EMD-54549

Single-particle
3.3 Å
EMD-54549
3D View Gallery
Deposition: 25/07/2025
Map released: 20/05/2026
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Overview 3D View Sample Experiment Validation Additional data Links

EMD-54549

Archive Files (Depositor)

Primary 3D volume (map.gz) Half-map 1 Half-map 2 (map.gz) Experimental metadata (xml) Experimental metadata (cif.gz)

Validation (wwPDB)

Map-only validation report (pdf.gz) Map-9s3r summary report (pdf.gz) Map-9s3r FULL report (pdf.gz)

EMDB Annotations

EMICSS entry mapping (xml)

EMDB Files

VA raw map (map) VA resolution mask (mrc)

Ternary complex structure of compound 1 bound to SMARCA2 bromodomain and DCAF16:DDB1deltaBPB

EMD-54549

Single-particle
3.3 Å
EMD-54549
3D View Gallery
Deposition: 25/07/2025
Map released: 20/05/2026
Last modified: 27/05/2026
Overview 3D View Sample Experiment Validation Additional data Links
Sample Organism: Homo sapiens
Sample: Ternary complex structure of compound 1 bound to SMARCA2 bromodomain and DCAF16:DDB1deltaBPB
Fitted models: 9s3r

Deposition Authors: Spiteri VA, Nakasone MA, Casement R, Iso K, Cowan AD, Ciulli A
Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation.
Spiteri VA, Segal D, Correa-Saez A, Iso K, Casement R, Munoz I Ordono M, Nakasone MA, Sathe G, Schatz C, Peters HE, Doward M, Kainacher L, Cowan AD, Ciulli A, Winter GE
(2026) Nat Chem Biol
PUBMED: 42120501
DOI: doi:10.1038/s41589-026-02224-y
ISSN: 1552-4469