Substrates for peptidase S01.156: enteropeptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
CLiPS synthetic peptide			peptide-Lys+Gly-peptide	S		Asp	Asp	Asp	Lys	Gly	Gly	Gln	Ser	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Met-peptide	S		Ser	Gly	Asp	Arg	Met	Trp	Gly	Gly	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Met-peptide	S		Ser	Gly	Glu	Arg	Met	Met	Gly	Gly	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Arg-peptide	S		Ser	Asp	Asp	Arg	Arg	Ala	Gly	Gly	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Met-peptide	S		Arg	Asp	Tyr	Arg	Met	Gly	Gly	Gln	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Ala-peptide	S		Ser	Ser	Asp	Arg	Ala	Arg	Val	Trp	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Phe-peptide	S		Val	Asp	Tyr	Arg	Phe	Leu	Gly	Ser	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Met-peptide	S		His	Gly	Glu	Arg	Met	Gly	Gly	Ser	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Met-peptide	S		Ser	Gly	Glu	Arg	Met	Gly	Gly	Ser	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Ala-peptide	S		Ser	Ser	Glu	Arg	Ala	Ala	Ala	Gly	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Trp-peptide	S		Val	Leu	Asp	Arg	Trp	Met	Gly	Gly	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Gln-peptide	S		Glu	Tyr	Asp	Arg	Gln	Leu	Gly	Ser	Boulware & Daugherty, 2006
CLiPS synthetic peptide			peptide-Arg+Trp-peptide	S		Ala	Val	Glu	Arg	Trp	Gly	Gly	Ser	Boulware & Daugherty, 2006
Gly-(Asp)4-Lys-NHNap			Gly-(Asp)4-Lys+NHNap	S		Asp	Asp	Asp	Lys	NAP	-	-	-	Sadler, 2004
Matrix metalloproteinase-9	P14780	20-707	peptide-Lys65+Ser-peptide	P	NT	Gly	Glu	Ser	Lys	Ser	Leu	Gly	Pro	Vilen et al., 2008
mesotrypsin	P35030	1-304	peptide-Lys80+Ile-peptide	P		Asp	Asp	Asp	Lys	Ile	Val	Gly	Gly	Knecht et al., 2007
potassium channel toxin alpha-KTx 8.2	Q9U8D2	1-57	peptide-Arg44+Ala-peptide	N		Gln	Asn	Ala	Arg	Ala	Lys	Cys	Asp	Chen et al., 2013
potassium channel toxin alpha-KTx 8.2	Q9U8D2	1-57	peptide-Lys51+Cys-peptide	N		Asp	Asn	Asp	Lys	Cys	Val	Cys	Glu	Chen et al., 2013
potassium channel toxin KTx1	P0DJL0	1-57	peptide-Arg41+Cys-peptide	N		Trp	Glu	Tyr	Arg	Cys	Leu	Ser	Ser	Chen et al., 2013
trypsin 1	P08426	16-247	peptide-Lys24+Ile-peptide	P		Asp	Asp	Asp	Lys	Ile	Val	Gly	Gly	Knecht et al., 2007
trypsinogen 1	P00760	18-246	Val-Asp-Asp-Asp-Asp-Lys6+Ile-peptide	P		Asp	Asp	Asp	Lys	Ile	Val	Gly	Gly	Sadler, 2004	17274