$VAR1 = undef;

Summary for peptidase S01.174: mesotrypsin

Names
MEROPS Name	mesotrypsin
Other names	brain trypsin (Homo sapiens), mesotrypsinogen (activated), PRSS3 g.p. (Homo sapiens), PRSS4 g.p. (Homo sapiens), trypsin IV (Homo sapiens), trypsin-3 (Homo sapiens), trypsinogen-3 (Homo sapiens), trypsin-4 (Homo sapiens), trypsinogen IV, zymogen-X (activated)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.174
Holotype	mesotrypsin (Homo sapiens), Uniprot accession P35030 (peptidase unit: 24-246), MERNUM MER0000022
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (5 cleavages)
Pathways	KEGG	Influenza A
	KEGG	Neuroactive ligand-receptor interaction
	KEGG	Pancreatic secretion
	KEGG	Protein digestion and absorption
Other databases	TREEFAM	http://www.treefam.org/family/TF331065
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/pag/RK-/-/-/il (based on 22 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	4	3	4	0	2	3	0	2
Pro	1	4	7	0	0	1	4	3
Ala	2	2	4	0	2	2	0	0
Val	1	0	0	0	1	0	0	0
Leu	2	1	0	0	0	2	1	4
Ile	1	2	0	0	2	1	3	4
Met	0	0	0	0	0	1	0	0
Phe	0	0	0	0	0	1	3	0
Tyr	0	0	1	0	0	2	0	1
Trp	0	0	0	0	0	0	0	0
Ser	4	0	0	0	4	1	2	2
Thr	0	1	1	0	4	1	2	0
Cys	0	1	2	0	0	0	0	2
Asn	1	1	0	0	0	0	0	0
Gln	0	0	2	0	1	1	0	0
Asp	2	1	0	0	0	1	2	0
Glu	0	0	0	0	1	0	0	1
Lys	0	2	1	6	0	0	1	0
Arg	0	1	0	16	0	2	0	0
His	1	3	0	0	2	0	1	0

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
PRSS3	9p13		ENSG00000010438	5646	PRSS3