EMD-70605
Two Component Protein Nano-Particle (T=3). De Novo Design, Computationally Relaxed into Low Resolution Single Particle CryoEM Map with Icosahedral Symmetry Applied
EMD-70605
Single-particle17.45 Å
Deposition: 13/05/2025Map released: 20/05/2026
Last modified: 15/07/2026
Sample Organism:
synthetic construct
Sample: Protein structure is equivalent to a C60 fullerene and has the general shape of a soccer ball with 12 pentagonal and 20 hexagonal facets. There are a total of 60 vertices (C3-A) and 90 edges (C2-B)
Fitted models: 9om3
Deposition Authors: DiMaio F
,
Weidle C
Sample: Protein structure is equivalent to a C60 fullerene and has the general shape of a soccer ball with 12 pentagonal and 20 hexagonal facets. There are a total of 60 vertices (C3-A) and 90 edges (C2-B)
Fitted models: 9om3
Deposition Authors: DiMaio F
,
Weidle C
De novo design of quasisymmetric two-component protein cages.
Wang S ,
Xie Y ,
Chmielewski D ,
Weidle C ,
Shu T ,
Ahn G,
Kibler RD ,
Hernandez C ,
Chen W ,
Duran DC ,
Carr A,
Bera AK ,
Lee S ,
Decarreau J,
Kang A ,
Brackenbrough E,
Joyce E ,
Wu K ,
Borst AJ ,
Favor A ,
Huang B,
DiMaio F ,
Holt LJ,
Baker D
(2026) Nature , 655 , 251 - 258
,
Xie Y ,
Chmielewski D ,
Weidle C ,
Shu T ,
Ahn G,
Kibler RD ,
Hernandez C ,
Chen W ,
Duran DC ,
Carr A,
Bera AK ,
Lee S ,
Decarreau J,
Kang A ,
Brackenbrough E,
Joyce E ,
Wu K ,
Borst AJ ,
Favor A ,
Huang B,
DiMaio F ,
Holt LJ,
Baker D
(2026) Nature , 655 , 251 - 258
Grant Support:
- Defense Threat Reduction Agency (DTRA): HDTRA1-19-1-0003 (United States)
- Burroughs Wellcome Fund: (United States)
- Human Frontier Science Program (HFSP): RGP0061/2019 (France)
- Bill & Melinda Gates Foundation: INV-043758 (United States)
- Bill & Melinda Gates Foundation: OPP1156262 (United States)
- Howard Hughes Medical Institute (HHMI): (United States)
- National Institutes of Health/National Institute on Aging (NIH/NIA): R01AG063845 (United States)
- Department of Energy (DOE, United States): KP1607011 (United States)