
defensin-5	Q01523	20-94	peptide-Arg68+Thr-peptide	P	NT	Cys	Tyr	Cys	Arg	Thr	Gly	Arg	Cys	Weeks et al., 2006
matrix metallopeptidase-2	P08253	30-660	peptide-Arg98+Lys-peptide	P		Glu	Thr	Met	Arg	Lys	Pro	Arg	Cys	Sorsa et al., 1997
matrix metallopeptidase-9	P14780	93-707	peptide-Arg106+Phe-peptide	P		Asp	Leu	Gly	Arg	Phe	Gln	Thr	Phe	Sorsa et al., 1997	3921
proteinase-activated receptor 2	P55086	26-399	peptide-Arg38+Ser-peptide	P	NT	Ser	Lys	Gly	Arg	Ser	Leu	Ile	Gly	Alm et al., 2000
Z-Gly-Pro-Arg-NHPhNO2			Z-Gly-Pro-Arg+NHPhNO2	S		Z	Gly	Pro	Arg	NAN	-	-	-	Chen & Ferec, 2004