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Literature for peptidase S01.236: kallikrein-related peptidase 6

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Zingkou,E., Bisyris,E., Pampalakis,G. and Sotiropoulou,G.
    Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing
    J Pathol (2026) PubMed  Europe PubMed DOI
    2. 2025
  2. O'Neill,K.L., Zigmond,J.W. and Bergan,R.
    HSP90alpha and KLK6 Co-Regulate Stress-Induced Prostate Cancer Cell Motility
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC  K  L
    3. 2024
  3. Boumali,R., Urli,L., Naim,M., Soualmia,F., Kinugawa,K., Petropoulos,I. and El Amri,C.
    Kallikrein-related peptidase's significance in Alzheimer's disease pathogenesis: A comprehensive survey
    Biochimie (2024) 226, 77-90. PubMed  Europe PubMed DOI
  4. Finnerty,R.M., Carulli,E.M., Bernhardt,M.L., Maddison,L.A. and Winuthayanon,W.
    Deletion of Kallikrein-related peptidases ( Klks ) has no effect on fertility in mice
    MicroPubl Biol (2024) 2024 PubMed  Europe PubMed DOI  PMC  EPMC
    5. 2023
  5. Sananes,A., Cohen,I., Allon,I., Ben-David,O., Abu Shareb,R., Yegodayev,K.M., Stepensky,D., Elkabets,M. and Papo,N.
    Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers
    Mol Oncol (2023) 17, 2337-2355. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Stuardo-Parada,A., Lopez-Munoz,R., Villarroel-Espindola,F., Figueroa,C.D. and Ehrenfeld,P.
    Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer
    Med Oncol (2023) 40, 224-224. PubMed  Europe PubMed DOI  V
    7. 2022
  7. Baumann,A., Isak,D., Lohbeck,J., Jagtap,P.K.A., Hennig,J. and Miller,A.K.
    Scalable synthesis and structural characterization of reversible KLK6 inhibitors
    RSC Adv (2022) 12, 26989-26993. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Bouzid,H., Soualmia,F., Oikonomopoulou,K., Soosaipillai,A., Walker,F., Louati,K., Lo Dico,R., Pocard,M., El Amri,C., Ignatenko,N.A. and Darmoul,D.
    Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer Peritoneal Metastasis
    Biomolecules (2022) 12 PubMed  Europe PubMed DOI  PMC  EPMC
  9. Zhang,L., Lovell,S., De Vita,E., Jagtap,P.K.A., Lucy,D., Goya Grocin,A., Kjaer,S., Borg,A., Hennig,J., Miller,A.K. and Tate,E.W.
    A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion
    J Am Chem Soc (2022) 144, 22493-22504. PubMed  Europe PubMed DOI  PMC  EPMC
  10. Zhao,K., Gao,M. and Lin,M.
    KLK6 Functions as an Oncogene and Unfavorable Prognostic Factor in Bladder Urothelial Carcinoma
    Dis Markers (2022) 2022, 3373851-3373851. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2021
  11. Ait Amiri,S., Deboux,C., Soualmia,F., Chaaya,N., Louet,M., Duplus,E., Betuing,S., Nait Oumesmar,B., Masurier,N. and El Amri,C.
    Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation
    J Med Chem (2021) 64, 5667-5688. PubMed  Europe PubMed DOI
  12. Ge,Y., Zhou,C., Xiao,X., Jin,Z., Zhou,L., Chen,Z., Liu,F., Yuan,Q., Zhang,G., Shan,L. and Tong,P.
    A Novel Mutation of the KLK6 Gene in a Family With Knee Osteoarthritis
    Front Genet (2021) 12, 784176-784176. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Zani,M.B., Sant'Ana,A.M., Tognato,R.C., Chagas,J.R. and Puzer,L.
    Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases
    Front Med (Lausanne) (2021) 8, 777619-777619. PubMed  Europe PubMed DOI  PMC  EPMC  V
    14. 2020
  14. Billi,A.C., Ludwig,J.E., Fritz,Y., Rozic,R., Swindell,W.R., Tsoi,L.C., Gruzska,D., Abdollahi-Roodsaz,S., Xing,X., Diaconu,D., Uppala,R., Camhi,M.I., Klenotic,P.A., Sarkar,M.K., Husni,M.E., Scher,J.U., McDonald,C., Kahlenberg,J.M., Midura,R.J., Gudjonsson,J.E. and Ward,N.L.
    KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease
    J Clin Invest (2020) 130, 3151-3157. PubMed  Europe PubMed DOI
  15. Clarke,J.
    Proteinase KLK6 links skin and joint inflammation in PsA
    Nat Rev Rheumatol (2020) 16, 250-250. PubMed  Europe PubMed DOI
  16. De Vita,E., Smits,N., van den Hurk,H., Beck,E.M., Hewitt,J., Baillie,G., Russell,E., Pannifer,A., Hamon,V., Morrison,A., McElroy,S.P., Jones,P., Ignatenko,N.A., Gunkel,N. and Miller,A.K.
    Synthesis and structure-activity relationships of N-(4-benzamidino)-oxazolidinones: potent and selective inhibitors of kallikrein-related peptidase 6
    ChemMedChem (2020) 15, 79-95. PubMed  Europe PubMed DOI  I
  17. Mella,C., Figueroa,C.D., Otth,C. and Ehrenfeld,P.
    Involvement of Kallikrein-Related Peptidases in Nervous System Disorders
    Front Cell Neurosci (2020) 14, 166-166. PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Tommasi,C., Rogerson,C., Depledge,D.P., Jones,M., Naeem,A.S., Venturini,C., Frampton,D., Tutill,H.J., Way,B., Breuer,J. and O'Shaughnessy,R.F.L.
    Kallikrein-mediated cytokeratin 10 degradation is required for varicella zoster virus propagation in skin
    J Invest Dermatol (2020) 140, 774-784. PubMed  Europe PubMed DOI
    19. 2019
  19. Chen,H., Sells,E., Pandey,R., Abril,E.R., Hsu,C.H., Krouse,R.S., Nagle,R.B., Pampalakis,G., Sotiropoulou,G. and Ignatenko,N.A.
    Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein
    Oncotarget (2019) 10, 6062-6078. PubMed  Europe PubMed DOI  PMC  EPMC
  20. Pampalakis,G., Zingkou,E., Sidiropoulos,K.G., Diamandis,E.P., Zoumpourlis,V., Yousef,G.M. and Sotiropoulou,G.
    Biochemical pathways mediated by KLK6 protease in breast cancer
    Mol Oncol (2019) 13, 2329-2343. PubMed  Europe PubMed DOI
  21. Zingkou,E., Pampalakis,G., Charla,E., Nauroy,P., Kiritsi,D. and Sotiropoulou,G.
    A proinflammatory role of KLK6 protease in Netherton syndrome
    J Dermatol Sci (2019) 95, 28-35. PubMed  Europe PubMed DOI
    22. 2018
  22. Andrejc,D. and Legisa,M.
    Kallikrein-related peptidase 6 can cleave human-muscle-type 6-phosphofructo-1-kinase into highly active shorter fragments
    Biochim Biophys Acta (2018) 1866, 602-607. PubMed  Europe PubMed DOI
  23. De Vita,E., Schuler,P., Lovell,S., Lohbeck,J., Kullmann,S., Rabinovich,E., Sananes,A., Hessling,B., Hamon,V., Papo,N., Hess,J., Tate,E.W., Gunkel,N. and Miller,A.K.
    Depsipeptides featuring a neutral P1 are potent inhibitors of kallikrein-related peptidase 6 with on-target cellular activity
    J Med Chem (2018) 61, 8859-8874. PubMed  Europe PubMed DOI  I
  24. Khoury,N., Zingkou,E., Pampalakis,G., Sofopoulos,M., Zoumpourlis,V. and Sotiropoulou,G.
    KLK6 protease accelerates skin tumor formation and progression
    Carcinogenesis (2018) 39, 1529-1536. PubMed  Europe PubMed DOI  K
  25. Loessner,D., Goettig,P., Preis,S., Felber,J., Bronger,H., Clements,J.A., Dorn,J. and Magdolen,V.
    Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer
    Expert Opin Ther Targets (2018) 22, 745-763. PubMed  Europe PubMed DOI  T
  26. Sananes,A., Cohen,I., Shahar,A., Hockla,A., De Vita,E., Miller,A.K., Radisky,E.S. and Papo,N.
    A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering
    J Biol Chem (2018) 293, 12663-12680. PubMed  Europe PubMed DOI  S
  27. Soualmia,F., Bosc,E., Amiri,S.A., Stratmann,D., Magdolen,V., Darmoul,D., Reboud-Ravaux,M. and El Amri,C.
    Insights into the activity control of the kallikrein-related peptidase 6: small-molecule modulators and allosterism
    Biol Chem (2018) 399, 1073-1078. PubMed  Europe PubMed DOI  I
  28. Yoon,H., Radulovic,M. and Scarisbrick,I.A.
    Kallikrein-related peptidase 6 orchestrates astrocyte form and function through proteinase activated receptor-dependent mechanisms
    Biol Chem (2018) 399, 1041-1052. PubMed  Europe PubMed DOI
    29. 2017
  29. Adamopoulos,P.G., Kontos,C.K. and Scorilas,A.
    Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing
    Sci Rep (2017) 7, 17299-17299. PubMed  Europe PubMed DOI  PMC  EPMC  M
  30. Iinuma,S., Kishibe,M., Saito,N., Igawa,S., Honma,M., Bando,Y., Yoshida,S. and Ishida-Yamamoto,A.
    Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through a protease-activated receptor 2-independent mechanism
    Exp Dermatol (2017) 26, 289-291. PubMed  Europe PubMed DOI
  31. Pampalakis,G., Sykioti,V.-S., Ximerakis,M., Stefanakou-Kalakou,I., Melki,R., Vekrellis,K. and Sotiropoulou,G.
    KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species
    Oncotarget (2017) 8, 14502-14515. PubMed  Europe PubMed DOI
  32. Silva,R.N., Oliveira,L.C., Parise,C.B., Oliveira,J.R., Severino,B., Corvino,A., di Vaio,P., Temussi,P.A., Caliendo,G., Santagada,V., Juliano,L. and Juliano,M.A.
    Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?
    Biochim Biophys Acta (2017) 1865, 558-564. PubMed  Europe PubMed DOI  P
    33. 2016
  33. Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P.
    Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays
    Mol Cell Proteomics (2016) 15, 2863-2876. PubMed  Europe PubMed DOI  A
  34. Kishibe,M., Baida,G., Bhalla,P., Lavker,R.M., Schlosser,B., Iinuma,S., Yoshida,S., Dudley,J.T. and Budunova,I.
    Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids
    Oncotarget (2016) 7, 69479-69488. PubMed  Europe PubMed DOI  K
    35. 2015
  35. Spencer,B., Valera,E., Rockenstein,E., Trejo-Morales,M., Adame,A. and Masliah,E.
    A brain-targeted, modified neurosin (kallikrein-6) reduces alpha-synuclein accumulation in a mouse model of multiple system atrophy
    Mol Neurodegener (2015) 10, 48-48. PubMed  Europe PubMed DOI  PMC  EPMC  U
  36. Yu,Y., Li,H., Zhang,B., Pan,X., Zhu,X., Ding,Y. and Li,G.
    Peptide network for detection of tissue-remodeling enzyme in the prognosis of hepatocellular carcinoma
    ACS Appl Mater Interfaces (2015) 7, 4401-4405. PubMed  Europe PubMed DOI  A
    37. 2014
  37. Michel,N., Heuze-Vourc'h,N., Lavergne,E., Parent,C., Jourdan,M.L., Vallet,A., Iochmann,S., Musso,O., Reverdiau,P. and Courty,Y.
    Growth and survival of lung cancer cells: regulation by kallikrein-related peptidase 6 via activation of proteinase-activated receptor 2 and the epidermal growth factor receptor
    Biol Chem (2014) 395, 1015-1025. PubMed  Europe PubMed DOI
  38. Miners,J., Renfrew,R., Swirski,M. and Love,S.
    Accumulation of alpha-synuclein in dementia with Lewy bodies is associated with decline in the alpha-synuclein-degrading enzymes kallikrein-6 and calpain-1
    Acta Neuropathol Commun (2014) 2, 164-164. PubMed  Europe PubMed DOI
  39. Ott,C., Ainciburu,M., Parent,C., Michel,S., Roesch,C., Vourc'h,P., Corcia,P., Heuze-Vourc'h,N., Jolivet-Reynaud,C. and Courty,Y.
    Development of monoclonal antibodies to human kallikrein-related peptidase 6 (KLK6) and their use in an immunofluorometric assay for free KLK6
    Biol Chem (2014) 395, 1119-1126. PubMed  Europe PubMed DOI
  40. Ximerakis,M., Pampalakis,G., Roumeliotis,T.I., Sykioti,V.S., Garbis,S.D., Stefanis,L., Sotiropoulou,G. and Vekrellis,K.
    Resistance of naturally secreted alpha-synuclein to proteolysis
    FASEB J (2014) 28, 3146-3158. PubMed  Europe PubMed DOI
  41. Zhang,Y., Zhang,Z., Yang,L., Xu,B., Li,W., Tang,P., Zhang,Z., Han,N., Gao,Y., Cheng,S. and Xiao,T.
    Identification of human tissue kallikrein 6 as a potential marker of laryngeal cancer based on the relevant secretory/releasing protein database
    Dis Markers (2014) 2014, 594093-594093. PubMed  Europe PubMed DOI  PMC  EPMC
    42. 2013
  42. Burda,J.E., Radulovic,M., Yoon,H. and Scarisbrick,I.A.
    Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy
    Glia (2013) 61, 1456-1470. PubMed  Europe PubMed DOI
  43. Lose,F., Batra,J., O'Mara,T., Fahey,P., Marquart,L., Eeles,R.A., Easton,D.F., Al Olama,A.A., Kote-Jarai,Z., Guy,M., Muir,K., Lophatananon,A., Rahman,A.A., Neal,D.E., Hamdy,F.C., Donovan,J.L., Chambers,S., Gardiner,R.A., Aitken,J.F., Yaxley,J., Alexander,K., Clements,J.A., Spurdle,A.B. and Kedda,M.A.
    Common variation in kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness
    Urol Oncol (2013) 31, 635-643. PubMed  Europe PubMed DOI  M
  44. Lundwall,A.
    Old genes and new genes: The evolution of the kallikrein locus
    Thromb Haemost (2013) 110, 469-475. PubMed  Europe PubMed DOI  V
  45. Spencer,B., Michael,S., Shen,J., Kosberg,K., Rockenstein,E., Patrick,C., Adame,A. and Masliah,E.
    Lentivirus mediated delivery of neurosin promotes clearance of wild-type alpha-synuclein and reduces the pathology in an alpha-synuclein model of LBD
    Mol Ther (2013) 21, 31-41. PubMed  Europe PubMed DOI  U
  46. Yoon,H., Radulovic,M., Wu,J., Blaber,S.I., Blaber,M., Fehlings,M.G. and Scarisbrick,I.A.
    Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity
    J Neurochem (2013) 127, 283-298. PubMed  Europe PubMed DOI
    47. 2012
  47. Arnold,S., Pampalakis,G., Kantiotou,K., Silva,D., Cortez,C., Missailidis,S. and Sotiropoulou,G.
    One round of SELEX for the generation of DNA aptamers directed against KLK6
    Biol Chem (2012) 393, 343-353. PubMed  Europe PubMed DOI  I
  48. Bayani,J. and Diamandis,E.P.
    The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6)
    Clin Chem Lab Med (2012) 50, 211-233. PubMed  Europe PubMed DOI  V
  49. Clements,J.A., Hooper,J.D. and Dong,Y.
    The human tissue kallikrein and kallikrein-related peptidase family
    [ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
  50. Liang,G., Chen,X., Aldous,S., Pu,S.F., Mehdi,S., Powers,E., Giovanni,A., Kongsamut,S., Xia,T., Zhang,Y., Wang,R., Gao,Z., Merriman,G., McLean,L.R. and Morize,I.
    Virtual screening and X-ray crystallography for human kallikrein 6 inhibitors with an amidinothiophene P1 group
    ACS Med Chem Lett (2012) 3, 159-164. PubMed  Europe PubMed DOI  S  I
  51. Liang,G., Chen,X., Aldous,S., Pu,S.F., Mehdi,S., Powers,E., Xia,T. and Wang,R.
    Human kallikrein 6 inhibitors with a para-amidobenzylanmine P1 group identified through virtual screening
    Bioorg Med Chem Lett (2012) 22, 2450-2455. PubMed  Europe PubMed DOI  S  I
  52. Scarisbrick,I.A., Radulovic,M., Burda,J.E., Larson,N., Blaber,S.I., Giannini,C., Blaber,M. and Vandell,A.G.
    Kallikrein 6 is a novel molecular trigger of reactive astrogliosis
    Biol Chem (2012) 393, 355-367. PubMed  Europe PubMed DOI  PMC  EPMC
  53. Scarisbrick,I.A. and Blaber,M.
    Kallikrein-related peptidase 6
    [ISSN:978-0-12-407742-3] (2012) 3, 2778-2788. DOI
  54. Scarisbrick,I.A., Yoon,H., Panos,M., Larson,N., Blaber,S.I., Blaber,M. and Rodriguez,M.
    Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis
    Brain Pathol (2012) 22, 709-722. PubMed  Europe PubMed DOI
  55. Watanabe,Y. and Tanaka,M.
    Physiological functions and pathology of neurosin/kallikrein 6 in the central nervous system
    Proteomics Res J (2012) 3, 287-295.
    56. 2011
  56. Scarisbrick,I.A., Epstein,B., Cloud,B.A., Yoon,H., Wu,J., Renner,D.N., Blaber,S.I., Blaber,M., Vandell,A.G. and Bryson,A.L.
    Functional role of kallikrein 6 in regulating immune cell survival
    PLoS ONE (2011) 6, e18376-e18376. PubMed  Europe PubMed DOI  PMC  EPMC
    57. 2010
  57. Angelopoulou,K. and Karagiannis,G.S.
    Structural characterization and expression of five novel canine kallikrein-related peptidases in mammary cancer
    Mamm Genome (2010) 21, 516-524. PubMed  Europe PubMed DOI
  58. Ashby,E.L., Kehoe,P.G. and Love,S.
    Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia
    Brain Res (2010) 1363, 1-10. PubMed  Europe PubMed DOI
  59. Tatebe,H., Watanabe,Y., Kasai,T., Mizuno,T., Nakagawa,M., Tanaka,M. and Tokuda,T.
    Extracellular neurosin degrades alpha-synuclein in cultured cells
    Neurosci Res (2010) 67, 341-346. PubMed  Europe PubMed DOI
    60. 2009
  60. Pampalakis,G., Prosnikli,E., Agalioti,T., Vlahou,A., Zoumpourlis,V. and Sotiropoulou,G.
    A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition
    Cancer Res (2009) 69, 3779-3787. PubMed  Europe PubMed DOI
    61. 2008
  61. Clements,J.A.
    Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades?
    Biol Chem (2008) 389, 1447-1454. PubMed  Europe PubMed DOI  V
  62. Debela,M., Beaufort,N., Magdolen,V., Schechter,N.M., Craik,C.S., Schmitt,M., Bode,W. and Goettig,P.
    Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7
    Biol Chem (2008) 389, 623-632. PubMed  Europe PubMed DOI  P  S
  63. Kasai,T., Tokuda,T., Yamaguchi,N., Watanabe,Y., Kametani,F., Nakagawa,M. and Mizuno,T.
    Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro
    Neurosci Lett (2008) 436, 52-56. PubMed  Europe PubMed DOI  P
  64. Kountourakis,P., Psyrri,A., Scorilas,A., Camp,R., Markakis,S., Kowalski,D., Diamandis,E.P. and Dimopoulos,M.A.
    Prognostic value of kallikrein-related peptidase 6 protein expression levels in advanced ovarian cancer evaluated by automated quantitative analysis (AQUA)
    Cancer Sci (2008) 99, 2224-2229. PubMed  Europe PubMed DOI
  65. Li,H.X., Hwang,B.Y., Laxmikanthan,G., Blaber,S.I., Blaber,M., Golubkov,P.A., Ren,P., Iverson,B.L. and Georgiou,G.
    Substrate specificity of human kallikreins 1 and 6 determined by phage display
    Protein Sci (2008) 17, 664-672. PubMed  Europe PubMed DOI  PMC  EPMC  P
  66. Oikonomopoulou,K., Hansen,K.K., Baruch,A., Hollenberg,M.D. and Diamandis,E.P.
    Immunofluorometric activity-based probe analysis of active KLK6 in biological fluids
    Biol Chem (2008) 389, 747-756. PubMed  Europe PubMed DOI
  67. Pampalakis,G., Arampatzidou,M., Amoutzias,G., Kossida,S. and Sotiropoulou,G.
    Identification and analysis of mammalian KLK6 orthologue genes for prediction of physiological substrates
    Comput Biol Chem (2008) 32, 111-121. PubMed  Europe PubMed DOI
  68. Sharma,N., Oikonomopoulou,K., Ito,K., Renaux,B., Diamandis,E.P., Hollenberg,M.D. and Rancourt,D.E.
    Substrate specificity determination of mouse implantation serine proteinase and human kallikrein-related peptidase 6 by phage display
    Biol Chem (2008) 389, 1097-1105. PubMed  Europe PubMed DOI  P
  69. Wang,Y., Luo,W. and Reiser,G.
    Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions
    Cell Mol Life Sci (2008) 65, 237-252. PubMed  Europe PubMed DOI  V
  70. Yoon,H., Blaber,S.I., Evans,D.M., Trim,J., Juliano,M.A., Scarisbrick,I.A. and Blaber,M.
    Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis
    Protein Sci (2008) 17, 1998-2007. PubMed  Europe PubMed DOI  PMC  EPMC
    71. 2007
  71. Blaber,S.I., Yoon,H., Scarisbrick,I.A., Juliano,M.A. and Blaber,M.
    The autolytic regulation of human kallikrein-related peptidase 6
    Biochemistry (2007) 46, 5209-5217. PubMed  Europe PubMed DOI  PMC  EPMC
  72. Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U.
    Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis
    Genomics (2007) 89, 429-438. PubMed  Europe PubMed DOI
  73. Klucky,B., Mueller,R., Vogt,I., Teurich,S., Hartenstein,B., Breuhahn,K., Flechtenmacher,C., Angel,P. and Hess,J.
    Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion
    Cancer Res (2007) 67, 8198-8206. PubMed  Europe PubMed DOI
  74. Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M.
    Activation profiles and regulatory cascades of the human kallikrein-related peptidases
    J Biol Chem (2007) 282, 31852-31864. PubMed  Europe PubMed DOI  V
    75. 2006
  75. Angelo,P.F., Lima,A.R., Alves,F.M., Blaber,S.I., Scarisbrick,I.A., Blaber,M., Juliano,L. and Juliano,M.A.
    Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects
    J Biol Chem (2006) 281, 3116-3126. PubMed  Europe PubMed DOI  P
  76. [YEAR:25-9-2006]Bando,Y., Ito,S., Nagai,Y., Terayama,R., Kishibe,M., Jiang,Y.P., Mitrovic,B., Takahashi,T. and Yoshida,S.
    Implications of protease M/neurosin in myelination during experimental demyelination and remyelination
    Neurosci Lett (25-9-2006) 405, 175-180. PubMed  Europe PubMed DOI
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