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Literature for peptidase S01.174: mesotrypsin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, T Target, R Splicing, I Inhibitor, P Specificity, L Localization, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. David,M., Faihy,A., Rolland,C., Edir,A., Canivet,A., Ligat,L., Sebbag,M., Vergnolle,N., Olichon,A. and Deraison,C.
    Bispecific nanobody(R) as a new pharmacological drug for the selective inhibition of Trypsin-3
    Br J Pharmacol (2025) PubMed  Europe PubMed DOI
  2. Nie,L., Zhang,X. and Wu,J.
    PRSS3 is a potential prognostic biomarker for lung adenocarcinoma
    Transl Cancer Res (2025) 14, 1124-1140. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Pang,M., Xu,H., Li,D., Zhang,M., Chen,D., Tian,R., Gu,J., Alimu,N., Wang,E., Zhou,Z., Li,X., Peng,Q., He,Y., Lin,S., Guo,M. and Huang,J.
    CpG Methylation-Driven Pleiotropic Spliced Isoforms of PRSS3 Facilitate Gastric Intratumor Heterogeneity and Metastasis
    Cancer Sci (2025) PubMed  Europe PubMed DOI
    4. 2024
  4. Moreau,T., Recoules,E., De Pauw,M., Labas,V. and Rehault-Godbert,S.
    Evidence that the Bowman-Birk inhibitor from Pisum sativum affects intestinal proteolytic activities in chickens
    Poult Sci (2024) 103, 103182-103182. PubMed  Europe PubMed DOI  PMC  EPMC  L
    5. 2023
  5. Sananes,A., Cohen,I., Allon,I., Ben-David,O., Abu Shareb,R., Yegodayev,K.M., Stepensky,D., Elkabets,M. and Papo,N.
    Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers
    Mol Oncol (2023) 17, 2337-2355. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2022
  6. Koistinen,H., Koistinen,R., Hotakainen,K., Lempiainen,A., Jokelainen,K., Farkkila,M. and Stenman,U.H.
    Immunoassay for trypsinogen-4
    Anal Biochem (2022) 648, 114681-114681. PubMed  Europe PubMed DOI
  7. Rattanakomol,P., Srimanote,P., Tongtawe,P., Khantisitthiporn,O., Supasorn,O. and Thanongsaksrikul,J.
    Host neuronal PRSS3 interacts with enterovirus A71 3A protein and its role in viral replication
    Sci Rep (2022) 12, 12846-12846. PubMed  Europe PubMed DOI  PMC  EPMC
    8. 2021
  8. Zhang,Q., Wang,J., Huang,D. and Liu,G.
    High Expression of PRSS3 Indicates Unfavorable Clinical Outcomes in Colon Adenocarcinoma
    Appl Immunohistochem Mol Morphol (2021) 29, 564-569. PubMed  Europe PubMed DOI
    9. 2020
  9. Ramesh,K., Matta,S.A., Chew,F.T. and Mok,Y.K.
    Exonic mutations associated with atopic dermatitis disrupt lympho-epithelial Kazal-type related inhibitor action and enhance its degradation
    Allergy (2020) 75, 403-411. PubMed  Europe PubMed DOI
  10. Toldi,V., Szabo,A. and Sahin-Toth,M.
    Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation
    J Biol Chem (2020) 295, 3447-3455. PubMed  Europe PubMed DOI
    11. 2019
  11. Cohen,I., Coban,M., Shahar,A., Sankaran,B., Hockla,A., Lacham,S., Caulfield,T.R., Radisky,E.S. and Papo,N.
    Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin
    J Biol Chem (2019) 294, 5105-5120. PubMed  Europe PubMed DOI  S
    12. 2018
  12. Cohen,I., Naftaly,S., Ben-Zeev,E., Hockla,A., Radisky,E.S. and Papo,N.
    Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases
    Biochem J (2018) 475, 1335-1352. PubMed  Europe PubMed DOI
  13. de Veer,S.J., Li,C.Y., Swedberg,J.E., Schroeder,C.I. and Craik,D.J.
    Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1
    Eur J Med Chem (2018) 155, 695-704. PubMed  Europe PubMed DOI
  14. Schilling,O., Biniossek,M.L., Mayer,B., Elsasser,B., Brandstetter,H., Goettig,P., Stenman,U.H. and Koistinen,H.
    Specificity profiling of human trypsin-isoenzymes
    Biol Chem (2018) 399, 997-1007. PubMed  Europe PubMed DOI  P
    15. 2017
  15. Kayode,O., Huang,Z., Soares,A.S., Caulfield,T.R., Dong,Z., Bode,A.M. and Radisky,E.S.
    Small molecule inhibitors of mesotrypsin from a structure-based docking screen
    PLoS ONE (2017) 12, e0176694-e0176694. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
    16. 2016
  16. Cohen,I., Kayode,O., Hockla,A., Sankaran,B., Radisky,D.C., Radisky,E.S. and Papo,N.
    Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy
    Biochem J (2016) 473, 1329-1341. PubMed  Europe PubMed DOI
  17. Kayode,O., Wang,R., Pendlebury,D.F., Cohen,I., Henin,R.D., Hockla,A., Soares,A.S., Papo,N., Caulfield,T.R. and Radisky,E.S.
    An acrobatic substrate metamorphosis reveals a requirement for substrate conformational dynamics in trypsin proteolysis
    J Biol Chem (2016) 291, 26304-26319. PubMed  Europe PubMed DOI  PMC  EPMC  S
    18. 2015
  18. Alloy,A.P., Kayode,O., Wang,R., Hockla,A., Soares,A.S. and Radisky,E.S.
    Mesotrypsin has evolved four unique residues to cleave trypsin inhibitors as substrates
    J Biol Chem (2015) 290, 21523-21535. PubMed  Europe PubMed DOI
  19. Ghilardi,C., Silini,A., Figini,S., Anastasia,A., Lupi,M., Fruscio,R., Giavazzi,R. and Bani,M.R.
    Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2
    Oncotarget (2015) 6, 28389-28400. PubMed  Europe PubMed DOI
  20. Szabo,A., Ludwig,M., Hegyi,E., Szepeova,R., Witt,H. and Sahin-Toth,M.
    Mesotrypsin signature mutation in a chymotrypsin C (CTRC) variant associated with chronic pancreatitis
    J Biol Chem (2015) 290, 17282-17292. PubMed  Europe PubMed DOI
    21. 2014
  21. Haerteis,S., Krappitz,A., Krappitz,M., Murphy,J.E., Bertog,M., Krueger,B., Nacken,R., Chung,H., Hollenberg,M.D., Knecht,W., Bunnett,N.W. and Korbmacher,C.
    Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites
    J Biol Chem (2014) 289, 19067-19078. PubMed  Europe PubMed DOI  P
  22. Miyai,M., Matsumoto,Y., Yamanishi,H., Yamamoto-Tanaka,M., Tsuboi,R. and Hibino,T.
    Keratinocyte-specific mesotrypsin contributes to the desquamation process via kallikrein activation and LEKTI degradation
    J Invest Dermatol (2014) 134, 1665-1674. PubMed  Europe PubMed DOI
  23. Pendlebury,D., Wang,R., Henin,R.D., Hockla,A., Soares,A.S., Madden,B.J., Kazanov,M.D. and Radisky,E.S.
    Sequence and conformational specificity in substrate recognition: several human Kunitz protease inhibitor domains are specific substrates of mesotrypsin
    J Biol Chem (2014) 289, 32783-32797. PubMed  Europe PubMed DOI
  24. Yamamoto-Tanaka,M., Motoyama,A., Miyai,M., Matsunaga,Y., Matsuda,J., Tsuboi,R. and Hibino,T.
    Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation
    J Biol Chem (2014) 289, 20026-20038. PubMed  Europe PubMed DOI
    25. 2013
  25. Han,S., Lee,C.W., Trevino,J.G., Hughes,S.J. and Sarosi,G.A., Jr.
    Autocrine extra-pancreatic trypsin 3 secretion promotes cell proliferation and survival in esophageal adenocarcinoma
    PLoS ONE (2013) 8, e76667-e76667. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Salameh,M.A. and Radisky,E.S.
    Biochemical and structural insights into mesotrypsin: an unusual human trypsin
    Intl J Biochem Mol Biol (2013) 4, 129-139. PubMed  Europe PubMed  V
    27. 2012
  27. Chen,J.M., Radisky,E.S. and Ferec,C.
    Human trypsins
    [ISSN:978-0-12-407742-3] (2012) 3, 2600-2609. DOI
  28. Dhakal,B.K. and Mulvey,M.A.
    The UPEC pore-forming toxin alpha-hemolysin triggers proteolysis of host proteins to disrupt cell adhesion, inflammatory, and survival pathways
    Cell Host Microbe (2012) 11, 58-69. PubMed  Europe PubMed DOI  PMC  EPMC
  29. Hockla,A., Miller,E., Salameh,M.A., Copland,J.A., Radisky,D.C. and Radisky,E.S.
    PRSS3/mesotrypsin is a therapeutic target for metastatic prostate cancer
    Mol Cancer Res (2012) 10, 1555-1566. PubMed  Europe PubMed DOI  T
  30. Karle,M., Knecht,W. and Xue,Y.
    Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV
    Bioorg Med Chem Lett (2012) 22, 4839-4843. PubMed  Europe PubMed DOI  I
  31. Petronella,N. and Drouin,G.
    Strong purifying selection against gene conversions in the trypsin genes of primates
    Hum Genet (2012) 131, 1739-1749. PubMed  Europe PubMed DOI
  32. Salameh,M.A., Soares,A.S., Alloy,A. and Radisky,E.S.
    Presence versus absence of hydrogen bond donor Tyr-39 influences interactions of cationic trypsin and mesotrypsin with protein protease inhibitors
    Protein Sci (2012) 21, 1103-1112. PubMed  Europe PubMed DOI  S
    33. 2011
  33. Ceppa,E.P., Lyo,V., Grady,E.F., Knecht,W., Grahn,S., Peterson,A., Bunnett,N.W., Kirkwood,K.S. and Cattaruzza,F.
    Serine proteases mediate inflammatory pain in acute pancreatitis
    Am J Physiol Gastrointest Liver Physiol (2011) 300, G1033-G1042. PubMed  Europe PubMed DOI  T
  34. Salameh,M.A., Soares,A.S., Hockla,A., Radisky,D.C. and Radisky,E.S.
    The P(2)' residue is a key determinant of mesotrypsin specificity: engineering a high-affinity inhibitor with anticancer activity
    Biochem J (2011) 440, 95-105. PubMed  Europe PubMed DOI  P
    35. 2010
  35. Hockla,A., Radisky,D.C. and Radisky,E.S.
    Mesotrypsin promotes malignant growth of breast cancer cells through shedding of CD109
    Breast Cancer Res Treat (2010) 124, 27-38. PubMed  Europe PubMed DOI
  36. Salameh,M.A., Robinson,J.L., Navaneetham,D., Sinha,D., Madden,B.J., Walsh,P.N. and Radisky,E.S.
    The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin
    J Biol Chem (2010) 285, 1939-1949. PubMed  Europe PubMed DOI  P
  37. Salameh,M.A., Soares,A.S., Navaneetham,D., Sinha,D., Walsh,P.N. and Radisky,E.S.
    Determinants of affinity and proteolytic stability in interactions of Kunitz family protease inhibitors with mesotrypsin
    J Biol Chem (2010) 285, 36884-36896. PubMed  Europe PubMed DOI
  38. Wu,P., Weisell,J., Pakkala,M., Perakyla,M., Zhu,L., Koistinen,R., Koivunen,E., Stenman,U.H., Narvanen,A. and Koistinen,H.
    Identification of novel peptide inhibitors for human trypsins
    Biol Chem (2010) 391, 283-293. PubMed  Europe PubMed DOI  I
    39. 2009
  39. Koistinen,H., Koistinen,R., Zhang,W.M., Valmu,L. and Stenman,U.H.
    Nexin-1 inhibits the activity of human brain trypsin
    Neuroscience (2009) 160, 97-102. PubMed  Europe PubMed DOI
    40. 2008
  40. Salameh,M.A., Soares,A.S., Hockla,A. and Radisky,E.S.
    Structural basis for accelerated cleavage of bovine pancreatic trypsin inhibitor (BPTI) by human mesotrypsin
    J Biol Chem (2008) 283, 4115-4123. PubMed  Europe PubMed DOI
  41. Wang,Y., Luo,W. and Reiser,G.
    Trypsin and trypsin-like proteases in the brain: proteolysis and cellular functions
    Cell Mol Life Sci (2008) 65, 237-252. PubMed  Europe PubMed DOI  V
    42. 2007
  42. Knecht,W., Cottrell,G.S., Amadesi,S., Mohlin,J., Skaregarde,A., Gedda,K., Peterson,A., Chapman,K., Hollenberg,M.D., Vergnolle,N. and Bunnett,N.W.
    Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia
    J Biol Chem (2007) 282, 26089-26100. PubMed  Europe PubMed DOI
  43. Nemeth,A.L., Medveczky,P., Toth,J., Siklodi,E., Schlett,K., Patthy,A., Palkovits,M., Ovadi,J., Tokesi,N., Nemeth,P., Szilagyi,L. and Graf,L.
    Unconventional translation initiation of human trypsinogen 4 at a CUG codon with an N-terminal leucine. A possible means to regulate gene expression
    FEBS J (2007) 274, 1610-1620. PubMed  Europe PubMed DOI  R
  44. Toth,J., Simon,Z., Medveczky,P., Gombos,L., Jelinek,B., Szilagyi,L., Graf,L. and Malnasi-Csizmadia,A.
    Site directed mutagenesis at position 193 of human trypsin 4 alters the rate of conformational change during activation: role of local internal viscosity in protein dynamics
    Proteins (2007) 67, 1119-1127. PubMed  Europe PubMed DOI
  45. Toth,J., Siklodi,E., Medveczky,P., Gallatz,K., Nemeth,P., Szilagyi,L., Graf,L. and Palkovits,M.
    Regional distribution of human trypsinogen 4 in human brain at mRNA and protein level
    Neurochem Res (2007) 32, 1423-1433. PubMed  Europe PubMed DOI
    46. 2006
  46. [YEAR:23-1-2006]Medveczky,P., Antal,J., Patthy,A., Kekesi,K., Juhasz,G., Szilagyi,L. and Graf,L.
    Myelin basic protein, an autoantigen in multiple sclerosis, is selectively processed by human trypsin 4
    FEBS Lett (23-1-2006) 580, 545-552. PubMed  Europe PubMed DOI
  47. [YEAR:5-6-2006]Szepessy,E. and Sahin-Toth,M.
    Human mesotrypsin exhibits restricted S1' subsite specificity with a strong preference for small polar side chains
    FEBS J (5-6-2006) 273, 2942-2954. PubMed  Europe PubMed DOI  PMC  EPMC  P
  48. [YEAR:21-2-2006]Toth,J., Gombos,L., Simon,Z., Medveczky,P., Szilagyi,L., Graf,L. and Malnasi-Csizmadia,A.
    Thermodynamic analysis reveals structural rearrangement during the acylation step in human trypsin 4 on 4-methylumbelliferyl 4-guanidinobenzoate substrate analogue
    J Biol Chem (21-2-2006) 281, 12596-12602. PubMed  Europe PubMed DOI  I
  49. [YEAR:11-8-2006]Wang,Y., Luo,W., Wartmann,T., Halangk,W., Sahin-Toth,M. and Reiser,G.
    Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes
    J Neurochem (11-8-2006) 99, 759-769. PubMed  Europe PubMed DOI
    50. 2005
  50. [YEAR:12-7-2005]Marsit,C.J., Okpukpara,C., Danaee,H. and Kelsey,K.T.
    Epigenetic silencing of the PRSS3 putative tumor suppressor gene in non-small cell lung cancer
    Mol Carcinog (12-7-2005) 44, 146-150. PubMed  Europe PubMed DOI
  51. Rowen,L., Williams,E., Glusman,G., Linardopoulou,E., Friedman,C., Ahearn,M.E., Seto,J., Boysen,C., Qin,S., Wang,K., Kaur,A., Bloom,S., Hood,L. and Trask,B.J.
    Interchromosomal segmental duplications explain the unusual structure of PRSS3, the gene for an inhibitor-resistant trypsinogen
    Mol Biol Evol (2005) 22, 1712-1720. PubMed  Europe PubMed DOI
  52. Sahin-Toth,M.
    Human mesotrypsin defies natural trypsin inhibitors: from passive resistance to active destruction
    Protein Pept Lett (2005) 12, 457-464. PubMed  Europe PubMed DOI  PMC  EPMC
    53. 2004
  53. Chen,J.M. and Ferec,C.
    Human trypsins
    [ISSN:0-12-079610-4] (2004) 2, 1489-1493.  V
  54. [YEAR:15-1-2004]Cottrell,G.S., Amadesi,S., Grady,E.F. and Bunnett,N.W.
    Trypsin IV, a novel agonist of protease-activated receptors 2 and 4
    J Biol Chem (15-1-2004) 279, 13532-13539. PubMed  Europe PubMed DOI
    55. 2003
  55. Szmola,R., Kukor,Z. and Sahin-Toth,M.
    Human mesotrypsin is a unique digestive protease specialized for the degradation of trypsin inhibitors
    J Biol Chem (2003) 278, 48580-48589. PubMed  Europe PubMed DOI  PMC  EPMC  P
    56. 2002
  56. [YEAR:1-2-2002]Katona,G., Berglund,G.I., Hajdu,J., Graf,L. and Szilagyi,L.
    Crystal structure reveals basis for the inhibitor resistance of human brain trypsin
    J Mol Biol (1-2-2002) 315, 1209-1218. PubMed  Europe PubMed DOI  S  I
    57. 2000
  57. Chen,J.M. and Ferec,C.
    Genes, cloned cDNAs, and proteins of human trypsinogens and pancreatitis-associated cationic trypsinogen mutations
    Pancreas (2000) 21, 57-62. PubMed  Europe PubMed DOI
    58. 1998
  58. Minn,A., Schubert,M., Neiss,W.F. and Muller-Hill,B.
    Enhanced GFAP expression in astrocytes of transgenic mice expressing the human brain-specific trypsinogen IV
    Glia (1998) 22, 338-347. PubMed  Europe PubMed DOI
    59. 1997
  59. Nyaruhucha,C.N., Kito,M. and Fukuoka,S.I.
    Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance
    J Biol Chem (1997) 272, 10573-10578. PubMed  Europe PubMed DOI
    60. 1993
  60. [YEAR:22-12-1993]Wiegand,U., Corbach,S., Minn,A., Kang,J. and Muller-Hill,B.
    Cloning of the cDNA encoding human brain trypsinogen and characterization of its product
    Gene (22-12-1993) 136, 167-175. PubMed  Europe PubMed DOI
    61. 1990
  61. Tani,T., Kawashima,I., Mita,K. and Takiguchi,Y.
    Nucleotide sequence of the human pancreatic trypsinogen III cDNA
    Nucleic Acids Res (1990) 18, 1631-1631. PubMed  Europe PubMed  PMC  EPMC
    62. 1984
  62. Rinderknecht,H., Renner,I.G., Abramson,S.B. and Carmack,C.
    Mesotrypsin: a new inhibitor-resistant protease from a zymogen in human pancreatic tissue and fluid
    Gastroenterology (1984) 86, 681-692. PubMed  Europe PubMed  I

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