Literature for peptidase S01.236: kallikrein-related peptidase 6

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Zingkou,E., Bisyris,E., Pampalakis,G. and Sotiropoulou,G. Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing J Pathol (2026) PubMed Europe PubMed DOI

2025

O'Neill,K.L., Zigmond,J.W. and Bergan,R. HSP90alpha and KLK6 Co-Regulate Stress-Induced Prostate Cancer Cell Motility bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC K L

2024

Boumali,R., Urli,L., Naim,M., Soualmia,F., Kinugawa,K., Petropoulos,I. and El Amri,C. Kallikrein-related peptidase's significance in Alzheimer's disease pathogenesis: A comprehensive survey Biochimie (2024) 226, 77-90. PubMed Europe PubMed DOI
Finnerty,R.M., Carulli,E.M., Bernhardt,M.L., Maddison,L.A. and Winuthayanon,W. Deletion of Kallikrein-related peptidases ( Klks ) has no effect on fertility in mice MicroPubl Biol (2024) 2024 PubMed Europe PubMed DOI PMC EPMC

2023

Sananes,A., Cohen,I., Allon,I., Ben-David,O., Abu Shareb,R., Yegodayev,K.M., Stepensky,D., Elkabets,M. and Papo,N. Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers Mol Oncol (2023) 17, 2337-2355. PubMed Europe PubMed DOI PMC EPMC
Stuardo-Parada,A., Lopez-Munoz,R., Villarroel-Espindola,F., Figueroa,C.D. and Ehrenfeld,P. Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung cancer Med Oncol (2023) 40, 224-224. PubMed Europe PubMed DOI V

2022

Baumann,A., Isak,D., Lohbeck,J., Jagtap,P.K.A., Hennig,J. and Miller,A.K. Scalable synthesis and structural characterization of reversible KLK6 inhibitors RSC Adv (2022) 12, 26989-26993. PubMed Europe PubMed DOI PMC EPMC
Bouzid,H., Soualmia,F., Oikonomopoulou,K., Soosaipillai,A., Walker,F., Louati,K., Lo Dico,R., Pocard,M., El Amri,C., Ignatenko,N.A. and Darmoul,D. Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer Peritoneal Metastasis Biomolecules (2022) 12 PubMed Europe PubMed DOI PMC EPMC
Zhang,L., Lovell,S., De Vita,E., Jagtap,P.K.A., Lucy,D., Goya Grocin,A., Kjaer,S., Borg,A., Hennig,J., Miller,A.K. and Tate,E.W. A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion J Am Chem Soc (2022) 144, 22493-22504. PubMed Europe PubMed DOI PMC EPMC
Zhao,K., Gao,M. and Lin,M. KLK6 Functions as an Oncogene and Unfavorable Prognostic Factor in Bladder Urothelial Carcinoma Dis Markers (2022) 2022, 3373851-3373851. PubMed Europe PubMed DOI PMC EPMC

2021

Ait Amiri,S., Deboux,C., Soualmia,F., Chaaya,N., Louet,M., Duplus,E., Betuing,S., Nait Oumesmar,B., Masurier,N. and El Amri,C. Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation J Med Chem (2021) 64, 5667-5688. PubMed Europe PubMed DOI
Ge,Y., Zhou,C., Xiao,X., Jin,Z., Zhou,L., Chen,Z., Liu,F., Yuan,Q., Zhang,G., Shan,L. and Tong,P. A Novel Mutation of the KLK6 Gene in a Family With Knee Osteoarthritis Front Genet (2021) 12, 784176-784176. PubMed Europe PubMed DOI PMC EPMC
Zani,M.B., Sant'Ana,A.M., Tognato,R.C., Chagas,J.R. and Puzer,L. Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases Front Med (Lausanne) (2021) 8, 777619-777619. PubMed Europe PubMed DOI PMC EPMC V

2020

Billi,A.C., Ludwig,J.E., Fritz,Y., Rozic,R., Swindell,W.R., Tsoi,L.C., Gruzska,D., Abdollahi-Roodsaz,S., Xing,X., Diaconu,D., Uppala,R., Camhi,M.I., Klenotic,P.A., Sarkar,M.K., Husni,M.E., Scher,J.U., McDonald,C., Kahlenberg,J.M., Midura,R.J., Gudjonsson,J.E. and Ward,N.L. KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease J Clin Invest (2020) 130, 3151-3157. PubMed Europe PubMed DOI
Clarke,J. Proteinase KLK6 links skin and joint inflammation in PsA Nat Rev Rheumatol (2020) 16, 250-250. PubMed Europe PubMed DOI
De Vita,E., Smits,N., van den Hurk,H., Beck,E.M., Hewitt,J., Baillie,G., Russell,E., Pannifer,A., Hamon,V., Morrison,A., McElroy,S.P., Jones,P., Ignatenko,N.A., Gunkel,N. and Miller,A.K. Synthesis and structure-activity relationships of N-(4-benzamidino)-oxazolidinones: potent and selective inhibitors of kallikrein-related peptidase 6 ChemMedChem (2020) 15, 79-95. PubMed Europe PubMed DOI I
Mella,C., Figueroa,C.D., Otth,C. and Ehrenfeld,P. Involvement of Kallikrein-Related Peptidases in Nervous System Disorders Front Cell Neurosci (2020) 14, 166-166. PubMed Europe PubMed DOI PMC EPMC V
Tommasi,C., Rogerson,C., Depledge,D.P., Jones,M., Naeem,A.S., Venturini,C., Frampton,D., Tutill,H.J., Way,B., Breuer,J. and O'Shaughnessy,R.F.L. Kallikrein-mediated cytokeratin 10 degradation is required for varicella zoster virus propagation in skin J Invest Dermatol (2020) 140, 774-784. PubMed Europe PubMed DOI

2019

Chen,H., Sells,E., Pandey,R., Abril,E.R., Hsu,C.H., Krouse,R.S., Nagle,R.B., Pampalakis,G., Sotiropoulou,G. and Ignatenko,N.A. Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein Oncotarget (2019) 10, 6062-6078. PubMed Europe PubMed DOI PMC EPMC
Pampalakis,G., Zingkou,E., Sidiropoulos,K.G., Diamandis,E.P., Zoumpourlis,V., Yousef,G.M. and Sotiropoulou,G. Biochemical pathways mediated by KLK6 protease in breast cancer Mol Oncol (2019) 13, 2329-2343. PubMed Europe PubMed DOI
Zingkou,E., Pampalakis,G., Charla,E., Nauroy,P., Kiritsi,D. and Sotiropoulou,G. A proinflammatory role of KLK6 protease in Netherton syndrome J Dermatol Sci (2019) 95, 28-35. PubMed Europe PubMed DOI

2018

Andrejc,D. and Legisa,M. Kallikrein-related peptidase 6 can cleave human-muscle-type 6-phosphofructo-1-kinase into highly active shorter fragments Biochim Biophys Acta (2018) 1866, 602-607. PubMed Europe PubMed DOI
De Vita,E., Schuler,P., Lovell,S., Lohbeck,J., Kullmann,S., Rabinovich,E., Sananes,A., Hessling,B., Hamon,V., Papo,N., Hess,J., Tate,E.W., Gunkel,N. and Miller,A.K. Depsipeptides featuring a neutral P1 are potent inhibitors of kallikrein-related peptidase 6 with on-target cellular activity J Med Chem (2018) 61, 8859-8874. PubMed Europe PubMed DOI I
Khoury,N., Zingkou,E., Pampalakis,G., Sofopoulos,M., Zoumpourlis,V. and Sotiropoulou,G. KLK6 protease accelerates skin tumor formation and progression Carcinogenesis (2018) 39, 1529-1536. PubMed Europe PubMed DOI K
Loessner,D., Goettig,P., Preis,S., Felber,J., Bronger,H., Clements,J.A., Dorn,J. and Magdolen,V. Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer Expert Opin Ther Targets (2018) 22, 745-763. PubMed Europe PubMed DOI T
Sananes,A., Cohen,I., Shahar,A., Hockla,A., De Vita,E., Miller,A.K., Radisky,E.S. and Papo,N. A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering J Biol Chem (2018) 293, 12663-12680. PubMed Europe PubMed DOI S
Soualmia,F., Bosc,E., Amiri,S.A., Stratmann,D., Magdolen,V., Darmoul,D., Reboud-Ravaux,M. and El Amri,C. Insights into the activity control of the kallikrein-related peptidase 6: small-molecule modulators and allosterism Biol Chem (2018) 399, 1073-1078. PubMed Europe PubMed DOI I
Yoon,H., Radulovic,M. and Scarisbrick,I.A. Kallikrein-related peptidase 6 orchestrates astrocyte form and function through proteinase activated receptor-dependent mechanisms Biol Chem (2018) 399, 1041-1052. PubMed Europe PubMed DOI

2017

Adamopoulos,P.G., Kontos,C.K. and Scorilas,A. Molecular cloning of novel transcripts of human kallikrein-related peptidases 5, 6, 7, 8 and 9 (KLK5 - KLK9), using Next-generation sequencing Sci Rep (2017) 7, 17299-17299. PubMed Europe PubMed DOI PMC EPMC M
Iinuma,S., Kishibe,M., Saito,N., Igawa,S., Honma,M., Bando,Y., Yoshida,S. and Ishida-Yamamoto,A. Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through a protease-activated receptor 2-independent mechanism Exp Dermatol (2017) 26, 289-291. PubMed Europe PubMed DOI
Pampalakis,G., Sykioti,V.-S., Ximerakis,M., Stefanakou-Kalakou,I., Melki,R., Vekrellis,K. and Sotiropoulou,G. KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species Oncotarget (2017) 8, 14502-14515. PubMed Europe PubMed DOI
Silva,R.N., Oliveira,L.C., Parise,C.B., Oliveira,J.R., Severino,B., Corvino,A., di Vaio,P., Temussi,P.A., Caliendo,G., Santagada,V., Juliano,L. and Juliano,M.A. Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease? Biochim Biophys Acta (2017) 1865, 558-564. PubMed Europe PubMed DOI P

2016

Karakosta,T.D., Soosaipillai,A., Diamandis,E.P., Batruch,I. and Drabovich,A.P. Quantification of human kallikrein-related peptidases in biological fluids by multiplatform targeted mass spectrometry assays Mol Cell Proteomics (2016) 15, 2863-2876. PubMed Europe PubMed DOI A
Kishibe,M., Baida,G., Bhalla,P., Lavker,R.M., Schlosser,B., Iinuma,S., Yoshida,S., Dudley,J.T. and Budunova,I. Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids Oncotarget (2016) 7, 69479-69488. PubMed Europe PubMed DOI K

2015

Spencer,B., Valera,E., Rockenstein,E., Trejo-Morales,M., Adame,A. and Masliah,E. A brain-targeted, modified neurosin (kallikrein-6) reduces alpha-synuclein accumulation in a mouse model of multiple system atrophy Mol Neurodegener (2015) 10, 48-48. PubMed Europe PubMed DOI PMC EPMC U
Yu,Y., Li,H., Zhang,B., Pan,X., Zhu,X., Ding,Y. and Li,G. Peptide network for detection of tissue-remodeling enzyme in the prognosis of hepatocellular carcinoma ACS Appl Mater Interfaces (2015) 7, 4401-4405. PubMed Europe PubMed DOI A

2014

Michel,N., Heuze-Vourc'h,N., Lavergne,E., Parent,C., Jourdan,M.L., Vallet,A., Iochmann,S., Musso,O., Reverdiau,P. and Courty,Y. Growth and survival of lung cancer cells: regulation by kallikrein-related peptidase 6 via activation of proteinase-activated receptor 2 and the epidermal growth factor receptor Biol Chem (2014) 395, 1015-1025. PubMed Europe PubMed DOI
Miners,J., Renfrew,R., Swirski,M. and Love,S. Accumulation of alpha-synuclein in dementia with Lewy bodies is associated with decline in the alpha-synuclein-degrading enzymes kallikrein-6 and calpain-1 Acta Neuropathol Commun (2014) 2, 164-164. PubMed Europe PubMed DOI
Ott,C., Ainciburu,M., Parent,C., Michel,S., Roesch,C., Vourc'h,P., Corcia,P., Heuze-Vourc'h,N., Jolivet-Reynaud,C. and Courty,Y. Development of monoclonal antibodies to human kallikrein-related peptidase 6 (KLK6) and their use in an immunofluorometric assay for free KLK6 Biol Chem (2014) 395, 1119-1126. PubMed Europe PubMed DOI
Ximerakis,M., Pampalakis,G., Roumeliotis,T.I., Sykioti,V.S., Garbis,S.D., Stefanis,L., Sotiropoulou,G. and Vekrellis,K. Resistance of naturally secreted alpha-synuclein to proteolysis FASEB J (2014) 28, 3146-3158. PubMed Europe PubMed DOI
Zhang,Y., Zhang,Z., Yang,L., Xu,B., Li,W., Tang,P., Zhang,Z., Han,N., Gao,Y., Cheng,S. and Xiao,T. Identification of human tissue kallikrein 6 as a potential marker of laryngeal cancer based on the relevant secretory/releasing protein database Dis Markers (2014) 2014, 594093-594093. PubMed Europe PubMed DOI PMC EPMC

2013

Burda,J.E., Radulovic,M., Yoon,H. and Scarisbrick,I.A. Critical role for PAR1 in kallikrein 6-mediated oligodendrogliopathy Glia (2013) 61, 1456-1470. PubMed Europe PubMed DOI
Lose,F., Batra,J., O'Mara,T., Fahey,P., Marquart,L., Eeles,R.A., Easton,D.F., Al Olama,A.A., Kote-Jarai,Z., Guy,M., Muir,K., Lophatananon,A., Rahman,A.A., Neal,D.E., Hamdy,F.C., Donovan,J.L., Chambers,S., Gardiner,R.A., Aitken,J.F., Yaxley,J., Alexander,K., Clements,J.A., Spurdle,A.B. and Kedda,M.A. Common variation in kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness Urol Oncol (2013) 31, 635-643. PubMed Europe PubMed DOI M
Lundwall,A. Old genes and new genes: The evolution of the kallikrein locus Thromb Haemost (2013) 110, 469-475. PubMed Europe PubMed DOI V
Spencer,B., Michael,S., Shen,J., Kosberg,K., Rockenstein,E., Patrick,C., Adame,A. and Masliah,E. Lentivirus mediated delivery of neurosin promotes clearance of wild-type alpha-synuclein and reduces the pathology in an alpha-synuclein model of LBD Mol Ther (2013) 21, 31-41. PubMed Europe PubMed DOI U
Yoon,H., Radulovic,M., Wu,J., Blaber,S.I., Blaber,M., Fehlings,M.G. and Scarisbrick,I.A. Kallikrein 6 signals through PAR1 and PAR2 to promote neuron injury and exacerbate glutamate neurotoxicity J Neurochem (2013) 127, 283-298. PubMed Europe PubMed DOI

2012

Arnold,S., Pampalakis,G., Kantiotou,K., Silva,D., Cortez,C., Missailidis,S. and Sotiropoulou,G. One round of SELEX for the generation of DNA aptamers directed against KLK6 Biol Chem (2012) 393, 343-353. PubMed Europe PubMed DOI I
Bayani,J. and Diamandis,E.P. The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6) Clin Chem Lab Med (2012) 50, 211-233. PubMed Europe PubMed DOI V
Clements,J.A., Hooper,J.D. and Dong,Y. The human tissue kallikrein and kallikrein-related peptidase family [ISSN:978-0-12-407742-3] (2012) 3, 2747-2756. DOI
Liang,G., Chen,X., Aldous,S., Pu,S.F., Mehdi,S., Powers,E., Giovanni,A., Kongsamut,S., Xia,T., Zhang,Y., Wang,R., Gao,Z., Merriman,G., McLean,L.R. and Morize,I. Virtual screening and X-ray crystallography for human kallikrein 6 inhibitors with an amidinothiophene P1 group ACS Med Chem Lett (2012) 3, 159-164. PubMed Europe PubMed DOI S I
Liang,G., Chen,X., Aldous,S., Pu,S.F., Mehdi,S., Powers,E., Xia,T. and Wang,R. Human kallikrein 6 inhibitors with a para-amidobenzylanmine P1 group identified through virtual screening Bioorg Med Chem Lett (2012) 22, 2450-2455. PubMed Europe PubMed DOI S I
Scarisbrick,I.A., Radulovic,M., Burda,J.E., Larson,N., Blaber,S.I., Giannini,C., Blaber,M. and Vandell,A.G. Kallikrein 6 is a novel molecular trigger of reactive astrogliosis Biol Chem (2012) 393, 355-367. PubMed Europe PubMed DOI PMC EPMC
Scarisbrick,I.A. and Blaber,M. Kallikrein-related peptidase 6 [ISSN:978-0-12-407742-3] (2012) 3, 2778-2788. DOI
Scarisbrick,I.A., Yoon,H., Panos,M., Larson,N., Blaber,S.I., Blaber,M. and Rodriguez,M. Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis Brain Pathol (2012) 22, 709-722. PubMed Europe PubMed DOI
Watanabe,Y. and Tanaka,M. Physiological functions and pathology of neurosin/kallikrein 6 in the central nervous system Proteomics Res J (2012) 3, 287-295.

2011

Scarisbrick,I.A., Epstein,B., Cloud,B.A., Yoon,H., Wu,J., Renner,D.N., Blaber,S.I., Blaber,M., Vandell,A.G. and Bryson,A.L. Functional role of kallikrein 6 in regulating immune cell survival PLoS ONE (2011) 6, e18376-e18376. PubMed Europe PubMed DOI PMC EPMC

2010

Angelopoulou,K. and Karagiannis,G.S. Structural characterization and expression of five novel canine kallikrein-related peptidases in mammary cancer Mamm Genome (2010) 21, 516-524. PubMed Europe PubMed DOI
Ashby,E.L., Kehoe,P.G. and Love,S. Kallikrein-related peptidase 6 in Alzheimer's disease and vascular dementia Brain Res (2010) 1363, 1-10. PubMed Europe PubMed DOI
Tatebe,H., Watanabe,Y., Kasai,T., Mizuno,T., Nakagawa,M., Tanaka,M. and Tokuda,T. Extracellular neurosin degrades alpha-synuclein in cultured cells Neurosci Res (2010) 67, 341-346. PubMed Europe PubMed DOI

2009

Pampalakis,G., Prosnikli,E., Agalioti,T., Vlahou,A., Zoumpourlis,V. and Sotiropoulou,G. A tumor-protective role for human kallikrein-related peptidase 6 in breast cancer mediated by inhibition of epithelial-to-mesenchymal transition Cancer Res (2009) 69, 3779-3787. PubMed Europe PubMed DOI

2008

Clements,J.A. Reflections on the tissue kallikrein and kallikrein-related peptidase family - from mice to men - what have we learnt in the last two decades? Biol Chem (2008) 389, 1447-1454. PubMed Europe PubMed DOI V
Debela,M., Beaufort,N., Magdolen,V., Schechter,N.M., Craik,C.S., Schmitt,M., Bode,W. and Goettig,P. Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7 Biol Chem (2008) 389, 623-632. PubMed Europe PubMed DOI P S
Kasai,T., Tokuda,T., Yamaguchi,N., Watanabe,Y., Kametani,F., Nakagawa,M. and Mizuno,T. Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro Neurosci Lett (2008) 436, 52-56. PubMed Europe PubMed DOI P
Kountourakis,P., Psyrri,A., Scorilas,A., Camp,R., Markakis,S., Kowalski,D., Diamandis,E.P. and Dimopoulos,M.A. Prognostic value of kallikrein-related peptidase 6 protein expression levels in advanced ovarian cancer evaluated by automated quantitative analysis (AQUA) Cancer Sci (2008) 99, 2224-2229. PubMed Europe PubMed DOI
Li,H.X., Hwang,B.Y., Laxmikanthan,G., Blaber,S.I., Blaber,M., Golubkov,P.A., Ren,P., Iverson,B.L. and Georgiou,G. Substrate specificity of human kallikreins 1 and 6 determined by phage display Protein Sci (2008) 17, 664-672. PubMed Europe PubMed DOI PMC EPMC P
Oikonomopoulou,K., Hansen,K.K., Baruch,A., Hollenberg,M.D. and Diamandis,E.P. Immunofluorometric activity-based probe analysis of active KLK6 in biological fluids Biol Chem (2008) 389, 747-756. PubMed Europe PubMed DOI
Pampalakis,G., Arampatzidou,M., Amoutzias,G., Kossida,S. and Sotiropoulou,G. Identification and analysis of mammalian KLK6 orthologue genes for prediction of physiological substrates Comput Biol Chem (2008) 32, 111-121. PubMed Europe PubMed DOI
Sharma,N., Oikonomopoulou,K., Ito,K., Renaux,B., Diamandis,E.P., Hollenberg,M.D. and Rancourt,D.E. Substrate specificity determination of mouse implantation serine proteinase and human kallikrein-related peptidase 6 by phage display Biol Chem (2008) 389, 1097-1105. PubMed Europe PubMed DOI P
Wang,Y., Luo,W. and Reiser,G. Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions Cell Mol Life Sci (2008) 65, 237-252. PubMed Europe PubMed DOI V
Yoon,H., Blaber,S.I., Evans,D.M., Trim,J., Juliano,M.A., Scarisbrick,I.A. and Blaber,M. Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis Protein Sci (2008) 17, 1998-2007. PubMed Europe PubMed DOI PMC EPMC

2007

Blaber,S.I., Yoon,H., Scarisbrick,I.A., Juliano,M.A. and Blaber,M. The autolytic regulation of human kallikrein-related peptidase 6 Biochemistry (2007) 46, 5209-5217. PubMed Europe PubMed DOI PMC EPMC
Fernando,S.C., Najar,F.Z., Guo,X., Zhou,L., Fu,Y., Geisert,R.D., Roe,B.A. and DeSilva,U. Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis Genomics (2007) 89, 429-438. PubMed Europe PubMed DOI
Klucky,B., Mueller,R., Vogt,I., Teurich,S., Hartenstein,B., Breuhahn,K., Flechtenmacher,C., Angel,P. and Hess,J. Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion Cancer Res (2007) 67, 8198-8206. PubMed Europe PubMed DOI
Yoon,H., Laxmikanthan,G., Lee,J., Blaber,S.I., Rodriguez,A., Kogot,J.M., Scarisbrick,I.A. and Blaber,M. Activation profiles and regulatory cascades of the human kallikrein-related peptidases J Biol Chem (2007) 282, 31852-31864. PubMed Europe PubMed DOI V

2006

Angelo,P.F., Lima,A.R., Alves,F.M., Blaber,S.I., Scarisbrick,I.A., Blaber,M., Juliano,L. and Juliano,M.A. Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects J Biol Chem (2006) 281, 3116-3126. PubMed Europe PubMed DOI P
[YEAR:25-9-2006]Bando,Y., Ito,S., Nagai,Y., Terayama,R., Kishibe,M., Jiang,Y.P., Mitrovic,B., Takahashi,T. and Yoshida,S. Implications of protease M/neurosin in myelination during experimental demyelination and remyelination Neurosci Lett (25-9-2006) 405, 175-180. PubMed Europe PubMed DOI
[YEAR:14-11-2006]Darling,M.R., Jackson-Boeters,L., Daley,T.D. and Diamandis,E.P. Human kallikrein 6 expression in salivary gland tumors J Histochem Cytochem (14-11-2006) 54, 337-342. PubMed Europe PubMed DOI
[YEAR:1-6-2006]Debela,M., Magdolen,V., Schechter,N., Valachova,M., Lottspeich,F., Craik,C.S., Choe,Y., Bode,W. and Goettig,P. Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences J Biol Chem (1-6-2006) 281, 25678-25688. PubMed Europe PubMed DOI P
Heuze-Vourc'h,N., Ainciburu,M., Planque,C., Brillard-Bourdet,M., Ott,C., Jolivet-Reynaud,C. and Courty,Y. Recombinant kallikrein expression: site-specific integration for hK6 production in human cells Biol Chem (2006) 387, 687-695. PubMed Europe PubMed DOI E
Pampalakis,G. and Sotiropoulou,G. Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer Biol Chem (2006) 387, 773-782. PubMed Europe PubMed DOI
Prezas,P., Arlt,M.J., Viktorov,P., Soosaipillai,A., Holzscheiter,L., Schmitt,M., Talieri,M., Diamandis,E.P., Kruger,A. and Magdolen,V. Overexpression of the human tissue kallikrein genes KLK4, 5, 6, and 7 increases the malignant phenotype of ovarian cancer cells Biol Chem (2006) 387, 807-811. PubMed Europe PubMed DOI
Scarisbrick,I.A., Sabharwal,P., Cruz,H., Larsen,N., Vandell,A.G., Blaber,S.I., Ameenuddin,S., Papke,L.M., Fehlings,M.G., Reeves,R.K., Blaber,M., Windebank,A.J. and Rodriguez,M. Dynamic role of kallikrein 6 in traumatic spinal cord injury Eur J Neurosci (2006) 24, 1457-1469. PubMed Europe PubMed DOI

2005

[YEAR:25-5-2005]Kurlender,L., Borgono,C., Michael,I.P., Obiezu,C., Elliott,M.B., Yousef,G.M. and Diamandis,E.P. A survey of alternative transcripts of human tissue kallikrein genes Biochim Biophys Acta (25-5-2005) 1755, 1-14. PubMed Europe PubMed DOI R
[YEAR:1-10-2005]Nagahara,H., Mimori,K., Utsunomiya,T., Barnard,G.F., Ohira,M., Hirakawa,K. and Mori,M. Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer Clin Cancer Res (1-10-2005) 11, 6800-6806. PubMed Europe PubMed DOI
[YEAR:15-4-2005]Ogawa,K., Utsunomiya,T., Mimori,K., Tanaka,F., Inoue,H., Nagahara,H., Murayama,S. and Mori,M. Clinical significance of human kallikrein gene 6 messenger RNA expression in colorectal cancer Clin Cancer Res (15-4-2005) 11, 2889-2893. PubMed Europe PubMed DOI
Oka,Y., Uchida,A., Aoyama,M., Fujita,M., Hotta,N., Tada,T., Katano,H., Mase,M., Asai,K. and Yamada,K. Expression of myelencephalon-specific protease after cryogenic lesioning of the rat parietal cortex J Neurotrauma (2005) 22, 501-510. PubMed Europe PubMed DOI
[YEAR:1-7-2005]Terayama,R., Bando,Y., Jiang,Y.P., Mitrovic,B. and Yoshida,S. Differential expression of protease M/neurosin in oligodendrocytes and their progenitors in an animal model of multiple sclerosis Neurosci Lett (1-7-2005) 382, 82-87. PubMed Europe PubMed DOI

2004

Bayes,A., Tsetsenis,T., Ventura,S., Vendrell,J., Aviles,F.X. and Sotiropoulou,G. Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation Biol Chem (2004) 385, 517-524. PubMed Europe PubMed DOI
Blaber,S.I., Ciric,B., Christophi,G.P., Bernett,M.J., Blaber,M., Rodriguez,M. and Scarisbrick,I.A. Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease FASEB J (2004) 18, 920-922. PubMed Europe PubMed DOI
Christophi,G.P., Isackson,P.J., Blaber,S., Blaber,M., Rodriguez,M. and Scarisbrick,I.A. Distinct promoters regulate tissue-specific and differential expression of kallikrein 6 in CNS demyelinating disease J Neurochem (2004) 91, 1439-1449. PubMed Europe PubMed DOI
Clements,J.A., Hooper,J.D., Odorico,D.M. and Dong,Y. The tissue kallikrein gene cluster [ISSN:0-12-079610-4] (2004) 2, 1569-1577. V
Ghosh,M.C., Grass,L., Soosaipillai,A., Sotiropoulou,G. and Diamandis,E.P. Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells Tumour Biol (2004) 25, 193-199. PubMed Europe PubMed DOI
[YEAR:16-8-2004]Ni,X., Zhang,W., Huang,K.C., Wang,Y., Ng,S.K., Mok,S.C., Berkowitz,R.S. and Ng,S.W. Characterisation of human kallikrein 6/protease M expression in ovarian cancer Br J Cancer (16-8-2004) 91, 725-731. PubMed Europe PubMed DOI PMC EPMC
[YEAR:16-7-2004]Pampalakis,G., Kurlender,L., Diamandis,E.P. and Sotiropoulou,G. Cloning and characterization of novel isoforms of the human kallikrein 6 gene Biochem Biophys Res Commun (16-7-2004) 320, 54-61. PubMed Europe PubMed DOI
Scarisbrick,I.A., Blaber,S.I. and Blaber,M. Myelencephalon-specific protease [ISSN:0-12-079610-4] (2004) 2, 1587-1591. V
Terayama,R., Bando,Y., Takahashi,T. and Yoshida,S. Differential expression of neuropsin and protease M/neurosin in oligodendrocytes after injury to the spinal cord Glia (2004) 48, 91-101. PubMed Europe PubMed DOI
[YEAR:26-7-2004]Uchida,A., Oka,Y., Aoyama,M., Suzuki,S., Yokoi,T., Katano,H., Mase,M., Tada,T., Asai,K. and Yamada,K. Expression of myelencephalon-specific protease in transient middle cerebral artery occlusion model of rat brain Brain Res Mol Brain Res (26-7-2004) 126, 129-136. PubMed Europe PubMed DOI
Yamaguchi,N. Neurosin or human kallikrein 6 [ISSN:0-12-079610-4] (2004) 2, 1585-1587. V
Yousef,G.M., Borgono,C.A., White,N.M., Robb,J.D., Michael,I.P., Oikonomopoulou,K., Khan,S. and Diamandis,E.P. In silico analysis of the human kallikrein gene 6 Tumour Biol (2004) 25, 282-289. PubMed Europe PubMed DOI

2003

[YEAR:15-3-2003]Diamandis,E.P., Scorilas,A., Fracchioli,S., Van Gramberen,M., De Bruijn,H., Henrik,A., Soosaipillai,A., Grass,L., Yousef,G.M., Stenman,U.H., Massobrio,M., Van Der Zee,A.G., Vergote,I. and Katsaros,D. Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma J Clin Oncol (15-3-2003) 21, 1035-1043. PubMed Europe PubMed DOI
Hutchinson,S., Luo,L.Y., Yousef,G.M., Soosaipillai,A. and Diamandis,E.P. Purification of human kallikrein 6 from biological fluids and identification of its complex with alpha(1)-antichymotrypsin Clin Chem (2003) 49, 746-751. PubMed Europe PubMed DOI
[YEAR:15-10-2003]Iwata,A., Maruyama,M., Akagi,T., Hashikawa,T., Kanazawa,I., Tsuji,S. and Nukina,N. Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies Hum Mol Genet (15-10-2003) 12, 2625-2635. PubMed Europe PubMed DOI
[YEAR:8-8-2003]Magklara,A., Mellati,A.A., Wasney,G.A., Little,S.P., Sotiropoulou,G., Becker,G.W. and Diamandis,E.P. Characterization of the enzymatic activity of human kallikrein 6: autoactivation, substrate specificity, and regulation by inhibitors Biochem Biophys Res Commun (8-8-2003) 307, 948-955. PubMed Europe PubMed DOI
[YEAR:1-5-2003]Yousef,G.M., Polymeris,M.E., Yacoub,G.M., Scorilas,A., Soosaipillai,A., Popalis,C., Fracchioli,S., Katsaros,D. and Diamandis,E.P. Parallel overexpression of seven kallikrein genes in ovarian cancer Cancer Res (1-5-2003) 63, 2223-2227. PubMed Europe PubMed

2002

[YEAR:5-7-2002]Bernett,M.J., Blaber,S.I., Scarisbrick,I.A., Dhanarajan,P., Thompson,S.M. and Blaber,M. Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system J Biol Chem (5-7-2002) 277, 24562-24570. PubMed Europe PubMed DOI S
[YEAR:29-1-2002]Blaber,S.I., Scarisbrick,I.A., Bernett,M.J., Dhanarajan,P., Seavy,M.A., Jin,Y., Schwartz,M.A., Rodriguez,M. and Blaber,M. Enzymatic properties of rat myelencephalon-specific protease Biochemistry (29-1-2002) 41, 1165-1173. PubMed Europe PubMed DOI
[YEAR:26-7-2002]Gomis-Ruth,F.X., Bayes,A., Sotiropoulou,G., Pampalakis,G., Tsetsenis,T., Villegas,V., Aviles,F.X. and Coll,M. The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family J Biol Chem (26-7-2002) 277, 27273-27281. PubMed Europe PubMed DOI S
Scarisbrick,I.A., Blaber,S.I., Lucchinetti,C.F., Genain,C.P., Blaber,M. and Rodriguez,M. Activity of a newly identified serine protease in CNS demyelination Brain (2002) 125, 1283-1296. PubMed Europe PubMed
[YEAR:26-4-2002]Yokoi,T., Yamamoto,N., Tada,T., Fujita,M., Moriyama,A., Matsui,H., Takahashi,T., Togari,H., Kato,T. and Asai,K. Developmental changes and localization of mouse brain serine proteinase mRNA and protein in mouse brain Neurosci Lett (26-4-2002) 323, 133-136. PubMed Europe PubMed DOI

2001

Breitenbach,U., Tuckermann,J.P., Gebhardt,C., Richter,K.H., rstenberger,G., Christofori,G. and Angel,P. Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis J Invest Dermatol (2001) 117, 634-640. PubMed Europe PubMed DOI
Clements,J., Hooper,J., Dong,Y. and Harvey,T. The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential functions Biol Chem (2001) 382, 5-14. PubMed Europe PubMed DOI V
[YEAR:25-5-2001]Okui,A., Kominami,K., Uemura,H., Mitsui,S. and Yamaguchi,N. Characterization of a brain-related serine protease, neurosin (human kaillikrein 6), in human cerebrospinal fluid Neuroreport (25-5-2001) 12, 1345-1350. PubMed Europe PubMed
Petraki,C.D., Karavana,V.N., Skoufogiannis,P.T., Little,S.P., Howarth,D.J., Yousef,G.M. and Diamandis,E.P. The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry J Histochem Cytochem (2001) 49, 1431-1441. PubMed Europe PubMed
[YEAR:12-3-2001]Scarisbrick,I.A., Isackson,P.J., Ciric,B., Windebank,A.J. and Rodriguez,M. MSP, a trypsin-like serine protease, is abundantly expressed in the human nervous system J Comp Neurol (12-3-2001) 431, 347-361. PubMed Europe PubMed DOI
Tanimoto,H., Underwood,L.J., Shigemasa,K., Parmley,T.H. and O'Brien,T.J. Increased expression of protease M in ovarian tumors Tumour Biol (2001) 22, 11-18. PubMed Europe PubMed

2000

Diamandis,E.P., Yousef,G.M., Petraki,C. and Soosaipillai,A.R. Human kallikrein 6 as a biomarker of Alzheimer's disease Clin Biochem (2000) 33, 663-667. PubMed Europe PubMed DOI
Diamandis,E.P., Yousef,G.M., Soosaipillai,A.R. and Bunting,P. Human kallikrein 6 (zyme/protease M/neurosin): A new serum biomarker of ovarian carcinoma Clin Biochem (2000) 33, 579-583. PubMed Europe PubMed DOI
Diamandis,E.P., Yousef,G.M., Luo,L.Y., Magklara,A. and Obiezu,C.V. The new human kallikrein gene family: implications in carcinogenesis Trends Endocrinol Metab (2000) 11, 54-60. PubMed Europe PubMed DOI
Diamandis,E.P., Yousef,G.M., Soosaipillai,A.R., Grass,L., Porter,A., Little,S. and Sotiropoulou,G. Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications Clin Biochem (2000) 33, 369-375. PubMed Europe PubMed DOI A
[YEAR:14-4-2000]Matsui,H., Kimura,A., Yamashiki,N., Moriyama,A., Kaya,M., Yoshida,I., Takagi,N. and Takahashi,T. Molecular and biochemical characterization of a serine proteinase predominantly expressed in the medulla oblongata and cerebellar white matter of mouse brain J Biol Chem (14-4-2000) 275, 11050-11057. PubMed Europe PubMed DOI
Ogawa,K., Yamada,T., Tsujioka,Y., Taguchi,J., Takahashi,M., Tsuboi,Y., Fujino,Y., Nakajima,M., Yamamoto,T., Akatsu,H., Mitsui,S. and Yamaguchi,N. Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease Psychiatry Clin Neurosci (2000) 54, 419-426. PubMed Europe PubMed DOI
Scarisbrick,I.A., Asakura,K., Blaber,S., Blaber,M., Isackson,P.J., Bieto,T., Rodriguez,M. and Windebank,A.J. Preferential expression of myelencephalon-specific protease by oligodendrocytes of the adult rat spinal cord white matter Glia (2000) 30, 219-230. PubMed Europe PubMed DOI

1999

[YEAR:10-5-1999]Meier,N., Dear,T.N. and Boehm,T. A novel serine protease overexpressed in the hair follicles of nude mice Biochem Biophys Res Commun (10-5-1999) 258, 374-378. PubMed Europe PubMed DOI
[YEAR:25-8-1999]Yamanaka,H., He,X., Matsumoto,K., Shiosaka,S. and Yoshida,S. Protease M/neurosin mRNA is expressed in mature oligodendrocytes Brain Res Mol Brain Res (25-8-1999) 71, 217-224. PubMed Europe PubMed DOI
[YEAR:1-12-1999]Yousef,G.M., Luo,L.Y., Scherer,S.W., Sotiropoulou,G. and Diamandis,E.P. Molecular characterization of zyme/protease M/neurosin (PRSS9), a hormonally regulated kallikrein-like serine protease Genomics (1-12-1999) 62, 251-259. PubMed Europe PubMed DOI

1997

Little,S.P., Dixon,E.P., Norris,F., Buckley,W., Becker,G.W., Johnson,M., Dobbins,J.R., Wyrick,T., Miller,J.R., MacKellar,W., Hepburn,D., Corvalan,J., McClure,D., Liu,X., Stephenson,D., Clemens,J. and Johnstone,E.M. Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain J Biol Chem (1997) 272, 25135-25142. PubMed Europe PubMed DOI
Scarisbrick,I.A., Towner,M.D. and Isackson,P.J. Nervous system-specific expression of a novel serine protease: Regulation in the adult rat spinal cord by excitotoxic injury J Neurosci (1997) 17, 8156-8168. PubMed Europe PubMed
Yamashiro,K., Tsuruoka,N., Kodama,S., Tsujimoto,M., Yamamura,Y., Tanaka,T., Nakazato,H. and Yamaguchi,N. Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain Biochim Biophys Acta (1997) 1350, 11-14. PubMed Europe PubMed DOI

1996

Anisowicz,A., Sotiropoulou,G., Stenman,G., Mok,S.C. and Sager,R. A novel protease homolog differentially expressed in breast and ovarian cancer Mol Med (1996) 2, 624-636. PubMed Europe PubMed PMC EPMC