Literature for peptidase S01.236: kallikrein-related peptidase 6

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Boumali,R., Urli,L., Naim,M., Soualmia,F., Kinugawa,K., Petropoulos,I. and El Amri,C.
    Kallikrein-related peptidase's significance in Alzheimer's disease pathogenesis: A comprehensive survey
    Biochimie226, 77-90. PubMed  Europe PubMed DOI
  2. Finnerty,R.M., Carulli,E.M., Bernhardt,M.L., Maddison,L.A. and Winuthayanon,W.
    Deletion of Kallikrein-related peptidases ( Klks ) has no effect on fertility in mice
    MicroPubl Biol2024, PubMed  Europe PubMed DOI
  3. 2023
  4. Sananes,A., Cohen,I., Allon,I., Ben-David,O., Abu Shareb,R., Yegodayev,K.M., Stepensky,D., Elkabets,M. and Papo,N.
    Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers
    Mol Oncol17, 2337-2355. PubMed  Europe PubMed DOI
  5. Stuardo-Parada,A., Lopez-Munoz,R., Villarroel-Espindola,F., Figueroa,C.D. and Ehrenfeld,P.
    Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer
    Med Oncol40, 224-224. PubMed  Europe PubMed DOI  V
  6. 2022
  7. Baumann,A., Isak,D., Lohbeck,J., Jagtap,P.K.A., Hennig,J. and Miller,A.K.
    Scalable synthesis and structural characterization of reversible KLK6 inhibitors
    RSC Adv12, 26989-26993. PubMed  Europe PubMed DOI
  8. Bouzid,H., Soualmia,F., Oikonomopoulou,K., Soosaipillai,A., Walker,F., Louati,K., Lo Dico,R., Pocard,M., El Amri,C., Ignatenko,N.A. and Darmoul,D.
    Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer Peritoneal Metastasis
    Biomolecules12, PubMed  Europe PubMed DOI
  9. Zhang,L., Lovell,S., De Vita,E., Jagtap,P.K.A., Lucy,D., Goya Grocin,A., Kjaer,S., Borg,A., Hennig,J., Miller,A.K. and Tate,E.W.
    A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion
    J Am Chem Soc144, 22493-22504. PubMed  Europe PubMed DOI
  10. Zhao,K., Gao,M. and Lin,M.
    KLK6 Functions as an Oncogene and Unfavorable Prognostic Factor in Bladder Urothelial Carcinoma
    Dis Markers2022, 3373851-3373851. PubMed  Europe PubMed DOI
  11. 2021
  12. Ait Amiri,S., Deboux,C., Soualmia,F., Chaaya,N., Louet,M., Duplus,E., Betuing,S., Nait Oumesmar,B., Masurier,N. and El Amri,C.
    Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation
    J Med Chem64, 5667-5688. PubMed  Europe PubMed DOI
  13. Ge,Y., Zhou,C., Xiao,X., Jin,Z., Zhou,L., Chen,Z., Liu,F., Yuan,Q., Zhang,G., Shan,L. and Tong,P.
    A Novel Mutation of the KLK6 Gene in a Family With Knee Osteoarthritis
    Front Genet12, 784176-784176. PubMed  Europe PubMed DOI
  14. Zani,M.B., Sant'Ana,A.M., Tognato,R.C., Chagas,J.R. and Puzer,L.
    Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases
    Front Med (Lausanne)8, 777619-777619. PubMed  Europe PubMed DOI  V
  15. 2020
  16. Billi,A.C., Ludwig,J.E., Fritz,Y., Rozic,R., Swindell,W.R., Tsoi,L.C., Gruzska,D., Abdollahi-Roodsaz,S., Xing,X., Diaconu,D., Uppala,R., Camhi,M.I., Klenotic,P.A., Sarkar,M.K., Husni,M.E., Scher,J.U., McDonald,C., Kahlenberg,J.M., Midura,R.J., Gudjonsson,J.E. and Ward,N.L.
    KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease
    J Clin Invest130, 3151-3157. PubMed  Europe PubMed DOI
  17. Clarke,J.
    Proteinase KLK6 links skin and joint inflammation in PsA
    Nat Rev Rheumatol16, 250-250. PubMed  Europe PubMed DOI
  18. De Vita,E., Smits,N., van den Hurk,H., Beck,E.M., Hewitt,J., Baillie,G., Russell,E., Pannifer,A., Hamon,V., Morrison,A., McElroy,S.P., Jones,P., Ignatenko,N.A., Gunkel,N. and Miller,A.K.
    Synthesis and structure-activity relationships of N-(4-benzamidino)-oxazolidinones: potent and selective inhibitors of kallikrein-related peptidase 6
    ChemMedChem15, 79-95. PubMed  Europe PubMed DOI  I
  19. Mella,C., Figueroa,C.D., Otth,C. and Ehrenfeld,P.
    Involvement of Kallikrein-Related Peptidases in Nervous System Disorders
    Front Cell Neurosci14, 166-166. PubMed  Europe PubMed DOI  V
  20. Tommasi,C., Rogerson,C., Depledge,D.P., Jones,M., Naeem,A.S., Venturini,C., Frampton,D., Tutill,H.J., Way,B., Breuer,J. and O'Shaughnessy,R.F.L.
    Kallikrein-mediated cytokeratin 10 degradation is required for varicella zoster virus propagation in skin
    J Invest Dermatol140, 774-784. PubMed  Europe PubMed DOI
  21. 2019
  22. Chen,H., Sells,E., Pandey,R., Abril,E.R., Hsu,C.H., Krouse,R.S., Nagle,R.B., Pampalakis,G., Sotiropoulou,G. and Ignatenko,N.A.
    Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein
    Oncotarget10, 6062-6078. PubMed  Europe PubMed DOI
  23. Pampalakis,G., Zingkou,E., Sidiropoulos,K.G., Diamandis,E.P., Zoumpourlis,V., Yousef,G.M. and Sotiropoulou,G.
    Biochemical pathways mediated by KLK6 protease in breast cancer
    Mol Oncol13, 2329-2343. PubMed  Europe PubMed DOI
  24. Zingkou,E., Pampalakis,G., Charla,E., Nauroy,P., Kiritsi,D. and Sotiropoulou,G.
    A proinflammatory role of KLK6 protease in Netherton syndrome
    J Dermatol Sci95, 28-35. PubMed  Europe PubMed DOI
  25. 2018
  26. Andrejc,D. and Legisa,M.
    Kallikrein-related peptidase 6 can cleave human-muscle-type 6-phosphofructo-1-kinase into highly active shorter fragments
    Biochim Biophys Acta1866, 602-607. PubMed  Europe PubMed DOI
  27. De Vita,E., Schuler,P., Lovell,S., Lohbeck,J., Kullmann,S., Rabinovich,E., Sananes,A., Hessling,B., Hamon,V., Papo,N., Hess,J., Tate,E.W., Gunkel,N. and Miller,A.K.
    Depsipeptides featuring a neutral P1 are potent inhibitors of kallikrein-related peptidase 6 with on-target cellular activity
    J Med Chem61, 8859-8874. PubMed  Europe PubMed DOI  I
  28. Khoury,N., Zingkou,E., Pampalakis,G., Sofopoulos,M., Zoumpourlis,V. and Sotiropoulou,G.
    KLK6 protease accelerates skin tumor formation and progression
    Carcinogenesis39, 1529-1536. PubMed  Europe PubMed DOI  K
  29. Loessner,D., Goettig,P., Preis,S., Felber,J., Bronger,H., Clements,J.A., Dorn,J. and Magdolen,V.
    Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer
    Expert Opin Ther Targets22, 745-763. PubMed  Europe PubMed DOI  T
  30. Sananes,A., Cohen,I., Shahar,A., Hockla,A., De Vita,E., Miller,A.K., Radisky,E.S. and Papo,N.
    A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering
    J Biol Chem293, 12663-12680. PubMed  Europe PubMed DOI  S
  31. Soualmia,F., Bosc,E., Amiri,S.A., Stratmann,D., Magdolen,V., Darmoul,D., Reboud-Ravaux,M. and El Amri,C.
    Insights into the activity control of the kallikrein-related peptidase 6: small-molecule modulators and allosterism
    Biol Chem399, 1073-1078. PubMed  Europe PubMed DOI  I
  32. Yoon,H., Radulovic,M. and Scarisbrick,I.A.
    Kallikrein-related peptidase 6 orchestrates astrocyte form and function through proteinase activated receptor-dependent mechanisms
    Biol Chem399, 1041-1052. PubMed  Europe PubMed DOI
  33. 2017
  34. Adamopoulos,P.G., Kontos,C.K. and Scorilas,A.
    Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing
    Sci Rep7, 17299-17299. PubMed  Europe PubMed DOI  M
  35. Iinuma,S., Kishibe,M., Saito,N., Igawa,S., Honma,M., Bando,Y., Yoshida,S. and Ishida-Yamamoto,A.
    Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through a protease-activated receptor 2-independent mechanism
    Exp Dermatol26, 289-291. PubMed  Europe PubMed DOI
  36. Pampalakis,G., Sykioti,V.-S., Ximerakis,M., Stefanakou-Kalakou,I., Melki,R., Vekrellis,K. and Sotiropoulou,G.
    KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species
    Oncotarget8, 14502-14515. PubMed  Europe PubMed DOI
  37. Silva,R.N., Oliveira,L.C., Parise,C.B., Oliveira,J.R., Severino,B., Corvino,A., di Vaio,P., Temussi,P.A., Caliendo,G., Santagada,V., Juliano,L. and Juliano,M.A.
    Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?
    Biochim Biophys Acta1865, 558-564. PubMed  Europe PubMed DOI  P
  38. 2016
  39. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.
    Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays
    Mol Cell Proteomics15, 2863-2876. PubMed  Europe PubMed DOI  A
  40. Kishibe,M., Baida,G., Bhalla,P., Lavker,R.M., Schlosser,B., Iinuma,S., Yoshida,S., Dudley,J.T. and Budunova,I.
    Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids
    Oncotarget7, 69479-69488. PubMed  Europe PubMed DOI  K
  41. 2015
  42. Spencer,B., Valera,E., Rockenstein,E., Trejo-Morales,M., Adame,A. and Masliah,E.
    A brain-targeted, modified neurosin (kallikrein-6) reduces alpha-synuclein accumulation in a mouse model of multiple system atrophy
    Mol Neurodegener10, 48-48. PubMed  Europe PubMed DOI  U
  43. Yu,Y., Li,H., Zhang,B., Pan,X., Zhu,X., Ding,Y. and Li,G.
    Peptide network for detection of tissue-remodeling enzyme in the prognosis of hepatocellular carcinoma
    ACS Appl Mater Interfaces7, 4401-4405. PubMed  Europe PubMed DOI  A
  44. 2014
  45. Michel,N., Heuze-Vourc'h,N., Lavergne,E., Parent,C., Jourdan,M.L., Vallet,A., Iochmann,S., Musso,O., Reverdiau,P. and Courty,Y.
    Growth and survival of lung cancer cells: regulation by kallikrein-related peptidase 6 via activation of proteinase-activated receptor 2 and the epidermal growth factor receptor
    Biol Chem395, 1015-1025. PubMed  Europe PubMed DOI
  46. Miners,J., Renfrew,R., Swirski,M. and Love,S.
    Accumulation of alpha-synuclein in dementia with Lewy bodies is associated with decline in the alpha-synuclein-degrading enzymes kallikrein-6 and calpain-1
    Acta Neuropathol Commun2, 164-164. PubMed  Europe PubMed DOI
  47. Ott,C., Ainciburu,M., Parent,C., Michel,S., Roesch,C., Vourc'h,P., Corcia,P., Heuze-Vourc'h,N., Jolivet-Reynaud,C. and Courty,Y.
    Development of monoclonal antibodies to human kallikrein-related peptidase 6 (KLK6) and their use in an immunofluorometric assay for free KLK6
    Biol Chem395, 1119-1126. PubMed  Europe PubMed DOI
  48. Ximerakis,M., Pampalakis,G., Roumeliotis,T.I., Sykioti,V.S., Garbis,S.D., Stefanis,L., Sotiropoulou,G. and Vekrellis,K.
    Resistance of naturally secreted alpha-synuclein to proteolysis
    FASEB J28, 3146-3158. PubMed  Europe PubMed DOI
  49. Zhang,Y., Zhang,Z., Yang,L., Xu,B., Li,W., Tang,P., Zhang,Z., Han,N., Gao,Y., Cheng,S. and Xiao,T.
    Identification of human tissue kallikrein 6 as a potential marker of laryngeal cancer based on the relevant secretory/releasing protein database
    Dis Markers2014, 594093-594093. PubMed  Europe PubMed DOI
  50. 2013
  51. Burda,J.E., Radulovic,M., Yoon,H. and Scarisbrick,I.A.
    Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy
    Glia61, 1456-1470. PubMed  Europe PubMed DOI
  52. Lose,F., Batra,J., O'Mara,T., Fahey,P., Marquart,L., Eeles,R.A., Easton,D.F., Al Olama,A.A., Kote-Jarai,Z., Guy,M., Muir,K., Lophatananon,A., Rahman,A.A., Neal,D.E., Hamdy,F.C., Donovan,J.L., Chambers,S., Gardiner,R.A., Aitken,J.F., Yaxley,J., Alexander,K., Clements,J.A., Spurdle,A.B. and Kedda,M.A.
    Common variation in kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness
    Urol Oncol31, 635-643. PubMed  Europe PubMed DOI  M
  53. Lundwall,A.
    Old genes and new genes: The evolution of the kallikrein locus
    Thromb Haemost110, 469-475. PubMed  Europe PubMed DOI  V
  54. Spencer,B., Michael,S., Shen,J., Kosberg,K., Rockenstein,E., Patrick,C., Adame,A. and Masliah,E.
    Lentivirus mediated delivery of neurosin promotes clearance of wild-type alpha-synuclein and reduces the pathology in an alpha-synuclein model of LBD
    Mol Ther21, 31-41. PubMed  Europe PubMed DOI  U
  55. Yoon,H., Radulovic,M., Wu,J., Blaber,S.I., Blaber,M., Fehlings,M.G. and Scarisbrick,I.A.
    Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity
    J Neurochem127, 283-298. PubMed  Europe PubMed DOI
  56. 2012
  57. Arnold,S., Pampalakis,G., Kantiotou,K., Silva,D., Cortez,C., Missailidis,S. and Sotiropoulou,G.
    One round of SELEX for the generation of DNA aptamers directed against KLK6
    Biol Chem393, 343-353. PubMed  Europe PubMed DOI  I
  58. Bayani,J. and Diamandis,E.P.
    The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6)
    Clin Chem Lab Med50, 211-233. PubMed  Europe PubMed DOI  V
  59. Clements,J.A., Hooper,J.D. and Dong,Y.
    The human tissue kallikrein and kallikrein-related peptidase family
    [ISSN:978-0-12-407742-3]3, 2747-2756. DOI
  60. Liang,G., Chen,X., Aldous,S., Pu,S.F., Mehdi,S., Powers,E., Xia,T. and Wang,R.
    Human kallikrein 6 inhibitors with a para-amidobenzylanmine P1 group identified through virtual screening
    Bioorg Med Chem Lett22, 2450-2455. PubMed  Europe PubMed DOI  S  I
  61. Liang,G., Chen,X., Aldous,S., Pu,S.F., Mehdi,S., Powers,E., Giovanni,A., Kongsamut,S., Xia,T., Zhang,Y., Wang,R., Gao,Z., Merriman,G., McLean,L.R. and Morize,I.
    Virtual screening and X-ray crystallography for human kallikrein 6 inhibitors with an amidinothiophene P1 group
    ACS Med Chem Lett3, 159-164. PubMed  Europe PubMed DOI  S  I
  62. Scarisbrick,I.A. and Blaber,M.
    Kallikrein-related peptidase 6
    [ISSN:978-0-12-407742-3]3, 2778-2788. DOI
  63. Scarisbrick,I.A., Yoon,H., Panos,M., Larson,N., Blaber,S.I., Blaber,M. and Rodriguez,M.
    Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis
    Brain Pathol22, 709-722. PubMed  Europe PubMed DOI
  64. Scarisbrick,I.A., Radulovic,M., Burda,J.E., Larson,N., Blaber,S.I., Giannini,C., Blaber,M. and Vandell,A.G.
    Kallikrein 6 is a novel molecular trigger of reactive astrogliosis
    Biol Chem393, 355-367. PubMed  Europe PubMed DOI
  65. Watanabe,Y. and Tanaka,M.
    Physiological functions and pathology of neurosin/kallikrein 6 in the central nervous system
    Proteomics Res J3, 287-295.
  66. 2011
  67. Scarisbrick,I.A., Epstein,B., Cloud,B.A., Yoon,H., Wu,J., Renner,D.N., Blaber,S.I., Blaber,M., Vandell,A.G. and Bryson,A.L.
    Functional role of kallikrein 6 in regulating immune cell survival
    PLoS ONE6, e18376-e18376. PubMed  Europe PubMed DOI
  68. 2010
  69. Angelopoulou,K. and Karagiannis,G.S.
    Structural characterization and expression of five novel canine kallikrein-related peptidases in mammary cancer
    Mamm Genome21, 516-524. PubMed  Europe PubMed DOI
  70. Ashby,E.L., Kehoe,P.G. and Love,S.
    Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia
    Brain Res1363, 1-10. PubMed  Europe PubMed DOI
  71. Tatebe,H., Watanabe,Y., Kasai,T., Mizuno,T., Nakagawa,M., Tanaka,M. and Tokuda,T.
    Extracellular neurosin degrades alpha-synuclein in cultured cells
    Neurosci Res67, 341-346. PubMed  Europe PubMed DOI
  72. 2009
  73. Pampalakis,G., Prosnikli,E., Agalioti,T., Vlahou,A., Zoumpourlis,V. and Sotiropoulou,G.
    A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition
    Cancer Res69, 3779-3787. PubMed  Europe PubMed DOI
  74. 2008
  75. Clements,J.A.
    Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?
    Biol Chem389, 1447-1454. PubMed  Europe PubMed DOI  V
  76. Debela,M., Beaufort,N., Magdolen,V., Schechter,N.M., Craik,C.S., Schmitt,M., Bode,W. and Goettig,P.
    Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7
    Biol Chem389, 623-632. PubMed  Europe PubMed DOI  P  S
  77. Kasai,T., Tokuda,T., Yamaguchi,N., Watanabe,Y., Kametani,F., Nakagawa,M. and Mizuno,T.
    Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro
    Neurosci Lett436, 52-56. PubMed  Europe PubMed DOI  P
  78. Kountourakis,P., Psyrri,A., Scorilas,A., Camp,R., Markakis,S., Kowalski,D., Diamandis,E.P. and Dimopoulos,M.A.
    Prognostic value of kallikrein-related peptidase 6 protein expression levels in advanced ovarian cancer evaluated by automated quantitative analysis (AQUA)
    Cancer Sci99, 2224-2229. PubMed  Europe PubMed DOI
  79. Li,H.X., Hwang,B.Y., Laxmikanthan,G., Blaber,S.I., Blaber,M., Golubkov,P.A., Ren,P., Iverson,B.L. and Georgiou,G.
    Substrate specificity of human kallikreins 1 and 6 determined by phage display
    Protein Sci17, 664-672. PubMed  Europe PubMed DOI  P
  80. Oikonomopoulou,K., Hansen,K.K., Baruch,A., Hollenberg,M.D. and Diamandis,E.P.
    Immunofluorometric activity-based probe analysis of active KLK6 in biological fluids
    Biol Chem389, 747-756. PubMed  Europe PubMed DOI
  81. Pampalakis,G., Arampatzidou,M., Amoutzias,G., Kossida,S. and Sotiropoulou,G.
    Identification and analysis of mammalian KLK6 orthologue genes for prediction of physiological substrates
    Comput Biol Chem32, 111-121. PubMed  Europe PubMed DOI
  82. Sharma,N., Oikonomopoulou,K., Ito,K., Renaux,B., Diamandis,E.P., Hollenberg,M.D. and Rancourt,D.E.
    Substrate specificity determination of mouse implantation serine proteinase and human kallikrein-related peptidase 6 by phage display
    Biol Chem389, 1097-1105. PubMed  Europe PubMed DOI  P
  83. Wang,Y., Luo,W. and Reiser,G.
    Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions
    Cell Mol Life Sci65, 237-252. PubMed  Europe PubMed DOI  V
  84. Yoon,H., Blaber,S.I., Evans,D.M., Trim,J., Juliano,M.A., Scarisbrick,I.A. and Blaber,M.
    Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis
    Protein Sci17, 1998-2007. PubMed  Europe PubMed DOI
  85. 2007
  86. Blaber,S.I., Yoon,H., Scarisbrick,I.A., Juliano,M.A. and Blaber,M.
    The autolytic regulation of human kallikrein-related peptidase 6
    Biochemistry46, 5209-5217. PubMed  Europe PubMed DOI
  87. Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U.
    Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis
    Genomics89, 429-438. PubMed  Europe PubMed DOI
  88. Klucky,B., Mueller,R., Vogt,I., Teurich,S., Hartenstein,B., Breuhahn,K., Flechtenmacher,C., Angel,P. and Hess,J.
    Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion
    Cancer Res67, 8198-8206. PubMed  Europe PubMed DOI
  89. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.
    Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    J Biol Chem282, 31852-31864. PubMed  Europe PubMed DOI  V
  90. 2006
  91. Angelo,P.F., Lima,A.R., Alves,F.M., Blaber,S.I., Scarisbrick,I.A., Blaber,M., Juliano,L. and Juliano,M.A.
    Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects
    J Biol Chem281, 3116-3126. PubMed  Europe PubMed DOI  P
  92. [YEAR:25-9-2006]Bando,Y., Ito,S., Nagai,Y., Terayama,R., Kishibe,M., Jiang,Y.P., Mitrovic,B., Takahashi,T. and Yoshida,S.
    Implications of protease M/neurosin in myelination during experimental demyelination and remyelination
    Neurosci Lett405, 175-180. PubMed  Europe PubMed DOI
  93. [YEAR:14-11-2006]Darling,M.R., Jackson-Boeters,L., Daley,T.D. and Diamandis,E.P.
    Human kallikrein 6 expression in salivary gland tumors
    J Histochem Cytochem54, 337-342. PubMed  Europe PubMed DOI
  94. [YEAR:1-6-2006]Debela,M., Magdolen,V., Schechter,N., Valachova,M., Lottspeich,F., Craik,C.S., Choe,Y., Bode,W. and Goettig,P.
    Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
    J Biol Chem281, 25678-25688. PubMed  Europe PubMed DOI  P
  95. Heuze-Vourc'h,N., Ainciburu,M., Planque,C., Brillard-Bourdet,M., Ott,C., Jolivet-Reynaud,C. and Courty,Y.
    Recombinant kallikrein expression: site-specific integration for hK6 production in human cells
    Biol Chem387, 687-695. PubMed  Europe PubMed DOI  E
  96. Pampalakis,G. and Sotiropoulou,G.
    Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer
    Biol Chem387, 773-782. PubMed  Europe PubMed DOI
  97. Prezas,P., Arlt,M.J., Viktorov,P., Soosaipillai,A., Holzscheiter,L., Schmitt,M., Talieri,M., Diamandis,E.P., Kruger,A. and Magdolen,V.
    Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells
    Biol Chem387, 807-811. PubMed  Europe PubMed DOI
  98. Scarisbrick,I.A., Sabharwal,P., Cruz,H., Larsen,N., Vandell,A.G., Blaber,S.I., Ameenuddin,S., Papke,L.M., Fehlings,M.G., Reeves,R.K., Blaber,M., Windebank,A.J. and Rodriguez,M.
    Dynamic role of kallikrein 6 in traumatic spinal cord injury
    Eur J Neurosci24, 1457-1469. PubMed  Europe PubMed DOI
  99. 2005
  100. [YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P.
    A survey of alternative transcripts of human tissue kallikrein genes
    Biochim Biophys Acta1755, 1-14. PubMed  Europe PubMed DOI  R
  101. [YEAR:1-10-2005]Nagahara,H., Mimori,K., Utsunomiya,T., Barnard,G.F., Ohira,M., Hirakawa,K. and Mori,M.
    Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer
    Clin Cancer Res11, 6800-6806. PubMed  Europe PubMed DOI
  102. [YEAR:15-4-2005]Ogawa,K., Utsunomiya,T., Mimori,K., Tanaka,F., Inoue,H., Nagahara,H., Murayama,S. and Mori,M.
    Clinical significance of human kallikrein gene 6 messenger RNA expression in colorectal cancer
    Clin Cancer Res11, 2889-2893. PubMed  Europe PubMed DOI
  103. Oka,Y., Uchida,A., Aoyama,M., Fujita,M., Hotta,N., Tada,T., Katano,H., Mase,M., Asai,K. and Yamada,K.
    Expression of myelencephalon-specific protease after cryogenic lesioning of the rat parietal cortex
    J Neurotrauma22, 501-510. PubMed  Europe PubMed DOI
  104. [YEAR:1-7-2005]Terayama,R., Bando,Y., Jiang,Y.P., Mitrovic,B. and Yoshida,S.
    Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis
    Neurosci Lett382, 82-87. PubMed  Europe PubMed DOI
  105. 2004
  106. Bayes,A., Tsetsenis,T., Ventura,S., Vendrell,J., Aviles,F.X. and Sotiropoulou,G.
    Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation
    Biol Chem385, 517-524. PubMed  Europe PubMed DOI
  107. Blaber,S.I., Ciric,B., Christophi,G.P., Bernett,M.J., Blaber,M., Rodriguez,M. and Scarisbrick,I.A.
    Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease
    FASEB J18, 920-922. PubMed  Europe PubMed DOI
  108. Christophi,G.P., Isackson,P.J., Blaber,S., Blaber,M., Rodriguez,M. and Scarisbrick,I.A.
    Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease
    J Neurochem91, 1439-1449. PubMed  Europe PubMed DOI
  109. Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y.
    The tissue kallikrein gene cluster
    [ISSN:0-12-079610-4]2, 1569-1577.  V
  110. Ghosh,M.C., Grass,L., Soosaipillai,A., Sotiropoulou,G. and Diamandis,E.P.
    Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells
    Tumour Biol25, 193-199. PubMed  Europe PubMed DOI
  111. [YEAR:16-8-2004]Ni,X., Zhang,W., Huang,K.C., Wang,Y., Ng,S.K., Mok,S.C., Berkowitz,R.S. and Ng,S.W.
    Characterisation of human kallikrein 6/protease M expression in ovarian cancer
    Br J Cancer91, 725-731. PubMed  Europe PubMed DOI
  112. [YEAR:16-7-2004]Pampalakis,G., Kurlender,L., Diamandis,E.P. and Sotiropoulou,G.
    Cloning and characterization of novel isoforms of the human kallikrein 6 gene
    Biochem Biophys Res Commun320, 54-61. PubMed  Europe PubMed DOI
  113. Scarisbrick,I.A., Blaber,S.I. and Blaber,M.
    Myelencephalon-specific protease
    [ISSN:0-12-079610-4]2, 1587-1591.  V
  114. Terayama,R., Bando,Y., Takahashi,T. and Yoshida,S.
    Differential expression of neuropsin and protease M/neurosin in oligodendrocytes after injury to the spinal cord
    Glia48, 91-101. PubMed  Europe PubMed DOI
  115. [YEAR:26-7-2004]Uchida,A., Oka,Y., Aoyama,M., Suzuki,S., Yokoi,T., Katano,H., Mase,M., Tada,T., Asai,K. and Yamada,K.
    Expression of myelencephalon-specific protease in transient middle cerebral artery occlusion model of rat brain
    Brain Res Mol Brain Res126, 129-136. PubMed  Europe PubMed DOI
  116. Yamaguchi,N.
    Neurosin or human kallikrein 6
    [ISSN:0-12-079610-4]2, 1585-1587.  V
  117. Yousef,G.M., Borgono,C.A., White,N.M., Robb,J.D., Michael,I.P., Oikonomopoulou,K., Khan,S. and Diamandis,E.P.
    In silico analysis of the human kallikrein gene 6
    Tumour Biol25, 282-289. PubMed  Europe PubMed DOI
  118. 2003
  119. [YEAR:15-3-2003]Diamandis,E.P., Scorilas,A., Fracchioli,S., Van Gramberen,M., De Bruijn,H., Henrik,A., Soosaipillai,A., Grass,L., Yousef,G.M., Stenman,U.H., Massobrio,M., Van Der Zee,A.G., Vergote,I. and Katsaros,D.
    Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma
    J Clin Oncol21, 1035-1043. PubMed  Europe PubMed DOI
  120. Hutchinson,S., Luo,L.Y., Yousef,G.M., Soosaipillai,A. and Diamandis,E.P.
    Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin
    Clin Chem49, 746-751. PubMed  Europe PubMed DOI
  121. [YEAR:15-10-2003]Iwata,A., Maruyama,M., Akagi,T., Hashikawa,T., Kanazawa,I., Tsuji,S. and Nukina,N.
    Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies
    Hum Mol Genet12, 2625-2635. PubMed  Europe PubMed DOI
  122. [YEAR:8-8-2003]Magklara,A., Mellati,A.A., Wasney,G.A., Little,S.P., Sotiropoulou,G., Becker,G.W. and Diamandis,E.P.
    Characterization of the enzymatic activity of human kallikrein 6: autoactivation, substrate specificity, and regulation by inhibitors
    Biochem Biophys Res Commun307, 948-955. PubMed  Europe PubMed DOI
  123. [YEAR:1-5-2003]Yousef,G.M., Polymeris,M.E., Yacoub,G.M., Scorilas,A., Soosaipillai,A., Popalis,C., Fracchioli,S., Katsaros,D. and Diamandis,E.P.
    Parallel overexpression of seven kallikrein genes in ovarian cancer
    Cancer Res63, 2223-2227. PubMed  Europe PubMed
  124. 2002
  125. [YEAR:5-7-2002]Bernett,M.J., Blaber,S.I., Scarisbrick,I.A., Dhanarajan,P., Thompson,S.M. and Blaber,M.
    Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system
    J Biol Chem277, 24562-24570. PubMed  Europe PubMed DOI  S
  126. [YEAR:29-1-2002]Blaber,S.I., Scarisbrick,I.A., Bernett,M.J., Dhanarajan,P., Seavy,M.A., Jin,Y., Schwartz,M.A., Rodriguez,M. and Blaber,M.
    Enzymatic properties of rat myelencephalon-specific protease
    Biochemistry41, 1165-1173. PubMed  Europe PubMed DOI
  127. [YEAR:26-7-2002]Gomis-Ruth,F.X., Bayes,A., Sotiropoulou,G., Pampalakis,G., Tsetsenis,T., Villegas,V., Aviles,F.X. and Coll,M.
    The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family
    J Biol Chem277, 27273-27281. PubMed  Europe PubMed DOI  S
  128. Scarisbrick,I.A., Blaber,S.I., Lucchinetti,C.F., Genain,C.P., Blaber,M. and Rodriguez,M.
    Activity of a newly identified serine protease in CNS demyelination
    Brain125, 1283-1296. PubMed  Europe PubMed
  129. [YEAR:26-4-2002]Yokoi,T., Yamamoto,N., Tada,T., Fujita,M., Moriyama,A., Matsui,H., Takahashi,T., Togari,H., Kato,T. and Asai,K.
    Developmental changes and localization of mouse brain serine proteinase mRNA and protein in mouse brain
    Neurosci Lett323, 133-136. PubMed  Europe PubMed DOI
  130. 2001
  131. Breitenbach,U., Tuckermann,J.P., Gebhardt,C., Richter,K.H., rstenberger,G., Christofori,G. and Angel,P.
    Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis
    J Invest Dermatol117, 634-640. PubMed  Europe PubMed DOI
  132. Clements,J., Hooper,J., Dong,Y. and Harvey,T.
    The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions
    Biol Chem382, 5-14. PubMed  Europe PubMed DOI  V
  133. [YEAR:25-5-2001]Okui,A., Kominami,K., Uemura,H., Mitsui,S. and Yamaguchi,N.
    Characterization of a brain-related serine protease, neurosin (human kaillikrein 6), in human cerebrospinal fluid
    Neuroreport12, 1345-1350. PubMed  Europe PubMed
  134. Petraki,C.D., Karavana,V.N., Skoufogiannis,P.T., Little,S.P., Howarth,D.J., Yousef,G.M. and Diamandis,E.P.
    The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry
    J Histochem Cytochem49, 1431-1441. PubMed  Europe PubMed
  135. [YEAR:12-3-2001]Scarisbrick,I.A., Isackson,P.J., Ciric,B., Windebank,A.J. and Rodriguez,M.
    MSP, a trypsin-like serine protease, is abundantly expressed in the human nervous system
    J Comp Neurol431, 347-361. PubMed  Europe PubMed DOI
  136. Tanimoto,H., Underwood,L.J., Shigemasa,K., Parmley,T.H. and O'Brien,T.J.
    Increased expression of protease M in ovarian tumors
    Tumour Biol22, 11-18. PubMed  Europe PubMed
  137. 2000
  138. Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V.
    The new human kallikrein gene family: implications in carcinogenesis
    Trends Endocrinol Metab11, 54-60. PubMed  Europe PubMed DOI
  139. Diamandis,E.P., Yousef,G.M., Soosaipillai,A.R., Grass,L., Porter,A., Little,S. and Sotiropoulou,G.
    Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications
    Clin Biochem33, 369-375. PubMed  Europe PubMed DOI  A
  140. Diamandis,E.P., Yousef,G.M., Soosaipillai,A.R. and Bunting,P.
    Human kallikrein 6 (zyme/protease M/neurosin): A new serum biomarker of ovarian carcinoma
    Clin Biochem33, 579-583. PubMed  Europe PubMed DOI
  141. Diamandis,E.P., Yousef,G.M., Petraki,C. and Soosaipillai,A.R.
    Human kallikrein 6 as a biomarker of Alzheimer's disease
    Clin Biochem33, 663-667. PubMed  Europe PubMed DOI
  142. [YEAR:14-4-2000]Matsui,H., Kimura,A., Yamashiki,N., Moriyama,A., Kaya,M., Yoshida,I., Takagi,N. and Takahashi,T.
    Molecular and biochemical characterization of a serine proteinase predominantly expressed in the medulla oblongata and cerebellar white matter of mouse brain
    J Biol Chem275, 11050-11057. PubMed  Europe PubMed DOI
  143. Ogawa,K., Yamada,T., Tsujioka,Y., Taguchi,J., Takahashi,M., Tsuboi,Y., Fujino,Y., Nakajima,M., Yamamoto,T., Akatsu,H., Mitsui,S. and Yamaguchi,N.
    Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease
    Psychiatry Clin Neurosci54, 419-426. PubMed  Europe PubMed DOI
  144. Scarisbrick,I.A., Asakura,K., Blaber,S., Blaber,M., Isackson,P.J., Bieto,T., Rodriguez,M. and Windebank,A.J.
    Preferential expression of myelencephalon-specific protease by oligodendrocytes of the adult rat spinal cord white matter
    Glia30, 219-230. PubMed  Europe PubMed DOI
  145. 1999
  146. [YEAR:10-5-1999]Meier,N., Dear,T.N. and Boehm,T.
    A novel serine protease overexpressed in the hair follicles of nude mice
    Biochem Biophys Res Commun258, 374-378. PubMed  Europe PubMed DOI
  147. [YEAR:25-8-1999]Yamanaka,H., He,X., Matsumoto,K., Shiosaka,S. and Yoshida,S.
    Protease M/neurosin mRNA is expressed in mature oligodendrocytes
    Brain Res Mol Brain Res71, 217-224. PubMed  Europe PubMed DOI
  148. [YEAR:1-12-1999]Yousef,G.M., Luo,L.Y., Scherer,S.W., Sotiropoulou,G. and Diamandis,E.P.
    Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease
    Genomics62, 251-259. PubMed  Europe PubMed DOI
  149. 1997
  150. Little,S.P., Dixon,E.P., Norris,F., Buckley,W., Becker,G.W., Johnson,M., Dobbins,J.R., Wyrick,T., Miller,J.R., MacKellar,W., Hepburn,D., Corvalan,J., McClure,D., Liu,X., Stephenson,D., Clemens,J. and Johnstone,E.M.
    Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain
    J Biol Chem272, 25135-25142. PubMed  Europe PubMed DOI
  151. Scarisbrick,I.A., Towner,M.D. and Isackson,P.J.
    Nervous system-specific expression of a novel serine protease: Regulation in the adult rat spinal cord by excitotoxic injury
    J Neurosci17, 8156-8168. PubMed  Europe PubMed
  152. Yamashiro,K., Tsuruoka,N., Kodama,S., Tsujimoto,M., Yamamura,Y., Tanaka,T., Nakazato,H. and Yamaguchi,N.
    Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain
    Biochim Biophys Acta1350, 11-14. PubMed  Europe PubMed DOI
  153. 1996
  154. Anisowicz,A., Sotiropoulou,G., Stenman,G., Mok,S.C. and Sager,R.
    A novel protease homolog differentially expressed in breast and ovarian cancer
    Mol Med2, 624-636. PubMed  Europe PubMed