$VAR1 = undef;

Summary for peptidase S01.236: kallikrein-related peptidase 6

Names
MEROPS Name	kallikrein-related peptidase 6
Other names	BSSP, kallikrein 6, KLK6 g.p. (Homo sapiens), mouse serine peptidase 18, protease M, kallikrein hK6, kallikrein 29 [obs.], myelencephalon-specific protease, MSP, neurosin, PRSS9 [obs.] g.p. (Homo sapiens), Prss18 g.p. (Mus musculus), zyme

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.236
Holotype	kallikrein-related peptidase 6 (Mus musculus) (peptidase unit: 48-270), MERNUM MER0004505
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00322
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (18 cleavages)
Activity status	human: active (Magklara et al., 2003) mouse: active (Matsui et al., 2000)
Specificity	An arginine-specific serine endopeptidase (Magklara et al., 2003).
Physiology	It is reported that neurosin has the capacity to degrade myelin-associated and other extracellular matrix proteins, and is abundantly expressed in inflammatory cells at sites of demyelination in a model of multiple sclerosis. Therefore has the potential to play a key role in immune-mediated demyelination (Blaber et al.., 2004).
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/KLK6
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/Rs/a/-/g (based on 82 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	4	12	13	1	6	4	11	22
Pro	5	4	12	1	2	2	6	3
Ala	8	5	5	0	3	14	3	3
Val	3	4	7	0	2	12	1	2
Leu	4	6	7	2	4	6	4	4
Ile	5	2	0	0	6	4	4	2
Met	0	2	0	0	4	0	4	0
Phe	3	4	9	1	3	4	2	1
Tyr	3	0	1	1	2	1	3	1
Trp	1	0	1	0	0	1	2	3
Ser	10	6	12	2	20	10	6	0
Thr	5	4	5	1	4	1	2	3
Cys	0	0	1	0	0	0	0	0
Asn	1	1	1	0	3	1	5	2
Gln	2	6	2	0	0	1	2	2
Asp	4	6	2	0	3	5	5	2
Glu	3	4	0	0	1	0	1	2
Lys	2	6	1	10	0	0	1	0
Arg	1	4	1	63	1	1	2	1
His	3	3	1	0	3	0	3	0