Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P10147

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
23	unknown peptidase	1-92	P	release of a signal peptide	NT	Hunter et al., 1995
26	unknown peptidase	1-92	P		NT	<%Agarwal et al., 2012[]%>
35	cathepsin G	24-92	P		MS	Ryu et al., 2005
37	cathepsin G	24-92	P		MS	Ryu et al., 2005
38	elastase-2	24-92	P		MS	Ryu et al., 2005
38	myeloblastin	24-92	P		MS	Ryu et al., 2005
39	elastase-2	24-92	P		MS	Ryu et al., 2005
39	myeloblastin	24-92	P		MS	Ryu et al., 2005
46	cathepsin G	24-92	P		MS	Ryu et al., 2005
49	caspase-1	24-92	N		MS	Agard et al., 2010
50	cathepsin G	24-92	P		MS	Ryu et al., 2005
53	elastase-2	24-92	P		MS	Ryu et al., 2005
53	myeloblastin	24-92	P		MS	Ryu et al., 2005
75	cathepsin G	24-92	P		MS	Ryu et al., 2005
84	cathepsin G	24-92	P		MS	Ryu et al., 2005