$VAR1 = undef;

Summary for peptidase S01.134: myeloblastin

Names
MEROPS Name	myeloblastin
Other names	AGP7, c-ANCA, neutrophil leukocyte proteinase 3, neutrophil leukocyte proteinase 4, p29b, PR3, proteinase 3, PRTN3 g.p. (Homo sapiens), Wegener’s granulomatosis autoantigen

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.134
Holotype	myeloblastin (Homo sapiens), Uniprot accession P24158 (peptidase unit: 28-250), MERNUM MER0000170
History	Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.

Activity
Catalytic type	Serine
Peplist	Included in the Peplist with identifier PL00272
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.21 (Serine endopeptidases) >> Peptidase 3.4.21.76
Enzymology	BRENDA database
Proteolytic events	CutDB database (18 cleavages)
Activity status	human: active (Rao & Hoidal, 2004) mouse: active (Jenne et al., 1997)
Physiology	Probable role in killing and digestion of bacteria by leukocytes. Involvement in growth and differentiation of human leukemic cells.
Pharmaceutical relevance	The antigen against which the autoimmunity of Wegener"s granulomatosis is directed. A major target of autoimmune reactions triggered by hepatitis C virus infection (Wu et al., 2002).
Other databases	TREEFAM	http://www.treefam.org/family/TF335284
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/y/-/vta-/-/-/- (based on 55 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	4	0	3	0	2	4	4	2
Pro	0	0	6	2	0	1	1	6
Ala	5	4	0	7	1	2	1	2
Val	2	4	2	14	5	1	1	3
Leu	6	4	5	1	3	7	4	3
Ile	1	1	0	0	1	2	3	5
Met	0	0	1	0	1	0	1	0
Phe	4	2	3	1	3	3	2	2
Tyr	6	15	13	0	0	1	2	3
Trp	0	0	0	0	0	1	0	1
Ser	5	6	3	2	9	4	6	2
Thr	3	4	6	8	5	3	1	2
Cys	0	0	1	3	0	0	0	1
Asn	0	1	2	0	1	1	3	0
Gln	0	0	1	0	0	4	4	0
Asp	0	0	2	1	1	5	1	2
Glu	0	1	5	0	3	2	3	2
Lys	3	3	0	4	0	1	2	1
Arg	2	4	0	1	3	4	1	3
His	0	4	1	0	2	2	0	0