Literature for peptidase S01.174: mesotrypsin

(Topics flags: S Structure, T Target, R Splicing, I Inhibitor, P Specificity, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Nie,L., Zhang,X. and Wu,J.
   PRSS3 is a potential prognostic biomarker for lung adenocarcinoma
   Transl Cancer Res14, 1124-1140. PubMed  Europe PubMed DOI
2024
2. Moreau,T., Recoules,E., De Pauw,M., Labas,V. and Rehault-Godbert,S.
   Evidence that the Bowman-Birk inhibitor from Pisum sativum affects intestinal proteolytic activities in chickens
   Poult Sci103, 103182-103182. PubMed  Europe PubMed DOI  L
2023
3. Sananes,A., Cohen,I., Allon,I., Ben-David,O., Abu Shareb,R., Yegodayev,K.M., Stepensky,D., Elkabets,M. and Papo,N.
   Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers
   Mol Oncol17, 2337-2355. PubMed  Europe PubMed DOI
2022
4. Koistinen,H., Koistinen,R., Hotakainen,K., Lempiainen,A., Jokelainen,K., Farkkila,M. and Stenman,U.H.
   Immunoassay for trypsinogen-4
   Anal Biochem648, 114681-114681. PubMed  Europe PubMed DOI
5. Rattanakomol,P., Srimanote,P., Tongtawe,P., Khantisitthiporn,O., Supasorn,O. and Thanongsaksrikul,J.
   Host neuronal PRSS3 interacts with enterovirus A71 3A protein and its role in viral replication
   Sci Rep12, 12846-12846. PubMed  Europe PubMed DOI
2021
6. Zhang,Q., Wang,J., Huang,D. and Liu,G.
   High Expression of PRSS3 Indicates Unfavorable Clinical Outcomes in Colon Adenocarcinoma
   Appl Immunohistochem Mol Morphol29, 564-569. PubMed  Europe PubMed DOI
2020
7. Ramesh,K., Matta,S.A., Chew,F.T. and Mok,Y.K.
   Exonic mutations associated with atopic dermatitis disrupt lympho-epithelial Kazal-type related inhibitor action and enhance its degradation
   Allergy75, 403-411. PubMed  Europe PubMed DOI
8. Toldi,V., Szabo,A. and Sahin-Toth,M.
   Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation
   J Biol Chem295, 3447-3455. PubMed  Europe PubMed DOI
2019
9. Cohen,I., Coban,M., Shahar,A., Sankaran,B., Hockla,A., Lacham,S., Caulfield,T.R., Radisky,E.S. and Papo,N.
   Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin
   J Biol Chem294, 5105-5120. PubMed  Europe PubMed DOI  S
2018
10. Cohen,I., Naftaly,S., Ben-Zeev,E., Hockla,A., Radisky,E.S. and Papo,N.
    Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases
    Biochem J475, 1335-1352. PubMed  Europe PubMed DOI
11. de Veer,S.J., Li,C.Y., Swedberg,J.E., Schroeder,C.I. and Craik,D.J.
    Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1
    Eur J Med Chem155, 695-704. PubMed  Europe PubMed DOI
12. Schilling,O., Biniossek,M.L., Mayer,B., Elsasser,B., Brandstetter,H., Goettig,P., Stenman,U.H. and Koistinen,H.
    Specificity profiling of human trypsin-isoenzymes
    Biol Chem399, 997-1007. PubMed  Europe PubMed DOI  P
2017
13. Kayode,O., Huang,Z., Soares,A.S., Caulfield,T.R., Dong,Z., Bode,A.M. and Radisky,E.S.
    Small molecule inhibitors of mesotrypsin from a structure-based docking screen
    PLoS ONE12, e0176694-e0176694. PubMed  Europe PubMed DOI  S  I
2016
14. Cohen,I., Kayode,O., Hockla,A., Sankaran,B., Radisky,D.C., Radisky,E.S. and Papo,N.
    Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy
    Biochem J473, 1329-1341. PubMed  Europe PubMed DOI
15. Kayode,O., Wang,R., Pendlebury,D.F., Cohen,I., Henin,R.D., Hockla,A., Soares,A.S., Papo,N., Caulfield,T.R. and Radisky,E.S.
    An acrobatic substrate metamorphosis reveals a requirement for substrate conformational dynamics in trypsin proteolysis
    J Biol Chem291, 26304-26319. PubMed  Europe PubMed DOI  S
2015
16. Alloy,A.P., Kayode,O., Wang,R., Hockla,A., Soares,A.S. and Radisky,E.S.
    Mesotrypsin has evolved four unique residues to cleave trypsin inhibitors as substrates
    J Biol Chem290, 21523-21535. PubMed  Europe PubMed DOI
17. Ghilardi,C., Silini,A., Figini,S., Anastasia,A., Lupi,M., Fruscio,R., Giavazzi,R. and Bani,M.R.
    Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2
    Oncotarget6, 28389-28400. PubMed  Europe PubMed DOI
18. Szabo,A., Ludwig,M., Hegyi,E., Szepeova,R., Witt,H. and Sahin-Toth,M.
    Mesotrypsin signature mutation in a chymotrypsin C (CTRC) variant associated with chronic pancreatitis
    J Biol Chem290, 17282-17292. PubMed  Europe PubMed DOI
2014
19. Haerteis,S., Krappitz,A., Krappitz,M., Murphy,J.E., Bertog,M., Krueger,B., Nacken,R., Chung,H., Hollenberg,M.D., Knecht,W., Bunnett,N.W. and Korbmacher,C.
    Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites
    J Biol Chem289, 19067-19078. PubMed  Europe PubMed DOI  P
20. Miyai,M., Matsumoto,Y., Yamanishi,H., Yamamoto-Tanaka,M., Tsuboi,R. and Hibino,T.
    Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation
    J Invest Dermatol134, 1665-1674. PubMed  Europe PubMed DOI
21. Pendlebury,D., Wang,R., Henin,R.D., Hockla,A., Soares,A.S., Madden,B.J., Kazanov,M.D. and Radisky,E.S.
    Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin
    J Biol Chem289, 32783-32797. PubMed  Europe PubMed DOI
22. Yamamoto-Tanaka,M., Motoyama,A., Miyai,M., Matsunaga,Y., Matsuda,J., Tsuboi,R. and Hibino,T.
    Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation
    J Biol Chem289, 20026-20038. PubMed  Europe PubMed DOI
2013
23. Han,S., Lee,C.W., Trevino,J.G., Hughes,S.J. and Sarosi,G.A., Jr.
    Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma
    PLoS ONE8, e76667-e76667. PubMed  Europe PubMed DOI
24. Salameh,M.A. and Radisky,E.S.
    Biochemical and structural insights into mesotrypsin: an unusual human trypsin
    Intl J Biochem Mol Biol4, 129-139. PubMed  Europe PubMed  V
2012
25. Chen,J.M., Radisky,E.S. and Ferec,C.
    Human trypsins
    [ISSN:978-0-12-407742-3]3, 2600-2609. DOI
26. Dhakal,B.K. and Mulvey,M.A.
    The UPEC pore-forming toxin alpha-hemolysin triggers proteolysis of host proteins to disrupt cell adhesion, inflammatory, and survival pathways
    Cell Host Microbe11, 58-69. PubMed  Europe PubMed DOI
27. Hockla,A., Miller,E., Salameh,M.A., Copland,J.A., Radisky,D.C. and Radisky,E.S.
    PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancer
    Mol Cancer Res10, 1555-1566. PubMed  Europe PubMed DOI  T
28. Karle,M., Knecht,W. and Xue,Y.
    Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV
    Bioorg Med Chem Lett22, 4839-4843. PubMed  Europe PubMed DOI  I
29. Petronella,N. and Drouin,G.
    Strong purifying selection against gene conversions in the trypsin genes of primates
    Hum Genet131, 1739-1749. PubMed  Europe PubMed DOI
30. Salameh,M.A., Soares,A.S., Alloy,A. and Radisky,E.S.
    Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors
    Protein Sci21, 1103-1112. PubMed  Europe PubMed DOI  S
2011
31. Ceppa,E.P., Lyo,V., Grady,E.F., Knecht,W., Grahn,S., Peterson,A., Bunnett,N.W., Kirkwood,K.S. and Cattaruzza,F.
    Serine proteases mediate inflammatory pain in acute pancreatitis
    Am J Physiol Gastrointest Liver Physiol300, G1033-G1042. PubMed  Europe PubMed DOI  T
32. Salameh,M.A., Soares,A.S., Hockla,A., Radisky,D.C. and Radisky,E.S.
    The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity
    Biochem J440, 95-105. PubMed  Europe PubMed DOI  P
2010
33. Hockla,A., Radisky,D.C. and Radisky,E.S.
    Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109
    Breast Cancer Res Treat124, 27-38. PubMed  Europe PubMed DOI
34. Salameh,M.A., Soares,A.S., Navaneetham,D., Sinha,D., Walsh,P.N. and Radisky,E.S.
    Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin
    J Biol Chem285, 36884-36896. PubMed  Europe PubMed DOI
35. Salameh,M.A., Robinson,J.L., Navaneetham,D., Sinha,D., Madden,B.J., Walsh,P.N. and Radisky,E.S.
    The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin
    J Biol Chem285, 1939-1949. PubMed  Europe PubMed DOI  P
36. Wu,P., Weisell,J., Pakkala,M., Perakyla,M., Zhu,L., Koistinen,R., Koivunen,E., Stenman,U.H., Narvanen,A. and Koistinen,H.
    Identification of novel peptide inhibitors for human trypsins
    Biol Chem391, 283-293. PubMed  Europe PubMed DOI  I
2009
37. Koistinen,H., Koistinen,R., Zhang,W.M., Valmu,L. and Stenman,U.H.
    Nexin-1 inhibits the activity of human brain trypsin
    Neuroscience160, 97-102. PubMed  Europe PubMed DOI
2008
38. Salameh,M.A., Soares,A.S., Hockla,A. and Radisky,E.S.
    Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin
    J Biol Chem283, 4115-4123. PubMed  Europe PubMed DOI
39. Wang,Y., Luo,W. and Reiser,G.
    Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions
    Cell Mol Life Sci65, 237-252. PubMed  Europe PubMed DOI  V
2007
40. Knecht,W., Cottrell,G.S., Amadesi,S., Mohlin,J., Skaregarde,A., Gedda,K., Peterson,A., Chapman,K., Hollenberg,M.D., Vergnolle,N. and Bunnett,N.W.
    Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia
    J Biol Chem282, 26089-26100. PubMed  Europe PubMed DOI
41. Nemeth,A.L., Medveczky,P., Toth,J., Siklodi,E., Schlett,K., Patthy,A., Palkovits,M., Ovadi,J., Tokesi,N., Nemeth,P., Szilagyi,L. and Graf,L.
    Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine. A possible means to regulate gene expression
    FEBS J274, 1610-1620. PubMed  Europe PubMed DOI  R
42. Toth,J., Siklodi,E., Medveczky,P., Gallatz,K., Nemeth,P., Szilagyi,L., Graf,L. and Palkovits,M.
    Regional distribution of human trypsinogen 4 in human brain at mRNA and protein level
    Neurochem Res32, 1423-1433. PubMed  Europe PubMed DOI
43. Toth,J., Simon,Z., Medveczky,P., Gombos,L., Jelinek,B., Szilagyi,L., Graf,L. and Malnasi-Csizmadia,A.
    Site directed mutagenesis at position 193 of human trypsin 4 alters the rate of conformational change during activation: role of local internal viscosity in protein dynamics
    Proteins67, 1119-1127. PubMed  Europe PubMed DOI
2006
44. [YEAR:23-1-2006]Medveczky,P., Antal,J., Patthy,A., Kekesi,K., Juhasz,G., Szilagyi,L. and Graf,L.
    Myelin basic protein, an autoantigen in multiple sclerosis, is selectively processed by human trypsin 4
    FEBS Lett580, 545-552. PubMed  Europe PubMed DOI
45. [YEAR:5-6-2006]Szepessy,E. and Sahin-Toth,M.
    Human mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chains
    FEBS J273, 2942-2954. PubMed  Europe PubMed DOI  P
46. [YEAR:21-2-2006]Toth,J., Gombos,L., Simon,Z., Medveczky,P., Szilagyi,L., Graf,L. and Malnasi-Csizmadia,A.
    Thermodynamic analysis reveals structural rearrangement during the acylation step in human trypsin 4 on 4-methylumbelliferyl 4-guanidinobenzoate substrate analogue
    J Biol Chem281, 12596-12602. PubMed  Europe PubMed DOI  I
47. [YEAR:11-8-2006]Wang,Y., Luo,W., Wartmann,T., Halangk,W., Sahin-Toth,M. and Reiser,G.
    Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes
    J Neurochem99, 759-769. PubMed  Europe PubMed DOI
2005
48. [YEAR:12-7-2005]Marsit,C.J., Okpukpara,C., Danaee,H. and Kelsey,K.T.
    Epigenetic silencing of the PRSS3 putative tumor suppressor gene in non-small cell lung cancer
    Mol Carcinog44, 146-150. PubMed  Europe PubMed DOI
49. Rowen,L., Williams,E., Glusman,G., Linardopoulou,E., Friedman,C., Ahearn,M.E., Seto,J., Boysen,C., Qin,S., Wang,K., Kaur,A., Bloom,S., Hood,L. and Trask,B.J.
    Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogen
    Mol Biol Evol22, 1712-1720. PubMed  Europe PubMed DOI
50. Sahin-Toth,M.
    Human mesotrypsin defies natural trypsin inhibitors: from passive resistance to active destruction
    Protein Pept Lett12, 457-464. PubMed  Europe PubMed DOI
2004
51. Chen,J.M. and Ferec,C.
    Human trypsins
    [ISSN:0-12-079610-4]2, 1489-1493.  V
52. [YEAR:15-1-2004]Cottrell,G.S., Amadesi,S., Grady,E.F. and Bunnett,N.W.
    Trypsin IV, a novel agonist of protease-activated receptors 2 and 4
    J Biol Chem279, 13532-13539. PubMed  Europe PubMed DOI
2003
53. Szmola,R., Kukor,Z. and Sahin-Toth,M.
    Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors
    J Biol Chem278, 48580-48589. PubMed  Europe PubMed DOI  P
2002
54. [YEAR:1-2-2002]Katona,G., Berglund,G.I., Hajdu,J., Graf,L. and Szilagyi,L.
    Crystal structure reveals basis for the inhibitor resistance of human brain trypsin
    J Mol Biol315, 1209-1218. PubMed  Europe PubMed DOI  S  I
2000
55. Chen,J.M. and Ferec,C.
    Genes, cloned cDNAs, and proteins of human trypsinogens and pancreatitis-associated cationic trypsinogen mutations
    Pancreas21, 57-62. PubMed  Europe PubMed DOI
1998
56. Minn,A., Schubert,M., Neiss,W.F. and Muller-Hill,B.
    Enhanced GFAP expression in astrocytes of transgenic mice expressing the human brain-specific trypsinogen IV
    Glia22, 338-347. PubMed  Europe PubMed DOI
1997
57. Nyaruhucha,C.N., Kito,M. and Fukuoka,S.I.
    Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance
    J Biol Chem272, 10573-10578. PubMed  Europe PubMed DOI
1993
58. [YEAR:22-12-1993]Wiegand,U., Corbach,S., Minn,A., Kang,J. and Muller-Hill,B.
    Cloning of the cDNA encoding human brain trypsinogen and characterization of its product
    Gene136, 167-175. PubMed  Europe PubMed DOI
1990
59. Tani,T., Kawashima,I., Mita,K. and Takiguchi,Y.
    Nucleotide sequence of the human pancreatic trypsinogen III cDNA
    Nucleic Acids Res18, 1631-1631. PubMed  Europe PubMed
1984
60. Rinderknecht,H., Renner,I.G., Abramson,S.B. and Carmack,C.
    Mesotrypsin: a new inhibitor-resistant protease from a zymogen in human pancreatic tissue and fluid
    Gastroenterology86, 681-692. PubMed  Europe PubMed  I