EMD-54549
Ternary complex structure of compound 1 bound to SMARCA2 bromodomain and DCAF16:DDB1deltaBPB
EMD-54549
Single-particle3.3 Å
Deposition: 25/07/2025Map released: 20/05/2026
Last modified: 27/05/2026
Sample Organism:
Homo sapiens
Sample: Ternary complex structure of compound 1 bound to SMARCA2 bromodomain and DCAF16:DDB1deltaBPB
Fitted models: 9s3r
Deposition Authors: Spiteri VA, Nakasone MA
,
Casement R ,
Iso K ,
Cowan AD ,
Ciulli A
Sample: Ternary complex structure of compound 1 bound to SMARCA2 bromodomain and DCAF16:DDB1deltaBPB
Fitted models: 9s3r
Deposition Authors: Spiteri VA, Nakasone MA
,
Casement R ,
Iso K ,
Cowan AD ,
Ciulli A
Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation.
Spiteri VA,
Segal D,
Correa-Saez A ,
Iso K ,
Casement R ,
Munoz I Ordono M ,
Nakasone MA ,
Sathe G ,
Schatz C ,
Peters HE,
Doward M,
Kainacher L,
Cowan AD ,
Ciulli A ,
Winter GE
(2026) Nat Chem Biol
,
Iso K ,
Casement R ,
Munoz I Ordono M ,
Nakasone MA ,
Sathe G ,
Schatz C ,
Peters HE,
Doward M,
Kainacher L,
Cowan AD ,
Ciulli A ,
Winter GE
(2026) Nat Chem Biol
Grant Support:
- Eisai: (Japan)
- DSTT: (United Kingdom)
- H2020 Marie Curie Actions of the European Commission: 101024945 (European Union)
- European Research Council (ERC): 851478 (European Union)
- Austrian Science Fund: P7909 (Austria)
- Austrian Science Fund: P36746 (Austria)
- Austrian Science Fund: P5918723 (Austria)
- Vienna Science and Technology Fund (WWTF): LS21-015 (Austria)
- European Molecular Biology Organization (EMBO): 283-2023 (European Union)
- Innovative Medicines Initiative: 875510 (Switzerland)
- Fundacion Alfonso Martin Escudero: (Spain)
- UK Research and Innovation (UKRI): EP/Z002176/1 (United Kingdom)