Substrates for peptidase S08.149: CDF peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
insulin	P01308	25-54	peptide-Phe48+Phe-peptide	N		Glu	Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Cheng et al., 2009
insulin	P01308	25-54	peptide-Leu35+Val-peptide	N		Gly	Ser	His	Leu	Val	Glu	Ala	Leu	Cheng et al., 2009
insulin	P01308	25-54	peptide-Leu39+Tyr-peptide	N		Val	Glu	Ala	Leu	Tyr	Leu	Val	Cys	Cheng et al., 2009
serine protease	A1E5M0	1-377	peptide-Thr85+Ile-peptide	P	NT	Ile	Arg	Ile	Thr	Ile	Thr	Glu	Pro	Cheng et al., 2009
serine protease	A1E5M0	86-377	peptide-Leu94+Asn-peptide	P	NT	Val	Gly	Thr	Leu	Asn	Thr	Pro	Val	Cheng et al., 2009