Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P07477

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
15	unknown peptidase	1-247	P	release of a signal peptide	NT	Kimland et al., 1989
18	chymotrypsin C	16-247	P		NT	Nemoda & Sahin-Tóth, 2006
23	penicillopepsin	16-247	N			Hofmann, 2004
41	chymotrypsin C	24-81	P		NT	Szmola & Sahin-Toth, 2007
80	HIV-1 retropepsin	79-92	N		MS	Schilling & Overall, 2008
81	chymotrypsin C	24-247	P		NT	Szmola & Sahin-Toth, 2007
92	trypsin 1	24-247	N		MS	Schilling & Overall, 2008
102	trypsin 1	24-247	N		MS	Schilling & Overall, 2008
103	cathepsin S	103-112	N		MS	Biniossek et al., 2011
103	matrix metallopeptidase-2	102-112	N		MS	Schilling & Overall, 2008
112	trypsin 1	24-247	N		MS	Schilling & Overall, 2008
122	cationic trypsin (Homo sapiens-type)	82-247	P		NT	Szmola & Sahin-Toth, 2007
122	mesotrypsin	24-247	P		CS	Szmola et al., 2003
189	cathepsin L	179-206	N		MS	Biniossek et al., 2011
189	cathepsin S	179-206	N		MS	Biniossek et al., 2011
190	cathepsin L	179-206	N		MS	Biniossek et al., 2011