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Literature for peptidase S01.231: urokinase-type plasminogen activator

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Bahi,A. and Steele,S.<br>Novel Roles for Urokinase- and Tissue-Type Plasminogen Activators in the Pathogenesis of Mood Disorders<br>Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC
  2. Chakraborty,R., Kannan,S.P., Afrose,N. and Narayanasamy,D.<br>Tumor microenvironment expressed enzymes (Matrix metalloproteinases, cathepsins, urokinase-type plasminogen activator) triggered polymersomes for liquid biopsy and cancer diagnostics: A review<br>Int J Biol Macromol (2025) 321, 146375-146375. PubMed  Europe PubMed DOI
  3. Hu,K., Wang,X., Dai,D., Shen,J., Zhang,S., Ohkubo,T., Xie,L., Zhang,Y., Li,G., Liu,C., Tian,H., Zhang,Y., Zhang,M.R. and Wang,R.<br>A Cyclic Peptide-Based Radiotheranostic Agent for Urokinase-Type Plasminogen Activator in Tumors<br>Chemistry (2025) , e202500479-e202500479. PubMed  Europe PubMed DOI
    4. 2024
  4. Torres-Paris,C., Song,H.J., Engelberger,F., Ramirez-Sarmiento,C.A. and Komives,E.A.<br>The Light Chain Allosterically Enhances the Protease Activity of Murine Urokinase-Type Plasminogen Activator<br>Biochemistry (2024) 63, 1434-1444. PubMed  Europe PubMed DOI
    5. 2023
  5. Alfieri,M., Meo,L. and Ragno,P.<br>Posttranscriptional Regulation of the Plasminogen Activation System by Non-Coding RNA in Cancer<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
  6. Hu,X., Sun,X., Liu,X., Xu,H.D., Yang,L., Liu,S., Wang,R. and Liang,G.<br>Enhanced Photoacoustic Imaging of Urokinase-Type Plasminogen Activator Activity in Tumors<br>Anal Chem (2023) 95, 14511-14515. PubMed  Europe PubMed DOI
  7. Kanno,Y.<br>The uPA/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression<br>Int J Mol Sci (2023) 24 PubMed  Europe PubMed DOI  PMC  EPMC  V
  8. Kondo,Y., Rajapakse,S. and Ogiwara,K.<br>Involvement of cathepsin L in the degradation and degeneration of postovulatory follicle of the medaka ovarydagger<br>Biol Reprod (2023) 109, 904-917. PubMed  Europe PubMed DOI
  9. Mazzocato,Y., Perin,S., Morales-Sanfrutos,J., Romanyuk,Z., Pluda,S., Acquasaliente,L., Borsato,G., De Filippis,V., Scarso,A. and Angelini,A.<br>A novel genetically-encoded bicyclic peptide inhibitor of human urokinase-type plasminogen activator with better cross-reactivity toward the murine orthologue<br>Bioorg Med Chem (2023) 95, 117499-117499. PubMed  Europe PubMed DOI  I
  10. Micalet,A., Tappouni,L.J., Peszko,K., Karagianni,D., Lam,A., Counsell,J.R., Quezada,S.A., Moeendarbary,E. and Cheema,U.<br>Urokinase-type plasminogen activator (uPA) regulates invasion and matrix remodelling in colorectal cancer<br>Matrix Biol Plus (2023) 19-20, 100137-100137. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Tan,J., Ge,Y., Zhang,M. and Ding,M.<br>Proteomics analysis uncovers plasminogen activator PLAU as a target of the STING pathway for suppression of cancer cell migration and invasion<br>J Biol Chem (2023) 299, 102779-102779. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Torres-Paris,C., Chen,Y., Xiao,L., Song,H.J., Chen,P. and Komives,E.A.<br>The autoactivation of human single-chain urokinase-type plasminogen activator (uPA)<br>J Biol Chem (2023) 299, 105179-105179. PubMed  Europe PubMed DOI  PMC  EPMC
    13. 2022
  13. Arancillo,M., Lin,C.M. and Burgess,K.<br>Piptide Chemotypes for Perturbation of the Interaction of Urokinase with Its Receptor<br>J Med Chem (2022) 65, 12925-12932. PubMed  Europe PubMed DOI
  14. Cheung,E.Y.H., Chan,D.Y.C., Lee,M.W.Y., Hung,C.Y. and Pang,K.Y.<br>Urokinase Is Safe and Effective in Reducing Recurrence in Chronic Subdural Hematoma After Burr-Hole Drainage<br>World Neurosurg (2022) 164, e1209-e1209. PubMed  Europe PubMed DOI
  15. Diaz,A., Martin-Jimenez,C., Woo,Y., Merino,P., Torre,E. and Yepes,M.<br>Urokinase-Type Plasminogen Activator Triggers Wingless/Int1-Independent Phosphorylation of the Low-Density Lipoprotein Receptor-Related Protein-6 in Cerebral Cortical Neurons<br>J Alzheimers Dis (2022) 89, 877-891. PubMed  Europe PubMed DOI
  16. Dreymann,N., Wuensche,J., Sabrowski,W., Moeller,A., Czepluch,D., Vu Van,D., Fuessel,S. and Menger,M.M.<br>Inhibition of Human Urokinase-Type Plasminogen Activator (uPA) Enzyme Activity and Receptor Binding by DNA Aptamers as Potential Therapeutics through Binding to the Different Forms of uPA<br>Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  17. El Salamouni,N.S., Buckley,B.J., Ranson,M., Kelso,M.J. and Yu,H.<br>Urokinase plasminogen activator as an anti-metastasis target: inhibitor design principles, recent amiloride derivatives, and issues with human/mouse species selectivity<br>Biophys Rev (2022) 14, 277-301. PubMed  Europe PubMed DOI  PMC  EPMC  V
  18. Ganguly,R., Mylliemngap,B.J. and Bhattacharjee,A.<br>Discovery of a novel inhibitor against urokinase-type plasminogen activator, a potential enzyme with a role in atherosclerotic plaque instability<br>J Biomol Struct Dyn (2022) , 1-11. PubMed  Europe PubMed DOI
  19. Gao,C., Tang,S., Zhang,H., Zhang,H., Zhang,T., Bao,B., Zhu,Y. and Wu,W.<br>A Novel Marine Pyran-Isoindolone Compound Enhances Fibrin Lysis Mediated by Single-Chain Urokinase-Type Plasminogen Activator<br>Mar Drugs (2022) 20 PubMed  Europe PubMed DOI  PMC  EPMC
  20. Mehner,C., Hockla,A., Coban,M., Madden,B., Estrada,R., Radisky,D.C. and Radisky,E.S.<br>Activity-based protein profiling reveals active serine proteases that drive malignancy of human ovarian clear cell carcinoma<br>J Biol Chem (2022) 298, 102146-102146. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Moro,G., Severin Sfragano,P., Ghirardo,J., Mazzocato,Y., Angelini,A., Palchetti,I. and Polo,F.<br>Bicyclic peptide-based assay for uPA cancer biomarker<br>Biosens Bioelectron (2022) 213, 114477-114477. PubMed  Europe PubMed DOI
  22. Tagirasa,R. and Yoo,E.<br>Role of Serine Proteases at the Tumor-Stroma Interface<br>Front Immunol (2022) 13, 832418-832418. PubMed  Europe PubMed DOI  PMC  EPMC  V
  23. Yepes,M.<br>The uPA/uPAR system in astrocytic wound healing<br>Neural Regen Res (2022) 17, 2404-2406. PubMed  Europe PubMed DOI  PMC  EPMC
  24. Zhou,Y., Wu,J., Xue,G., Li,J., Jiang,L. and Huang,M.<br>Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat<br>Biophys J (2022) 121, 3940-3949. PubMed  Europe PubMed DOI  PMC  EPMC  I
  25. Zhu,R., Liu,T.W. and Liu,F.<br>Exogenous Urokinase Inhibits Proteasomal Degradation of Its Cognate Urokinase Plasminogen Activator Receptor<br>Front Pharmacol (2022) 13, 754271-754271. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 2021
  26. Bum-Erdene,K., Liu,D., Xu,D., Ghozayel,M.K. and Meroueh,S.O.<br>Design and Synthesis of Fragment Derivatives with a Unique Inhibition Mechanism of the uPAR.uPA Interaction<br>ACS Med Chem Lett (2021) 12, 60-66. PubMed  Europe PubMed DOI  PMC  EPMC
  27. Diaz,A., Martin-Jimenez,C., Xu,Y., Merino,P., Woo,Y., Torre,E. and Yepes,M.<br>Urokinase-type plasminogen activator-mediated crosstalk between N-cadherin and beta-Catenin promotes wound healing<br>J Cell Sci (2021) PubMed  Europe PubMed DOI
  28. Ismail,A.A., Shaker,B.T. and Bajou,K.<br>The Plasminogen-Activator Plasmin System in Physiological and Pathophysiological Angiogenesis<br>Int J Mol Sci (2021) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  29. Kryza,T., Khan,T., Lovell,S., Harrington,B.S., Yin,J., Porazinski,S., Pajic,M., Koistinen,H., Rantala,J.K., Dreyer,T., Magdolen,V., Reuning,U., He,Y., Tate,E.W. and Hooper,J.D.<br>Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1<br>Nat Chem Biol (2021) PubMed  Europe PubMed DOI
  30. Salamouni,S.E., Buckley,B.J., Jiang,L., Huang,M., Ranson,M., Kelso,M.J. and Yu,H.<br>Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA)<br>J Med Chem (2021) PubMed  Europe PubMed DOI
  31. Tucker,T.A. and Idell,S.<br>The Contribution of the Urokinase Plasminogen Activator and the Urokinase Receptor to Pleural and Parenchymal Lung Injury and Repair: A Narrative Review<br>Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC  V
  32. Vorstandlechner,V., Laggner,M., Copic,D., Klas,K., Direder,M., Chen,Y., Golabi,B., Haslik,W., Radtke,C., Tschachler,E., Hotzenecker,K., Ankersmit,H.J. and Mildner,M.<br>The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation<br>Nat Commun (2021) 12, 6242-6242. PubMed  Europe PubMed DOI  PMC  EPMC
    33. 2020
  33. Almholt,K., Wang,J., Pass,J., Roder,G., Padkjaer,S.B., Hebsgaard,J.B., Xia,W., Yang,L., Forsell,J., Breinholt,V.M., Thygesen,P., Agerso,H., Loftager,M. and Usher,P.A.<br>Identification and preclinical development of an anti-proteolytic uPA antibody for rheumatoid arthritis<br>J Mol Med (Berl) (2020) 98, 585-593. PubMed  Europe PubMed DOI  U
  34. Belfiore,L., Saunders,D.N., Ranson,M. and Vine,K.L.<br>N-Alkylisatin-Loaded Liposomes Target the Urokinase Plasminogen Activator System in Breast Cancer<br>Pharmaceutics (2020) 12 PubMed  Europe PubMed DOI
  35. Brunet,J.G., Sharma,T., Tasneem,S., Liang,M., Wilson,M.D., Rivard,G.E. and Hayward,C.P.M.<br>Thrombin generation abnormalities in Quebec platelet disorder<br>Int J Lab Hematol (2020) , e13302-e13302. PubMed  Europe PubMed DOI  I
  36. Joossen,C., Baan,A., Moreno-Cinos,C., Joossens,J., Cools,N., Lanckacker,E., Moons,L., Lemmens,K., Lambeir,A.M., Fransen,E., Delputte,P., Caljon,G., Van der Veken,P., Maes,L., De Meester,I., Kiekens,F., Augustyns,K. and Cos,P.<br>A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation<br>Sci Rep (2020) 10, 17268-17268. PubMed  Europe PubMed DOI  PMC  EPMC  I
  37. Nassir,A.M. and Kamel,H.F.M.<br>Explication of the roles of prostate health index (PHI) and urokinase plasminogen activator (uPA) as diagnostic and predictor tools for prostate cancer in equivocal PSA range of 4-10 ng/mL<br>Saudi J Biol Sci (2020) 27, 1975-1984. PubMed  Europe PubMed DOI  PMC  EPMC
  38. Pulukuri,S.M.K., Gorantla,B. and Rao,J.S.<br>Retraction: Inhibition of histone deacetylase activity promotes invasion of human cancer cells through activation of urokinase plasminogen activator<br>J Biol Chem (2020) 295, 13407-13407. PubMed  Europe PubMed DOI  PMC  EPMC
  39. Sevillano,N., Bohn,M.F., Zimanyi,M., Chen,Y., Petzold,C., Gupta,S., Ralston,C.Y. and Craik,C.S.<br>Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity<br>Biochim Biophys Acta Proteins Proteom (2020) 1869, 140562-140562. PubMed  Europe PubMed DOI
  40. Westrick,R.J., Rojkjaer,L.P., Yang,A.Y., Roh,M.H., Siebert,A.E. and Ginsburg,D.<br>Deficiency of Plasminogen Activator Inhibitor-2 Results in Accelerated Tumor Growth<br>J Thromb Haemost (2020) 18, 2968-2975. PubMed  Europe PubMed DOI
  41. Yang,B., Zhang,D., Qian,J. and Cheng,Y.<br>Chelerythrine suppresses proliferation and metastasis of human prostate cancer cells via modulating MMP/TIMP/NF-kappaB system<br>Mol Cell Biochem (2020) 474, 199-208. PubMed  Europe PubMed DOI
    42. 2019
  42. Buckley,B.J., Majed,H., Aboelela,A., Minaei,E., Jiang,L., Fildes,K., Cheung,C.Y., Johnson,D., Bachovchin,D., Cook,G.M., Huang,M., Ranson,M. and Kelso,M.J.<br>6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease<br>Bioorg Med Chem Lett (2019) , 126753-126753. PubMed  Europe PubMed DOI  S  I
  43. Chana-Munoz,A., Jendroszek,A., Sonnichsen,M., Wang,T., Ploug,M., Jensen,J.K., Andreasen,P.A., Bendixen,C. and Panitz,F.<br>Origin and diversification of the plasminogen activation system among chordates<br>BMC Evol Biol (2019) 19, 27-27. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Jendroszek,A., Madsen,J.B., Chana-Munoz,A., Dupont,D.M., Christensen,A., Panitz,F., Fuchtbauer,E.M., Lovell,S.C. and Jensen,J.K.<br>Biochemical and structural analyses suggest that plasminogen activators coevolved with their cognate protein substrates and inhibitors<br>J Biol Chem (2019) 294, 3794-3805. PubMed  Europe PubMed DOI
  45. Li,C.Y., de Veer,S.J., Law,R.H.P., Whisstock,J.C., Craik,D.J. and Swedberg,J.E.<br>Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library<br>Chembiochem (2019) 20, 46-50. PubMed  Europe PubMed DOI  P  I
  46. Wang,D., Yang,Y., Jiang,L., Wang,Y., Li,J., Andreasen,P.A., Chen,Z., Huang,M. and Xu,P.<br>Suppression of tumor growth and metastases by targeted intervention in urokinase activity with cyclic peptides<br>J Med Chem (2019) 62, 2172-2183. PubMed  Europe PubMed DOI  I
  47. Wu,G., Mazzitelli,B.A., Quek,A.J., Veldman,M.J., Conroy,P.J., Caradoc-Davies,T.T., Ooms,L.M., Tuck,K.L., Schoenecker,J.G., Whisstock,J.C. and Law,R.H.P.<br>Tranexamic acid is an active site inhibitor of urokinase plasminogen activator<br>Blood Adv (2019) 3, 729-733. PubMed  Europe PubMed DOI  I
    48. 2018
  48. Almholt,K., Hebsgaard,J.B., Nansen,A., Andersson,C., Pass,J., Rono,B., Thygesen,P., Pelzer,H., Loftager,M., Lund,I.K., Hoyer-Hansen,G., Frisch,T., Jensen,C.H., Otte,K.S., Soe,N.H., Bartels,E.M., Andersen,M., Bliddal,H. and Usher,P.A.<br>Antibody-mediated neutralization of uPA proteolytic function reduces disease progression in mouse arthritis models<br>J Immunol (2018) 200, 957-965. PubMed  Europe PubMed DOI
  49. Buckley,B.J., Aboelela,A., Minaei,E., Jiang,L.X., Xu,Z., Ali,U., Fildes,K., Cheung,C.Y., Cook,S.M., Johnson,D.C., Bachovchin,D.A., Cook,G.M., Apte,M., Huang,M., Ranson,M. and Kelso,M.J.<br>6-Substituted hexamethylene amiloride (HMA) derivatives as potent and selective inhibitors of the human urokinase plasminogen activator for use in cancer<br>J Med Chem (2018) 61, 8299-8320. PubMed  Europe PubMed DOI  I
  50. Ding,X., Li,H., Li,Y., Huang,D. and Xiong,C.<br>Two B-cell epitope vaccines based on uPA effectively inhibit fertility in male mice<br>Vaccine (2018) 36, 2612-2618. PubMed  Europe PubMed DOI
  51. Islam,I., Yuan,S., West,C.W., Adler,M., Bothe,U., Bryant,J., Chang,Z., Chu,K., Emayan,K., Gualtieri,G., Ho,E., Light,D., Mallari,C., Morser,J., Phillips,G., Schaefer,C., Sukovich,D., Whitlow,M., Chen,D. and Buckman,B.O.<br>Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis<br>Bioorg Med Chem Lett (2018) 28, 3372-3375. PubMed  Europe PubMed DOI  I
  52. Merino,P. and Yepes,M.<br>Urokinase-type plasminogen activator induces neurorepair in the ischemic brain<br>J Neurol Exp Neurosci (2018) 4, 24-29. PubMed  Europe PubMed DOI  PMC  EPMC
  53. Solis-Calero,C., Zanatta,G., Pessoa,C.D.O., Carvalho,H.F. and Freire,V.N.<br>Explaining urokinase type plasminogen activator inhibition by amino-5-hydroxybenzimidazole and two naphthamidine-based compounds through quantum biochemistry<br>Phys Chem Chem Phys (2018) 20, 22818-22830. PubMed  Europe PubMed DOI  I
    54. 2017
  54. Cerisier,N., Regad,L., Triki,D., Camproux,A.C. and Petitjean,M.<br>Cavity versus ligand shape descriptors: application to urokinase binding pockets<br>J Comput Biol (2017) 24, 1134-1137. PubMed  Europe PubMed DOI
  55. Kromann-Hansen,T., Louise Lange,E., Peter Sorensen,H., Hassanzadeh-Ghassabeh,G., Huang,M., Jensen,J.K., Muyldermans,S., Declerck,P.J., Komives,E.A. and Andreasen,P.A.<br>Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator<br>Sci Rep (2017) 7, 3385-3385. PubMed  Europe PubMed DOI  PMC  EPMC
  56. Tan,Q., Chen,Q., Niu,Y., Feng,Z., Li,L., Tao,Y., Tang,J., Yang,L., Guo,J., Feng,H., Zhu,G. and Chen,Z.<br>Urokinase, a promising candidate for fibrinolytic therapy for intracerebral hemorrhage<br>J Neurosurg (2017) 126, 548-557. PubMed  Europe PubMed DOI
  57. Xue,G., Gong,L., Yuan,C., Xu,M., Wang,X., Jiang,L. and Huang,M.<br>A structural mechanism of flavonoids in inhibiting serine proteases<br>Food Funct (2017) 8, 2437-2443. PubMed  Europe PubMed DOI  S  I
  58. Zhao,K., Liu,Y., Xiong,Z., Hu,L. and Xiong,C.L.<br>Tissue-specific inhibition of urokinase-type plasminogen activator expression in the testes of mice by inducible lentiviral RNA interference causes male infertility<br>Reprod Fertil Dev (2017) 29, 2149-2156. PubMed  Europe PubMed DOI  K
    59. 2016
  59. Dupont,D.M., Bjerregaard,N., Verpaalen,B., Andreasen,P.A. and Jensen,J.K.<br>Building a molecular trap for a serine protease from aptamer and peptide modules<br>Bioconjug Chem (2016) 27, 918-926. PubMed  Europe PubMed DOI
  60. Gong,L., Proulle,V., Fang,C., Hong,Z., Lin,Z., Liu,M., Xue,G., Yuan,C., Lin,L., Furie,B., Flaumenhaft,R., Andreasen,P., Furie,B. and Huang,M.<br>A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase<br>J Cell Mol Med (2016) 20, 1851-1860. PubMed  Europe PubMed DOI
  61. Jiang,L., Andersen,L.M., Andreasen,P.A., Chen,L. and Huang,M.<br>Insights into the serine protease mechanism based on structural observations of the conversion of a peptidyl serine protease inhibitor to a substrate<br>Biochim Biophys Acta (2016) 1860, 599-606. PubMed  Europe PubMed DOI  S  I
  62. Maleki,A., Tohidi-Zand,S.R., Amirizadeh,N., Dehghan-Haghighi,J., Zanjani,H., Arish,M., Salari,A.M., Mirhosseini,S.M. and Abrishami,M.<br>Intravitreal autologous plasmin prepared by urokinase for vitreolysis: a pilot study<br>Eur J Ophthalmol (2016) 26, 67-70. PubMed  Europe PubMed DOI
    63. 2015
  63. Beloglazova,I.B., Plekhanova,O.S., Katkova,E.V., Rysenkova,K.D., Stambol'skii,D.V., Sulimov,V.B. and Tkachuk,V.A.<br>Molecular modeling as a new approach to the development of urokinase inhibitors<br>Bull Exp Biol Med (2015) 158, 700-704. PubMed  Europe PubMed DOI  I
  64. Fasoli,E., Righetti,P.G., Moltrasio,D. and D'Amato,A.<br>Extensive heterogeneity of human urokinase, as detected by two-dimensional mapping<br>Anal Chem (2015) 87, 1509-1513. PubMed  Europe PubMed DOI
  65. Gladysz,R., Adriaenssens,Y., De Winter,H., Joossens,J., Lambeir,A.M., Augustyns,K. and Van der Veken,P.<br>Discovery and SAR of novel and selective inhibitors of urokinase plasminogen activator (uPA) with an imidazo[1,2-a]pyridine scaffold<br>J Med Chem (2015) 58, 9238-9257. PubMed  Europe PubMed DOI  I
  66. Jiang,L., Zhao,B., Xu,P., Sorensen,H.P., Jensen,J.K., Christensen,A., Hosseini,M., Nielsen,N.C., Jensen,K.J., Andreasen,P.A. and Huang,M.<br>Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues<br>Int J Biochem Cell Biol (2015) 62, 88-92. PubMed  Europe PubMed DOI  I
  67. Lebeau,A.M., Sevillano,N., Markham,K., Winter,M.B., Murphy,S.T., Hostetter,D.R., West,J., Lowman,H., Craik,C.S. and Vanbrocklin,H.F.<br>Imaging active urokinase plasminogen activator in prostate cancer<br>Cancer Res (2015) 75, 1225-1235. PubMed  Europe PubMed DOI  L
  68. Qin,Y., Han,Y., Xiong,C.L., Li,H.G., Hu,L. and Zhang,L.<br>Urokinase-type plasminogen activator: a new target for male contraception?<br>Asian J Androl (2015) 17, 269-273. PubMed  Europe PubMed DOI
  69. Sorensen,H.P., Xu,P., Jiang,L., Kromann-Hansen,T., Jensen,K.J., Huang,M. and Andreasen,P.A.<br>Selection of high-affinity peptidic serine protease inhibitors with increased binding entropy from a back-flip library of peptide-protease fusions<br>J Mol Biol (2015) 427, 3110-3122. PubMed  Europe PubMed DOI  I
    70. 2014
  70. Faid,V., Denguir,N., Chapuis,V., Bihoreau,N. and Chevreux,G.<br>Site-specific N-glycosylation analysis of human factor XI: identification of a noncanonical NXC glycosite<br>Proteomics (2014) 14, 2460-2470. PubMed  Europe PubMed DOI
  71. Mekkawy,A.H., Pourgholami,M.H. and Morris,D.L.<br>Involvement of urokinase-type plasminogen activator system in cancer: an overview<br>Med Res Rev (2014) 34, 918-956. PubMed  Europe PubMed DOI  V
  72. Popa,N.L., Wergedal,J.E., Lau,K.H., Mohan,S. and Rundle,C.H.<br>Urokinase plasminogen activator gene deficiency inhibits fracture cartilage remodeling<br>J Bone Miner Metab (2014) 32, 124-135. PubMed  Europe PubMed DOI  K
  73. Sulimov,V.B., Katkova,E.V., Oferkin,I.V., Sulimov,A.V., Romanov,A.N., Roschin,A.I., Beloglazova,I.B., Plekhanova,O.S., Tkachuk,V.A. and Sadovnichiy,V.A.<br>Application of molecular modeling to urokinase inhibitors development<br>Biomed Res Int (2014) 2014, 625176-625176. PubMed  Europe PubMed DOI  PMC  EPMC  I
  74. Zhao,B., Xu,P., Jiang,L., Paaske,B., Kromann-Hansen,T., Jensen,J.K., Sorensen,H.P., Liu,Z., Nielsen,J.T., Christensen,A., Hosseini,M., Sorensen,K.K., Nielsen,N.C., Jensen,K.J., Huang,M. and Andreasen,P.A.<br>A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility<br>PLoS ONE (2014) 9, e115872-e115872. PubMed  Europe PubMed DOI  S  I
    75. 2013
  75. Chen,S., Gfeller,D., Buth,S.A., Michielin,O., Leiman,P.G. and Heinis,C.<br>Improving binding affinity and stability of peptide ligands by substituting glycines with d-amino acids<br>Chembiochem (2013) 14, 1316-1322. PubMed  Europe PubMed DOI  I
  76. Fasoli,E., Reyes,Y.R., Guzman,O.M., Rosado,A., Cruz,V.R., Borges,A., Martinez,E. and Bansal,V.<br>Para-aminobenzamidine linked regenerated cellulose membranes for plasminogen activator purification: Effect of spacer arm length and ligand density<br>J Chromatogr B Analyt Technol Biomed Life Sci (2013) 930, 13-21. PubMed  Europe PubMed DOI  I
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