Structure for peptidase S01.174: mesotrypsin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
2R9P_A Homo sapiens 1.40 Å complex with bovine pancreatic trypsin inhibitor
One monomer of the tetramer is shown. Catalytic residues are shown in ball-and-stick representation: His63 in purple, Asp107 in pink and Ser200 in orange. The bound inhibitor is shown in grey ribbon representation.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Homo sapiens
mature  peptidase 1.70 Å 1H4W 1H4W 1H4W 1H4W 1H4W 1H4W Katona et al., 2002
complex with bovine pancreatic trypsin inhibitor 1.40 Å 2R9P 2R9P 2R9P 2R9P 2R9P 2R9P Salameh et al., 2008
complex with amyloid precursor protein inhibitor(appi) 2.48 Å 3L33 3L33 3L33 3L33 3L33 3L33
complex with amyloid precursor protein inhibitor variant (appir15k) 2.38 Å 3L3T 3L3T 3L3T 3L3T 3L3T 3L3T
human mesotrypsin in complex with amyloid precursor protein inhibitor variant appi-m17g/i18f/f34v 1.83 Å 5C67 5C67 5C67 5C67 5C67 5C67
mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (aplp2) 1.40 Å 5JBT 5JBT 5JBT 5JBT 5JBT 5JBT
complex with diminazene 1.25 Å 5TP0 5TP0 5TP0 5TP0 5TP0 5TP0
complex with tissue factor pathway inhibitor variant (tfpi1-kd1-k15r-i17c-i34c) 1.98 Å 6BX8 6BX8 6BX8 6BX8 6BX8 6BX8
complex with appi variant t11v/m17r/i18f/f34v 2.30 Å 6GFI 6GFI 6GFI 6GFI 6GFI 6GFI
complex with appi-m17c/i18f/f34c 1.50 Å 6HAR 6HAR 6HAR 6HAR 6HAR 6HAR