EMD-73857

Single-particle
2.6 Å
EMD-73857
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Deposition: 14/11/2025
Map released: 20/05/2026
Last modified: 20/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-73857
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3D volume (map.gz) Experimental metadata (xml) Experimental Metadata (cif.gz)
Map-only Validation report (pdf.gz) Map-only Validation report (cif.gz) Map-only Validation report (xml.gz)
Map and PDB model 9z6t summary report (pdf.gz) Map and 9z6t FULL report (pdf.gz)
EMICSS annotations (xml)

Human HCN1 in complex with cAMP in nanodisc

EMD-73857

Single-particle
2.6 Å
EMD-73857
3D View Gallery
Deposition: 14/11/2025
Map released: 20/05/2026
Last modified: 20/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Homotetrameric HCN1 complex (fusion with Thermostable Green Protein)
Fitted models: 9z6t

Deposition Authors: Chinn A, Chanda B
Lipid bilayers determine allostery but not intrinsic affinity of cAMP to pacemaker channels.
Idikuda V, Roy Chowdhury S, Chinn A, Chang Y, Rahman S, Ren Q, Bao H, Fu Z, Goldsmith RH, Chanda B
(2026) Nat Commun
PUBMED: 42069694
DOI: doi:10.1038/s41467-026-72591-6
ISSN: 2041-1723