Cryo-EM structure of the human holo-TFIIH-XPC-XPA complex bound to bulky lesion-mimic DNA

Multi-body refinement component 3 of the cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA

Cryo-ET of endothelial cells cultured on electrospun gelatin fibers

TMV Map using Pulsed Illumination

Drosophila melanogaster insulin receptor ectodomain in complex with two DILP2 molecules

Drosophila melanogaster insulin receptor ectodomain in complex with one DILP2 molecule

TMV Map using Random (Conventional) Illumination

The intact LBD state of GluK2/K5 with 5-iodowillardiine and kynurenic acid sodium salt

CryoEM structure of the spike S protein trimer of the omicron BA.1 variant prepared in the presence of compound II-Na salt

Human vault protein - committed conformation

Yeast V1-ATPase bound to Rtc5p - Rtc5p (focused)

Yeast V1-ATPase bound to Rtc5p - V1 (focused)

Yeast V1-ATPase bound to Rtc5p, consensus map

The intact LBD state of GluK2/K5 with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)

Bacillus subtilis teneurin-like protein

Staphylococcal Enterotoxin C in complex with NB C107 and NB C112

CryoEM map of tetrameric non-photosynthetic NADP(+)-dependent malic enzyme

CryoEM map of chloroplastic photosynthetic NADP(+)-dependent malic enzyme mutant (G200R) at pH 8

CryoEM map of chloroplastic photosynthetic NADP(+)-dependent malic enzyme

CryoEM map of chloroplastic photosynthetic NADP(+)-dependent malic enzyme mutant (G200R) at pH 4.8

CryoEM map of dimeric non-photosynthetic NADP(+)-dependent malic enzyme

TMEM16F in liposomes in the presence of Ca2+ (closed state)

TMEM16F in liposomes in the absence of Ca2+ (expanded state)

TMEM16F D409G mutant in liposomes in the presence of Ca2+ (closed state)

TMEM16F D409G mutant in liposomes in the presence of Ca2+ (active state)

TMEM16F in liposomes in the presence of Ca2+ (active state)

TMEM16F R478E/E604R mutant in liposomes in the presence of Ca2+

Phosphonull (T175A) of stress-activating residues

A-beta42-Met-R-SO amyloidal fibril

Phosphonull (T175A) of stress-activating residues

HPV16 capsid bound to heparin

EcAvs2 bound to phage PhiV-1 terminase, overall C4 reconstruction

ZnO Nucleated Z4-C3i Trimer Within the Octahedral Z4-Cage Nanoparticle

Phosphonull (T209A) of stress-activating residues

Phosphonull (S56A) of stress-activating residues

Subparticle map of HPV16 hexavalent capsomer

Phosphomimetic (T209E) of stress-activating residues

EcAvs2 bound to phage PhiV-1 terminase, symmetry-expanded C1 refinement of TPR-terminase domain

Octahedral Z4-Cage Nanoparticle

Subparticle map of HPV16 pentavalent capsomer

Subparticle map of HPV16 hexavalent capsomer

Ca2+-bound GluN1a/2B NMDAR (S2)

Ca2+-bound GluN1a/2B NMDAR (S1)

Ca2+-bound GluN1a/2B NMDAR (S3)

Ca2+-bound GluN1a/2B NMDAR (S4)

Ca2+-bound GluN1a/2B NMDAR (S5)

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) (Bit61 focused)

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) in autoinhibited conformation (monomer Lst8 focused)

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) (Avo3 focused)

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) with Avo1 PH (Lst8 monomer focused)

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) (consensus refinement)

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) with the Avo1 PH domain (composite map)

Cryo-EM reconstruction of undecorated GDP microtubule

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) in autoinhibited conformation (composite map)

CryoEM structure of native quinol dependent Nitric Oxide Reductase at pH 6.5

CryoEM structure of native quinol dependent Nitric Oxide Reductase with HQE at pH 6.5

CryoEM structure of native quinol dependent Nitric Oxide Reductase Trp718Ala variant at pH 6.5 on gold grid.

CryoEM structure of native quinol dependent Nitric Oxide Reductase Arg720Ala variant at pH 6.5 on gold grid.

SKP1-FBXO22-UNC10088-NSD2 locally refined Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088

Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2, UNC10088 and Bach1

Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088

SKP1-FBXO22-UNC10088-NSD2 locally refined Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088 and Bach1

CUL1 C-term, RBX1 locally refined Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088

Consensus Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088

CUL1-C-terminus-RBX1 locally refined Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088 and Bach1

CUL1 locally refined Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088

SKP1-CUL1 locally refined Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088 and Bach1

Consensus Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088 and Bach1

CUL1 locally refined Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10415667

CUL1 C-term, RBX1 locally refined Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10415667

SKP1-FBXO22-UNC10088-NSD2 locally refined Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10415667

Consensus Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10415667

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) (Lst8-Avo1 CRIM focused)

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) with the Avo1 PH domain (monomer)

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) (monomer focused)

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) in autoinhibted conformation (monomer)

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) with the Avo1 PH domain

Cryo-EM reconstruction of undecorated GDP microtubule (13-3)

Cryo-EM reconstruction of the Kinesin KIF5A motor domain decorated GMPCPP microtubule (14-3)

CryoEM structure of native quinol dependent Nitric Oxide Reductase at pH 8.0 on gold grid.

Cryo-EM reconstruction of the Kinesin KIF5A motor domain decorated GMPCPP microtubule

CryoEM structure of native quinol dependent Nitric Oxide Reductase Trp718Ala variant with quino at pH 6.5 on gold grid.

Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10415667

Hexagonally Ordered Nanofibrils Easily Yield by dual Amphiphilic Self-Assembling Peptide

L. pneumophila 3-methylcrotonyl-CoA carboxylase holoenzyme A6B6

Haemophilus influenzae serotype b capsule polymerase bcs3 in complex with acceptor polymer

Assembly intermediate of human mitochondrial ribosome small subunit in complex with NOA1 and partial RBFA (state N2)

Membrane domain of Complex I from Ovis aries in presence of D1 inhibitor, Open state

Complex I from Ovis aries in presence of D1 inhibitor, Open state

Peripheral arm of Complex I from Ovis aries in presence of D1 inhibitor, Open state

Consensus map of Complex I Ovis aries in presence of D1 inhibitor, Open state

Haemophilus influenzae serotype b capsule polymerase bcs3

Complex I from Ovis aries in presence of D1 inhibitor, Closed state

The apo density map of BCL7B-containing ARP module of the human SWI/SNF complex

The ADP-bound density map of BCL7B-containing ARP module of the human SWI/SNF complex

STA of Capsid Protein from Gag VLPs derived from NL4.3 Plasmid

Cryo-electron microscopic structure of a novel amidohydrolase with three mutations

The structure of oocytes cytoplasmic lattice

the structure of oocytes cytoplasmic lattices-blob2

Cryo-EM structure and rational engineering of a novel efficient ochratoxin A-detoxifying amidohydrolase

The structure of oocytes cytoplasmic lattice-blob NLRP4f

the structure of oocytes cytoplasmic lattices-blob3

Cryo-electron microscopic structure of a highly efficient ochratoxin detoxification enzyme LlADH

the structure of oocytes cytoplasmic lattices-blob1

the structure of oocytes cytoplasmic lattices-consensus map

the structure of oocytes cytoplasmic lattices-blob1 tubulin

Herpes simplex virus 2 delta28-73 glycoprotein C ectodomain in complex with C3b

Nucleosome subtomogram average from chromatin droplets reconstituted with 25 bp linker DNA

CryoET of tailed phage from partially irrigated soil volume 1

CryoEM structure of Papaya Meleira Virus (PMeV) particles purified directly from Carica papaya latex

Cryo-ET of non-symmetric viruses from partially irrigated soils volume 1

CryoET of tailed phages from partially irrigated soils volume 2

Human carboxyhemoglobin bound to full-length Staphylococcus aureus IsdH - 1IsdH:2Hbdim complex

Structure of PDE5 PDE6 chimera

Nucleosome subtomogram average from chromatin droplets reconstituted with 30 bp linker DNA

Cryo-ET of non-symmetric viruses from partially irrigated soils volume 2

Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) in NTP-bound elongation state

Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) in pre-translocation elongation state

Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) in post-translocation elongation state

Cryo-EM structure of the respiratory syncytial virus polymerase (L:P) in pre-reaction elongation state

HRV14 3C in complex with single chain antibody YDF and cloverleafRNA-conformation1 splitRNA

Structure of human URAT1 bound with sulfinpyrazone

The Cryo-EM structure of human succinate dehydrogenase in complex with Benzovindiflupyr

Cryo-EM structure of the histone deacetylase complex Rpd3L in complex with mono-nucleosome

Epitope and functional classification of human neutralizing antibodies against SFTSV Gn

Cryo-EM structure of GPR151-Nb6 complex

GPR151-Legobody complex

Cryo-EM structure of dPIEZO channel

Cryo-EM structure of human Lipid Phosphate Phosphatase 2

Structural and functional basis of antinociceptive action of conotoxin AoIA at the noradrenaline transporter

Cryo-EM structure of the SPS3-FBN5 complex in a 2:2 state (class 4)

Cryo-EM structure of the SPS3-FBN5 complex in a 2:1 state

Cryo-EM structure of the N-terminal domain of Omicron BA.1 in complex with nanobody N103 and S2L20 Fab

Cryo-EM structure of the SPS3-FBN5 complex in a 2:2 state (class 2)

Human Excitatory Amino Acid Transporter 3 in 300 mM potassium and 0.1 mM Cmpd 3e in the intermediate outward-facing (iOFS) state

structure of human KCNQ1-CaM-PIP2 intermediate state

Cryo-EM structure of Vasopressin receptor 2 (V2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with OPC51803, focused on receptor

Cryo-EM structure of the Prohibitin complex from Chaetomium thermophilum

Cryo-EM structure of Lysophosphatidic acid receptor 2 (LPA2)-ARK1 with Ki16425

Cryo-EM structure of Vasopressin receptor 2 (V2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with tolvaptan

Cryo-EM structure of bradykinin B2 receptor (B2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with icatibant, focused on receptor

Cryo-EM structure of Vasopressin receptor 2 (V2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with tolvaptan, focused on receptor

Cryo-EM structure of bradykinin B2 receptor (B2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with icatibant

Cryo-EM structure of Vasopressin receptor 2 (V2R)-ARK1 with tolvaptan

Gi bound kappa-opioid receptor in complex with difelikefalin

Gi bound kappa-opioid receptor in complex with beta01

Local refinement of E. coli Complex I WT membrane domain in LMNG

Cryo-EM structure of the 70S ribosome from Francisella tularensis

Cryo-EM structure of the 70S ribosome from Francisella tularensis bound to antibiotics chloramphenicol and gentamicin

Electron tomogram of resin-embedded wild type yeast cells expressing Tcb3(1-490)-chimeraC-GFP

Cryo-EM structure of the 70S ribosome from Francisella tularensis bound to a hibernation-promoting factor

Local refinement of E. coli Complex I WT hydrophilic domain in LMNG

Local refinement of E. coli Complex I D79N NuoA mutant hydrophilic domain in LMNG

Cryo-electron tomogram of yeast cells expressing Tcb3(191-490)-chimeraC-GFP, deleted for tcb1/2, scs2/22 and ist2.

Electron tomogram of resin-embedded yeast cells expressing Tcb3(1-490)-chimeraC-GFP, deleted for tcb1/2

Electron tomogram of resin-embedded yeast cells expressing Tcb3(191-272)-chimeraC-GFP, deleted for tcb1/2, scs2/22 and ist2

Cryo-EM structure of DISC1 core

E. coli Complex I D79N NuoA mutant purified in LMNG

Electron tomogram of resin-embedded yeast cells expressing Tcb3(1-490)-chimeraC-GFP, deleted for tcb1/2, scs2/22 and ist2

Electron tomogram of resin-embedded yeast cells expressing Tcb3(1-272)-chimeraC-GFP, deleted for tcb1/2, scs2/22 and ist2

E. coli Complex I WT purified in LMNG

Electron tomogram of resin-embedded yeast cells expressing Tcb3(191-490)-GFP-chimeraC, deleted for tcb1/2, scs2/22 and ist2

Local refinement of E. coli Complex I D79N NuoA mutant membrane domain in LMNG

Structure of plant diacylglycerol O-acyltransferase 1

Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with the 3' vRNA

Crimean-Congo hemorrhagic fever virus RNA polymerase

Crimean-Congo hemorrhagic fever virus RNA polymerase in complex with the 5' vRNA

Sub-tomogram average of pre-firing AlgoCIS on the E. pacifica surface.

CryoEM structure of the baseplate iris with partial open cage in the non-contractile AlgoCIS upon low-pH treatment

Sub-tomogram average of post-firing AlgoCIS on the E. pacifica surface.

Cryo-tomogram of purified AlgoCIS incubated with E. pacifica.

CryoEM structure of the baseplate iris in the post-firing AlgoCIS upon low-pH treatment

CryoEM structure of the proximal sheath layer connected to the baseplate wedge in the contracted AlgoCIS

CryoEM structure of cap module in the contracted AlgoCIS

CryoEM structure of the baseplate iris in the pre-firing non-contractile AlgoCIS upon low-pH treatment

CryoEM structure of baseplate iris structure in the contracted AlgoCIS

CryoEM structure of one tail-fiber connected to the baseplate wedge in the contracted AlgoCIS

TMD of glutamate/glycine-bound GluN1a/2B NMDAR

Mg2+ bound GluN1a/2B NMDAR (lower)

glutamate/glycine-bound GluN1a/2B NMDAR

glycine/glutamate and Mg2+-bound GluN1a/2B NMDAR

Mg2+-bound GluN1a/2B NMDAR (upper)

glutamate/glycine and Ca2+-bound GluN1a/2B NMDAR

The Kaggle CryoET Object Identification Challenge: first place 80S ribosome

Cryo-EM structure of CRBN in complex with HBS1L and TNG-4857 (focused refinement)

Structure of Geobacillus stearothermophilus RNase P ribozyme in complex with precursor tRNA with loop-back 5' leader

The Kaggle CryoET Object Identification Challenge: first place beta-galactosidase

Structure of Geobacillus stearothermophilus RNase P ribozyme in complex with precursor tRNA with non-complementary 5' leader (Consensus)

Chimeric Escherichia coli 70S ribosome containing an evolved 16S rRNA from Vibrio cholerae (VC-ST)

The Kaggle CryoET Object Identification Challenge: first place apo-ferritin

The Kaggle CryoET Object Identification Challenge: first place virus-like-particle

Insulin Degrading Enzyme Time-resolved O/O state

Protocadherin-15 extracellular domains 1-7

The Kaggle CryoET Object Identification Challenge: first place beta-amylase

The Kaggle CryoET Object Identification Challenge: first place thyroglobulin

Crimean-Congo hemorrhagic fever virus RNA polymerase containing a 9-bp RNA product

Crimean-Congo hemorrhagic fever virus RNA polymerase containing a 15-bp RNA product

Crimean-Congo hemorrhagic fever virus RNA polymerase containing a 10-bp RNA product and incorporated 2FC

Crimean-Congo hemorrhagic fever virus RNA polymerase containing a 10-bp RNA product and incorporated cytidine

Cryo-EM structure of the GLP-1-bound human GLP-1R-Gi complex

cryoEM structure of HEP-50768-bound MRGPRX4-Gq complex

Local refine map of HEP-50768-bound MRGPRX4

local ARP-NCP structure of the ncBAF-nucleosome complex in the apo state

Cryo-EM structure of the nucleosome core particle with site-specific DNA-histone crosslinking

Cryo-EM structure of the human holo-TFIIH and XPC initial encounter complex

Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA (consensus map)

Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA (composite map)

Multi-body refinement component 2 of the cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA

Multi-body refinement component 1 of the cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA