Literature for peptidase S01.134: myeloblastin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Balmaceda,J.L., Rodriguez,L., Correa-Jimenez,O., Alfaro-Murillo,A., Buendia,E. and Munera,M. Proteinase-3 as an autoantigen and the development of granulomatosis with polyangiitis Allergol Immunopathol (Madr) (2025) 53, 143-153. PubMed Europe PubMed DOI
Jerke,U., Eulenberg-Gustavus,C., Wagner,D.L., Schreiber,A. and Kettritz,R. CRISPR-Cas9 mediated proteinase 3 autoantigen deletion as a treatment strategy for anti-neutrophil cytoplasmic autoantibody-associated vasculitis Kidney Int (2025) PubMed Europe PubMed DOI
Kahler,J.P., Coene,J., Skorenski,M., Korovesis,D. and Verhelst,S.H.L. Mixed Alkyl Aryl Phosphonates as Quenched Activity-Based Probes for Real-Time Imaging of Active Neutrophil Serine Proteases ACS Chem Biol (2025) PubMed Europe PubMed DOI
Korba-Mikolajczyk,A., Sluzalska,K.D. and Kasperkiewicz,P. Exploring the involvement of serine proteases in neutrophil extracellular traps: a review of mechanisms and implications Cell Death Dis (2025) 16, 535-535. PubMed Europe PubMed DOI PMC EPMC
Wroblewska-Schmude,A., Audzeyenka,I., Mallek,W., Wysocka,M., Lesner,A., Narajczyk,M., Gajdowska,F., Gutowska-Owsiak,D., Kulesza,T., Rogacka,D. and Piwkowska,A. Podocytes as novel sources of neutrophil serine proteases: expression and regulation by inflammatory molecular patterns Cell Mol Life Sci (2025) PubMed Europe PubMed DOI

2024

Gartan,P., Khorsand,F., Mizar,P., Vahokovski,J.I., Cervantes,L.F., Haug,B.E., Brenk,R., Brooks,C.L., III and Reuter,N. Investigating Polypharmacology through Targeting Known Human Neutrophil Elastase Inhibitors to Proteinase 3 J Chem Inf Model (2024) 64, 621-626. PubMed Europe PubMed DOI PMC EPMC
Hwang,T.L., Lin,J.Y., Kuo,L.M., Kumar Dhandabani,G. and Hsieh,P.W. Design and synthesis of sirtinol analogs as human neutrophil elastase inhibitors Bioorg Med Chem Lett (2024) 97, 129544-129544. PubMed Europe PubMed DOI I
Khorsand,F., Haug,B.E., Kursula,I., Reuter,N. and Brenk,R. Expression and purification of human neutrophil proteinase 3 from insect cells and characterization of ligand binding PLoS ONE (2024) 19, e0294827-e0294827. PubMed Europe PubMed DOI PMC EPMC
Zhu,H.Y., Wang,H.J. and Liu,P. Versatile roles for neutrophil proteinase 3 in hematopoiesis and inflammation Immunol Res (2024) 73, 1-1. PubMed Europe PubMed DOI

2022

Basso,J., Zhang,J., Lasala,D., Rose,S.J., Chen,K.J. and Cipolla,D. An optimized method of extracting and quantifying active Neutrophil serine proteases from human whole blood cells PLoS ONE (2022) 17, e0272575-e0272575. PubMed Europe PubMed DOI PMC EPMC
Gomez-Alonso,I.S., Martinez-Garcia,S., Betanzos-Cabrera,G., Juarez,E., Sarabia-Leon,M.C., Herrera,M.T., Gomez-Chavez,F., Sanchez-Torres,L., Rodriguez-Martinez,S., Cancino-Diaz,M.E., Cancino,J. and Cancino-Diaz,J.C. Low Concentration of the Neutrophil Proteases Cathepsin G, Cathepsin B, Proteinase-3 and Metalloproteinase-9 Induce Biofilm Formation in Non-Biofilm-Forming Staphylococcus epidermidis Isolates Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Marino,S.F., Jerke,U., Rolle,S., Daumke,O. and Kettritz,R. Competitively disrupting the neutrophil-specific receptor-autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation J Biol Chem (2022) 298, 101598-101598. PubMed Europe PubMed DOI PMC EPMC
Nguyen,S.D., Maaninka,K., Mayranpaa,M.I., Baumann,M., Soliymani,R., Lee-Rueckert,M., Jauhiainen,M., Kovanen,P.T. and Oorni,K. Neutrophil proteinase 3 - An LDL- and HDL-proteolyzing enzyme with a potential to contribute to cholesterol accumulation in human atherosclerotic lesions Biochim Biophys Acta Mol Cell Biol Lipids (2022) 1867, 159225-159225. PubMed Europe PubMed DOI

2021

Cheung,P., Schaffert,S., Chang,S.E., Dvorak,M., Donato,M., Macaubas,C., Foecke,M.H., Li,T.M., Zhang,L., Coan,J.P., Schulert,G.S., Grom,A.A., Henderson,L.A., Nigrovic,P.A., Elias,J.E., Gozani,O., Mellins,E.D., Khatri,P., Utz,P.J. and Kuo,A.J. Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation Nat Immunol (2021) 22, 711-722. PubMed Europe PubMed DOI PMC EPMC
Fazleen,A. and Wilkinson,T. The emerging role of proteases in alpha1-antitrypsin deficiency and beyond ERJ Open Res (2021) 7 PubMed Europe PubMed DOI PMC EPMC
Mustafa,Z., Zhanapiya,A., Kalbacher,H. and Burster,T. Neutrophil Elastase and Proteinase 3 Cleavage Sites Are Adjacent to the Polybasic Sequence within the Proteolytic Sensitive Activation Loop of the SARS-CoV-2 Spike Protein ACS Omega (2021) 6, 7181-7185. PubMed Europe PubMed DOI PMC EPMC
Patterson,E.K., Vanin Moreno,N., Fraser,D.D., Cepinskas,G., Iida,T. and Berard,R.A. A Proteinase 3 Contribution to Juvenile Idiopathic Arthritis-Associated Cartilage Damage Pathophysiology (2021) 28, 320-327. PubMed Europe PubMed DOI PMC EPMC
Weiss,S.A.I., Rehm,S.R.T., Perera,N.C., Biniossek,M.L., Schilling,O. and Jenne,D.E. Origin and Expansion of the Serine Protease Repertoire in the Myelomonocyte Lineage Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC
Yoshida,S., Hanai,S., Nakagomi,D., Kobayashi,K., Takahashi,K. and Furuya,F. Membranous Nephropathy with Proteinase 3-ANCA-associated Vasculitis Successfully Treated with Rituximab Intern Med (2021) 60, 145-150. PubMed Europe PubMed DOI

2020

Akgun,E., Tuzuner,M.B., Sahin,B., Kilercik,M., Kulah,C., Cakiroglu,H.N., Serteser,M., Unsal,I. and Baykal,A.T. Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patients PLoS ONE (2020) 15, e0240012-e0240012. PubMed Europe PubMed DOI PMC EPMC
Basu,K., Karmakar,S., Sengupta,M., Roychowdhury,A., Ghosh,A. and Bandopadhyay,M. Pediatric lupus nephritis - An evil cousin of its adult counterpart: A single-center based experience from a tertiary care hospital of Eastern India Indian J Pathol Microbiol (2020) 63, 397-404. PubMed Europe PubMed DOI
Fu,Z., Akula,S., Thorpe,M. and Hellman,L. Potent and broad but not unselective cleavage of cytokines and chemokines by human neutrophil elastase and proteinase 3 Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI
Moore,R.M., Katri,R., Kumar,D., Mansour,J.M., Mercer,B. and Moore,J.J. alpha-Lipoic acid blocks the GMCSF induced protease/protease inhibitor spectrum associated with fetal membrane weakening in-vitro Placenta (2020) 97, 79-88. PubMed Europe PubMed DOI
N'Guessan,K., Grzywa,R., Seren,S., Gabant,G., Juliano,M.A., Moniatte,M., Van Dorsselaer,A., Bieth,J., Kellenberger,C., Gauthier,F., Wysocka,M., Lesner,A., Sienczyk,M., Cadene,M. and Korkmaz,B. Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin FEBS J (2020) PubMed Europe PubMed DOI

2019

Grzywa,R., Lesner,A., Korkmaz,B. and Sienczyk,M. Proteinase 3 phosphonic inhibitors Biochimie (2019) 166, 142-149. PubMed Europe PubMed DOI I
Maximova,K., Reuter,N. and Trylska,J. Peptidomimetic inhibitors targeting the membrane-binding site of the neutrophil proteinase 3 Biochim Biophys Acta Biomembr (2019) 1861, 1502-1509. PubMed Europe PubMed DOI
Newby,P.R., Crossley,D., Crisford,H., Stockley,J.A., Mumford,R.A., Carter,R.I., Bolton,C.E., Hopkinson,N.S., Mahadeva,R., Steiner,M.C., Wilkinson,T.M.A., Sapey,E. and Stockley,R.A. A specific proteinase 3 activity footprint in alpha1-antitrypsin deficiency ERJ Open Res (2019) 5 PubMed Europe PubMed DOI PMC EPMC
Tian,S., Swedberg,J.E., Li,C.Y., Craik,D.J. and de Veer,S.J. Iterative optimization of the cyclic peptide SFTI-1 yields potent inhibitors of neutrophil proteinase 3 ACS Med Chem Lett (2019) 10, 1234-1239. PubMed Europe PubMed DOI PMC EPMC

2018

Fu,Z., Thorpe,M., Akula,S., Chahal,G. and Hellman,L.T. Extended cleavage specificity of human neutrophil elastase, human proteinase 3, and their distant ortholog clawed frog PR3-three elastases with similar primary but different extended specificities and stability Front Immunol (2018) 9, 2387-2387. PubMed Europe PubMed DOI PMC EPMC P
Guarino,C., Gruba,N., Grzywa,R., Dyguda-Kazimierowicz,E., Hamon,Y., Legowska,M., Skorenski,M., Dallet-Choisy,S., Marchand-Adam,S., Kellenberger,C., Jenne,D.E., Sienczyk,M., Lesner,A., Gauthier,F. and Korkmaz,B. Exploiting the S4-S5 specificity of human neutrophil proteinase 3 to improve the potency of peptidyl di(chlorophenyl)-phosphonate ester inhibitors: a kinetic and molecular modeling analysis J Med Chem (2018) 61, 1858-1870. PubMed Europe PubMed DOI I
Gudmann,N.S., Manon-Jensen,T., Sand,J.M.B., Diefenbach,C., Sun,S., Danielsen,A., Karsdal,M.A. and Leeming,D.J. Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease Biochem Biophys Res Commun (2018) 503, 1284-1290. PubMed Europe PubMed DOI
Popow-Stellmaszyk,J., Bajorowicz,B., Malankowska,A., Wysocka,M., Klimczuk,T., Zaleska-Medynska,A. and Lesner,A. Design, synthesis, and enzymatic evaluation of novel ZnO quantum dot-based assay for detection of proteinase 3 activity Bioconjug Chem (2018) 29, 1576-1583. PubMed Europe PubMed DOI A
Seren,S., Rashed Abouzaid,M., Eulenberg-Gustavus,C., Hirschfeld,J., Nasr Soliman,H., Jerke,U., N'Guessan,K., Dallet-Choisy,S., Lesner,A., Lauritzen,C., Schacher,B., Eickholz,P., Nagy,N., Szell,M., Croix,C., Viaud-Massuard,M.C., Al Farraj Aldosari,A., Ragunatha,S., Ibrahim Mostafa,M., Giampieri,F., Battino,M., Cornillier,H., Lorette,G., Stephan,J.L., Goizet,C., Pedersen,J., Gauthier,F., Jenne,D.E., Marchand-Adam,S., Chapple,I.L., Kettritz,R. and Korkmaz,B. Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis J Biol Chem (2018) 293, 12415-12428. PubMed Europe PubMed DOI
Tacnet-Delorme,P., Gabillet,J., Chatfield,S., Thieblemont,N., Frachet,P. and Witko-Sarsat,V. Proteinase 3 interferes with C1q-mediated clearance of apoptotic cells Front Immunol (2018) 9, 818-818. PubMed Europe PubMed DOI PMC EPMC
Witko-Sarsat,V. and Thieblemont,N. Granulomatosis with polyangiitis (Wegener granulomatosis): a proteinase-3 driven disease? Joint Bone Spine (2018) 85, 185-189. PubMed Europe PubMed DOI

2017

Benarafa,C. and Simon,H.U. Role of granule proteases in the life and death of neutrophils Biochem Biophys Res Commun (2017) 482, 473-481. PubMed Europe PubMed DOI V
Martin,K.R. and Witko-Sarsat,V. Proteinase 3: the odd one out that became an autoantigen J Leukoc Biol (2017) 102, 689-698. PubMed Europe PubMed DOI V
Maximova,K., Venken,T., Reuter,N. and Trylska,J. d-Peptides as inhibitors of PR3-membrane interactions Biochim Biophys Acta (2017) 1860, 458-466. PubMed Europe PubMed DOI
Witko-Sarsat,V. and Thieblemont,N. Granulomatosis with polyangiitis (Wegener): a proteinase 3-driven disease? Rev Rhum Monogr (2017) 84, 236-240. DOI

2016

Craciun,I., Fenner,A.M. and Kerns,R.J. N-Arylacyl O-sulfonated aminoglycosides as novel inhibitors of human neutrophil elastase, cathepsin G and proteinase 3 Glycobiology (2016) 26, 701-709. PubMed Europe PubMed DOI I
Kim,Y.C., Choi,Y.S., Alam,J., Kim,Y.J., Baek,K.J., Koh,J., Song,Y.W., Chung,D.H. and Choi,Y. Induction of proteinase 3-anti-neutrophil cytoplasmic autoantibodies by proteinase 3-homologous bacterial protease in mice Immunol Res (2016) 64, 438-444. PubMed Europe PubMed DOI
Korkmaz,B., Lesner,A., Guarino,C., Wysocka,M., Kellenberger,C., Watier,H., Specks,U., Gauthier,F. and Jenne,D.E. Inhibitors and antibody fragments as potential anti-inflammatory therapeutics targeting neutrophil proteinase 3 in human disease Pharmacol Rev (2016) 68, 603-630. PubMed Europe PubMed DOI V T
Martin,K.R., Kantari-Mimoun,C., Yin,M., Pederzoli-Ribeil,M., Angelot-Delettre,F., Ceroi,A., Grauffel,C., Benhamou,M., Reuter,N., Saas,P., Frachet,P., Boulanger,C.M. and Witko-Sarsat,V. Proteinase 3 is a phosphatidylserine-binding protein that affects the production and function of microvesicles J Biol Chem (2016) 291, 10476-10489. PubMed Europe PubMed DOI
Mkaouar,H., Akermi,N., Mariaule,V., Boudebbouze,S., Gaci,N., Szukala,F., Pons,N., Marquez,J., Gargouri,A., Maguin,E. and Rhimi,M. Siropins, novel serine protease inhibitors from gut microbiota acting on human proteases involved in inflammatory bowel diseases Microb Cell Fact (2016) 15, 201-201. PubMed Europe PubMed DOI PMC EPMC

2015

Hwang,T.L., Wang,W.H., Wang,T.Y., Yu,H.P. and Hsieh,P.W. Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3 Bioorg Med Chem (2015) 23, 1123-1134. PubMed Europe PubMed DOI I
Liu,G.-H., Deng,L. and Peng,L.-F. Research advances on proteinase 3 and its relationship with diseases Prog Biochem Biophys (2015) 42, 244-253. DOI V

2014

Budnjo,A., Narawane,S., Grauffel,C., Schillinger,A.S., Fossen,T., Reuter,N. and Haug,B.E. Reversible ketomethylene-based inhibitors of human neutrophil proteinase 3 J Med Chem (2014) 57, 9396-9408. PubMed Europe PubMed DOI I
Grzywa,R., Burchacka,E., Lecka,M., Winiarski,L., Walczak,M., Lupicka-Slowik,A., Wysocka,M., Burster,T., Bobrek,K., Csencsits-Smith,K., Lesner,A. and Sienczyk,M. Synthesis of novel phosphonic-type activity-based probes for neutrophil serine proteases and their application in spleen lysates of different organisms Chembiochem (2014) 15, 2605-2612. PubMed Europe PubMed DOI I
Guarino,C., Legowska,M., Epinette,C., Kellenberger,C., Dallet-Choisy,S., Sienczyk,M., Gabant,G., Cadene,M., Zoidakis,J., Vlahou,A., Wysocka,M., Marchand-Adam,S., Jenne,D.E., Lesner,A., Gauthier,F. and Korkmaz,B. New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases J Biol Chem (2014) 289, 31777-31791. PubMed Europe PubMed DOI P L I
Narawane,S., Budnjo,A., Grauffel,C., Haug,B.E. and Reuter,N. In silico design, synthesis, and assays of specific substrates for proteinase 3: influence of fluorogenic and charged groups J Med Chem (2014) 57, 1111-1115. PubMed Europe PubMed DOI A P
Schillinger,A.S., Grauffel,C., Khan,H.M., Halskau,O. and Reuter,N. Two homologous neutrophil serine proteases bind to POPC vesicles with different affinities: when aromatic amino acids matter Biochim Biophys Acta (2014) 1838, 3191-3202. PubMed Europe PubMed DOI
Stapels,D.A., Ramyar,K.X., Bischoff,M., von Kockritz-Blickwede,M., Milder,F.J., Ruyken,M., Eisenbeis,J., McWhorter,W.J., Herrmann,M., Van Kessel,K.P., Geisbrecht,B.V. and Rooijakkers,S.H. Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors Proc Natl Acad Sci U S A (2014) 111, 13187-13192. PubMed Europe PubMed DOI S

2013

Hinkofer,L.C., Seidel,S.A., Korkmaz,B., Silva,F., Hummel,A.M., Braun,D., Jenne,D.E. and Specks,U. A monoclonal antibody (MCPR3-7) interfering with the activity of proteinase 3 by an allosteric mechanism J Biol Chem (2013) 288, 26635-26648. PubMed Europe PubMed DOI
Korkmaz,B., Kellenberger,C., Viaud-Massuard,M.C. and Gauthier,F. Selective inhibitors of human neutrophil proteinase 3 Curr Pharm Des (2013) 19, 966-976. PubMed Europe PubMed I
Korkmaz,B., Jenne,D.E. and Gauthier,F. Relevance of the mouse model as a therapeutic approach for neutrophil proteinase 3-associated human diseases Int Immunopharmacol (2013) 17, 1198-1205. PubMed Europe PubMed DOI
Kuckleburg,C.J. and Newman,P.J. Neutrophil Proteinase 3 Acts on Protease-Activated Receptor-2 to Enhance Vascular Endothelial Cell Barrier Function Arterioscler Thromb Vasc Biol (2013) 33, 275-284. PubMed Europe PubMed DOI
Kwon,K.J., Cho,K.S., Kim,J.N., Kim,M.K., Lee,E.J., Kim,S.Y., Jeon,S.J., Kim,K.C., Han,J.E., Kang,Y.S., Kim,S., Kim,H.Y., Han,S.H., Bahn,G., Choi,J.W. and Shin,C.Y. Proteinase 3 induces oxidative stress-mediated neuronal death in rat primary cortical neuron Neurosci Lett (2013) 548, 67-72. PubMed Europe PubMed DOI
Popow-Stellmaszyk,J., Wysocka,M., Lesner,A., Korkmaz,B. and Rolka,K. A new proteinase 3 substrate with improved selectivity over human neutrophil elastase Anal Biochem (2013) 442, 75-82. PubMed Europe PubMed DOI A

2012

Bae,S., Choi,J., Hong,J., Jhun,H., Hong,K., Kang,T., Song,K., Jeong,S., Yum,H. and Kim,S. Neutrophil proteinase 3 induces diabetes in a mouse model of glucose tolerance Endocr Res (2012) 37, 35-45. PubMed Europe PubMed DOI
Bae,S., Kang,T., Hong,J., Lee,S., Choi,J., Jhun,H., Kwak,A., Hong,K., Kim,E., Jo,S. and Kim,S. Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity J Biol Chem (2012) 287, 8205-8213. PubMed Europe PubMed DOI
Brea,D., Meurens,F., Dubois,A.V., Gaillard,J., Chevaleyre,C., Jourdan,M.L., Winter,N., Arbeille,B., Si-Tahar,M., Gauthier,F. and Attucci,S. The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases Biochem J (2012) 447, 363-370. PubMed Europe PubMed DOI
Dubois,A.V., Gauthier,A., Brea,D., Varaigne,F., Diot,P., Gauthier,F. and Attucci,S. Influence of DNA on the activities and inhibition of neutrophil serine proteases in cystic fibrosis sputum Am J Respir Cell Mol Biol (2012) 47, 80-86. PubMed Europe PubMed DOI
Epinette,C., Croix,C., Jaquillard,L., Marchand-Adam,S., Kellenberger,C., Lalmanach,G., Cadene,M., Viaud-Massuard,M.C., Gauthier,F. and Korkmaz,B. A selective reversible azapeptide inhibitor of human neutrophil proteinase 3 derived from a high affinity FRET substrate Biochem Pharmacol (2012) 83, 788-796. PubMed Europe PubMed DOI I
Heinz,A., Jung,M.C., Jahreis,G., Rusciani,A., Duca,L., Debelle,L., Weiss,A.S., Neubert,R.H. and Schmelzer,C.E. The action of neutrophil serine proteases on elastin and its precursor Biochimie (2012) 94, 192-202. PubMed Europe PubMed DOI P
Korkmaz,B., Attucci,S., Epinette,C., Pitois,E., Jourdan,M.L., Juliano,L. and Gauthier,F. Measurement of neutrophil elastase, proteinase 3, and cathepsin G activities using intramolecularly quenched fluorogenic substrates Methods Mol Biol (2012) 844, 125-138. PubMed Europe PubMed DOI A
Kuckleburg,C.J., Tilkens,S.B., Santoso,S. and Newman,P.J. Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils J Immunol (2012) 188, 2419-2426. PubMed Europe PubMed DOI
Monleon,L.M., Diez-Garcia,F., Zamora,H., Anaya,J., Grande,M., De Diego,J.G. and David Rodriguez,F. In vitro evaluation of the antielastase activity of polycyclic beta-lactams Bioorg Chem (2012) 45, 29-35. PubMed Europe PubMed DOI I
Rao,N.V. and Hoidal,J.R. Myeloblastin [ISSN:978-0-12-407742-3] (2012) 3, 2666-2675. DOI
Wiedl,T., Collaud,S., Hillinger,S., Arni,S., Burgess,C., Kroll,W., Schraml,P., Soltermann,A., Moch,H. and Weder,W. KRAS Mutation is associated with elevated myeloblastin activity in human lung adenocarcinoma Cancer Genomics Proteomics (2012) 9, 51-54. PubMed Europe PubMed T
Wysocka,M., Lesner,A., Gruba,N., Korkmaz,B., Gauthier,F., Kitamatsu,M., Legowska,A. and Rolka,K. Three wavelength substrate system of neutrophil serine proteinases Anal Chem (2012) 84, 7241-7248. PubMed Europe PubMed DOI A
Wysocka,M., Lesner,A., Popow,J., Legowska,M. and Rolka,K. Pegylated fluorescent peptides as substrates of proteolytic enzymes Protein Pept Lett (2012) 19, 1237-1244. PubMed Europe PubMed A P

2011

Jegot,G., Derache,C., Castella,S., Lahouassa,H., Pitois,E., Jourdan,M.L., Remold-O'Donnell,E., Kellenberger,C., Gauthier,F. and Korkmaz,B. A substrate-based approach to convert serpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen FASEB J (2011) 25, 3019-3031. PubMed Europe PubMed DOI
Kessenbrock,K., Dau,T. and Jenne,D.E. Tailor-made inflammation: how neutrophil serine proteases modulate the inflammatory response J Mol Med (Berl) (2011) 89, 23-28. PubMed Europe PubMed DOI
Relle,M., Thomaidis,T., Galle,P.R. and Schwarting,A. Comparative aspects of murine proteinase 3 Rheumatol Int (2011) 31, 1105-1111. PubMed Europe PubMed DOI

2010

Bae,S., Choi,J., Hong,J., Lee,S., Her,E., Choi,W., Kim,S., Choi,Y. and Kim,S. Generation of anti-proteinase 3 monoclonal antibodies and development of immunological methods to detect endogenous proteinase 3 Hybridoma (Larchmt) (2010) 29, 17-26. PubMed Europe PubMed DOI
Broemstrup,T. and Reuter,N. How does proteinase 3 interact with lipid bilayers? Phys Chem Chem Phys (2010) 12, 7487-7496. PubMed Europe PubMed DOI
Dou,D., He,G., Li,Y., Lai,Z., Wei,L., Alliston,K.R., Lushington,G.H., Eichhorn,D.M. and Groutas,W.C. Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3 Bioorg Med Chem (2010) 18, 1093-1102. PubMed Europe PubMed DOI I
Dou,D., He,G., Kuang,R., Fu,Q., Venkataraman,R. and Groutas,W.C. Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase Bioorg Med Chem (2010) 18, 6646-6650. PubMed Europe PubMed DOI I
Hajjar,E., Broemstrup,T., Kantari,C., Witko-Sarsat,V. and Reuter,N. Structures of human proteinase 3 and neutrophil elastase - so similar yet so different FEBS J (2010) 277, 2238-2254. PubMed Europe PubMed DOI
Korkmaz,B., Horwitz,M.S., Jenne,D.E. and Gauthier,F. Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases Pharmacol Rev (2010) 62, 726-759. PubMed Europe PubMed DOI V T
Kuhl,A., Korkmaz,B., Utecht,B., Kniepert,A., Schonermarck,U., Specks,U. and Jenne,D.E. Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener's granulomatosis J Immunol (2010) 185, 387-399. PubMed Europe PubMed DOI
Pederzoli-Ribeil,M., Maione,F., Cooper,D., Al-Kashi,A., Dalli,J., Perretti,M. and D'Acquisto,F. Design and characterization of a cleavage-resistant annexin A1 mutant to control inflammation in the microvasculature Blood (2010) 116, 4288-4296. PubMed Europe PubMed DOI
Wysocka,M., Lesner,A., Majkowska,G., Legowska,A., Guzow,K., Rolka,K. and Wiczk,W. The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region Anal Biochem (2010) 399, 196-201. PubMed Europe PubMed DOI P
Wysocka,M., Lesner,A., Guzow,K., Kulczycka,J., Legowska,A., Wiczk,W. and Rolka,K. Highly specific substrates of proteinase 3 containing 3-(2-benzoxazol-5-yl)-l-alanine and their application for detection of this enzyme in human serum Anal Chem (2010) 82, 3883-3889. PubMed Europe PubMed DOI A P

2009

Hajjar,E., Dejaegere,A. and Reuter,N. Challenges in pKa predictions for proteins: the case of Asp213 in human proteinase 3 J Phys Chem A (2009) 113, 11783-11792. PubMed Europe PubMed DOI
Joosten,L.A., Netea,M.G., Fantuzzi,G., Koenders,M.I., Helsen,M.M., Sparrer,H., Pham,C.T., van der Meer,J.W., Dinarello,C.A. and van den Berg,W.B. Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta Arthritis Rheum (2009) 60, 3651-3662. PubMed Europe PubMed DOI
Kalupov,T., Brillard-Bourdet,M., Dade,S., Serrano,H., Wartelle,J., Guyot,N., Juliano,L., Moreau,T., Belaaouaj,A. and Gauthier,F. Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseases J Biol Chem (2009) 284, 34084-34091. PubMed Europe PubMed DOI P
Raife,T.J., Cao,W., Atkinson,B.S., Bedell,B., Montgomery,R.R., Lentz,S.R., Johnson,G.F. and Zheng,X.L. Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site Blood (2009) 114, 1666-1674. PubMed Europe PubMed DOI PMC EPMC P

2008

Hajjar,E., Mihajlovic,M., Witko-Sarsat,V., Lazaridis,T. and Reuter,N. Computational prediction of the binding site of proteinase 3 to the plasma membrane Proteins (2008) 71, 1655-1669. PubMed Europe PubMed DOI
Kim,S., Lee,S., Her,E., Bae,S., Choi,J., Hong,J., Jaekal,J., Yoon,D., Azam,T., Dinarello,C.A. and Kim,S. Proteinase 3-processed form of the recombinant IL-32 separate domain BMB Rep (2008) 41, 814-819. PubMed Europe PubMed P
Korkmaz,B., Moreau,T. and Gauthier,F. Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions Biochimie (2008) 90, 227-242. PubMed Europe PubMed DOI V
Korkmaz,B., Kuhl,A., Bayat,B., Santoso,S. and Jenne,D.E. A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors J Biol Chem (2008) 283, 35976-35982. PubMed Europe PubMed DOI
Wysocka,M., Lesner,A., Guzow,K., Mackiewicz,L., Legowska,A., Wiczk,W. and Rolka,K. Design of selective substrates of proteinase 3 using combinatorial chemistry methods Anal Biochem (2008) 378, 208-215. PubMed Europe PubMed DOI A P

2007

Farrag,L., Pendergraft,W.F., III, Yang,J.J., Jennette,J.C., Falk,R.J. and Preston,G.A. A study of conformational restraints on reactivity of human PR3-specific autoantibodies (ANCA) facilitated through protein folding manipulations of a new recombinant proteinase 3 protein Autoimmunity (2007) 40, 503-511. PubMed Europe PubMed DOI E
Hajjar,E., Korkmaz,B. and Reuter,N. Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase FEBS Lett (2007) 581, 5685-5690. PubMed Europe PubMed DOI P
Korkmaz,B., Hajjar,E., Kalupov,T., Reuter,N., Brillard-Bourdet,M., Moreau,T., Juliano,L. and Gauthier,F. Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase. A kinetic and molecular modeling analysis J Biol Chem (2007) 282, 1989-1997. PubMed Europe PubMed DOI P
Muller,A., Voswinkel,J., Gottschlich,S. and Csernok,E. Human proteinase 3 (PR3) and its binding molecules: implications for inflammatory and PR3-related autoimmune responses Ann N Y Acad Sci (2007) 1109, 84-92. PubMed Europe PubMed DOI
Specks,U., Fass,D.N., Finkielman,J.D., Hummel,A.M., Viss,M.A., Litwiller,R.D. and McDonald,C.J. Functional significance of Asn-linked glycosylation of proteinase 3 for enzymatic activity, processing, targeting, and recognition by anti-neutrophil cytoplasmic antibodies J Biochem (2007) 141, 101-112. PubMed Europe PubMed DOI

2006

[YEAR:6-10-2006]Armstrong,L., Godinho,S.I., Uppington,K.M., Whittington,H.A. and Millar,A.B. Contribution of TNF-alpha converting enzyme and proteinase-3 to TNF-alpha processing in human alveolar macrophages Am J Respir Cell Mol Biol (6-10-2006) 34, 219-225. PubMed Europe PubMed DOI
Hajjar,E., Korkmaz,B., Gauthier,F., Brandsdal,B.O., Witko-Sarsat,V. and Reuter,N. Inspection of the binding sites of proteinase3 for the design of a highly specific substrate J Med Chem (2006) 49, 1248-1260. PubMed Europe PubMed DOI
Jenne,D.E. and Kuhl,A. Production and applications of recombinant proteinase 3, Wegener's autoantigen: problems and perspectives Clin Nephrol (2006) 66, 153-159. PubMed Europe PubMed E
Novick,D., Rubinstein,M., Azam,T., Rabinkov,A., Dinarello,C.A. and Kim,S.H. Proteinase 3 is an IL-32 binding protein Proc Natl Acad Sci U S A (2006) 103, 3316-3321. PubMed Europe PubMed DOI PMC EPMC
Pham,C.T. Neutrophil serine proteases: specific regulators of inflammation Nat Rev Immunol (2006) 6, 541-550. PubMed Europe PubMed DOI V

2005

[YEAR:22-5-2005]David,A., Fridlich,R. and Aviram,I. The presence of membrane proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558 Exp Cell Res (22-5-2005) 308, 156-165. PubMed Europe PubMed DOI
[YEAR:22-2-2005]Ryu,O.H., Choi,S.J., Firatli,E., Choi,S.W., Hart,P.S., Shen,R.F., Wang,G., Wu,W.W. and Hart,T.C. Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases J Biol Chem (22-2-2005) 280, 17415-17421. PubMed Europe PubMed DOI P
Skold,S., Rosberg,B. and Olofsson,T. The N-terminal tetrapeptide of neutrophil proteinase 3 causes S-phase arrest in granulopoietic progenitors Exp Hematol (2005) 33, 1329-1336. PubMed Europe PubMed DOI
Sugawara,S. Immune functions of proteinase 3 Crit Rev Immunol (2005) 25, 343-360. PubMed Europe PubMed DOI V

2004

[YEAR:23-12-2004]Korkmaz,B., Attucci,S., Moreau,T., Godat,E., Juliano,L. and Gauthier,F. Design and use of highly specific substrates of neutrophil elastase and proteinase 3 Am J Respir Cell Mol Biol (23-12-2004) 30, 801-807. PubMed Europe PubMed DOI P
Pendergraft,W.F., III, Rudolph,E.H., Falk,R.J., Jahn,J.E., Grimmler,M., Hengst,L., Jennette,J.C. and Preston,G.A. Proteinase 3 sidesteps caspases and cleaves p21(Waf1/Cip1/Sdi1) to induce endothelial cell apoptosis Kidney Int (2004) 65, 75-84. PubMed Europe PubMed DOI
Pieters,K., Pettersson,A., Gullberg,U. and Hellmark,T. The - 564 A/G polymorphism in the promoter region of the proteinase 3 gene associated with Wegener's granulomatosis does not increase the promoter activity Clin Exp Immunol (2004) 138, 266-270. PubMed Europe PubMed DOI PMC EPMC M
Rao,N.V. and Hoidal,J.R. Myeloblastin [ISSN:0-12-079610-4] (2004) 2, 1526-1530. V

2003

Duranton,J. and Bieth,J.G. Inhibition of proteinase 3 by [alpha]1-antitrypsin in vitro predicts very fast inhibition in vivo Am J Respir Cell Mol Biol (2003) 29, 57-61. PubMed Europe PubMed DOI
Pezzato,E., Dona,M., Sartor,L., Dell'Aica,I., Benelli,R., Albini,A. and Garbisa,S. Proteinase-3 directly activates MMP-2 and degrades gelatin and Matrigel; differential inhibition by (-)epigallocatechin-3-gallate J Leukoc Biol (2003) 74, 88-94. PubMed Europe PubMed DOI
Schreiber,A., Busjahn,A., Luft,F.C. and Kettritz,R. Membrane expression of proteinase 3 is genetically determined J Am Soc Nephrol (2003) 14, 68-75. PubMed Europe PubMed DOI

2002

[YEAR:18-10-2002]Korkmaz,B., Attucci,S., Hazouard,E., Ferrandiere,M., Jourdan,M.L., Brillard-Bourdet,M., Juliano,L. and Gauthier,F. Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates J Biol Chem (18-10-2002) 277, 39074-39081. PubMed Europe PubMed DOI A
[YEAR:1-1-2002]Ramaha,A. and Patston,P.A. Release and degradation of angiotensin I and angiotensin II from angiotensinogen by neutrophil serine proteinases Arch Biochem Biophys (1-1-2002) 397, 77-83. PubMed Europe PubMed DOI
Rarok,A.A., Stegeman,C.A., Limburg,P.C. and Kallenberg,C.G. Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis J Am Soc Nephrol (2002) 13, 2232-2238. PubMed Europe PubMed DOI
[YEAR:1-6-2002]Van der Geld,Y.M., Smook,M.L., Huitema,M.G., Harmsen,M.C., Limburg,P.C. and Kallenberg,C.G. Expression of recombinant proteinase 3, the autoantigen in Wegener's granulomatosis, in insect cells J Immunol Methods (1-6-2002) 264, 195-205. PubMed Europe PubMed DOI E
Wu,Y.Y., Hsu,T.C., Chen,T.Y., Liu,T.C., Liu,G.Y., Lee,Y.J. and Tsay,G.J. Proteinase 3 and dihydrolipoamide dehydrogenase (E3) are major autoantigens in hepatitis C virus (HCV) infection Clin Exp Immunol (2002) 128, 347-352. PubMed Europe PubMed DOI PMC EPMC
Ying,Q.L. and Simon,S.R. Elastolysis by proteinase 3 and its inhibition by alpha(1)-proteinase inhibitor: a mechanism for the incomplete inhibition of ongoing elastolysis Am J Respir Cell Mol Biol (2002) 26, 356-361. PubMed Europe PubMed DOI

2001

[YEAR:15-6-2001]Sorensen,O.E., Follin,P., Johnsen,A.H., Calafat,J., Tjabringa,G.S., Hiemstra,P.S. and Borregaard,N. Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3 Blood (15-6-2001) 97, 3951-3959. PubMed Europe PubMed DOI
Taekema-Roelvink,M.E., Van Kooten,C., Van der Kooij,S., Heemskerk,E. and Daha,M.R. Proteinase 3 enhances endothelial monocyte chemoattractant protein-1 production and induces increased adhesion of neutrophils to endothelial cells by upregulating intercellular cell adhesion molecule-1 J Am Soc Nephrol (2001) 12, 932-940. PubMed Europe PubMed
Van der Geld,Y.M., Limburg,P.C. and Kallenberg,C.G. Proteinase 3, Wegener's autoantigen: from gene to antigen J Leukoc Biol (2001) 69, 177-190. PubMed Europe PubMed
Ying,Q.L. and Simon,S.R. Kinetics of the inhibition of proteinase 3 by elafin Am J Respir Cell Mol Biol (2001) 24, 83-89. PubMed Europe PubMed DOI

2000

[YEAR:15-9-2000]Campbell,E.J., Campbell,M.A. and Owen,C.A. Bioactive proteinase 3 on the cell surface of human neutrophils: Quantification, catalytic activity, and susceptibility to inhibition J Immunol (15-9-2000) 165, 3366-3374. PubMed Europe PubMed
Gencik,M., Meller,S., Borgmann,S. and Fricke,H. Proteinase 3 gene polymorphisms and Wegener's granulomatosis Kidney Int (2000) 58, 2473-2477. PubMed Europe PubMed DOI M
[YEAR:15-2-2000]Lutz,P.G., Moog-Lutz,C., Coumau-Gatbois,E., Kobari,L., Di Gioia,Y. and Cayre,Y.E. Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells Proc Natl Acad Sci U S A (15-2-2000) 97, 1601-1606. PubMed Europe PubMed DOI PMC EPMC

1999

Belaaouaj,A., Moog-Lutz,C., Just,J., Houzel-Charavel,A., Shapiro,S.D. and Cayre,Y. Genomic organization and chromosomal localization of mouse proteinase 3 (myeloblastin) Mamm Genome (1999) 10, 210-212. PubMed Europe PubMed DOI
[YEAR:1-2-1999]Skold,S., Rosberg,B., Gullberg,U. and Olofsson,T. A secreted proform of neutrophil proteinase 3 regulates the proliferation of granulopoietic progenitor cells Blood (1-2-1999) 93, 849-856. PubMed Europe PubMed
Witko-Sarsat,V., Lesavre,P., Lopez,S., Bessou,G., Hieblot,C., Prum,B., Noel,L.H., Guillevin,L., Ravaud,P., Sermet-Gaudelus,I., Timsit,J., Grunfeld,J.P. and Halbwachs-Mecarelli,L. A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis J Am Soc Nephrol (1999) 10, 1224-1233. PubMed Europe PubMed
[YEAR:1-12-1999]Wong,E.T., Jenne,D.E., Zimmer,M., Porter,S.D. and Gilks,C.B. Changes in chromatin organization at the neutrophil elastase locus associated with myeloid cell differentiation Blood (1-12-1999) 94, 3730-3736. PubMed Europe PubMed

1998

He,Y., Young,P.K. and Grinnell,F. Identification of proteinase 3 as the major caseinolytic activity in acute human wound fluid J Invest Dermatol (1998) 110, 67-71. PubMed Europe PubMed DOI
Sturrock,A., Franklin,K.F., Wu,S. and Hoidal,J.R. Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2) Cytogenet Cell Genet (1998) 83, 104-108. PubMed Europe PubMed

1997

Aveskogh,M., Lutzelschwab,C., Huang,M.R. and Hellman,L. Characterization of cDNA clones encoding mouse proteinase 3 (myeloblastine) and cathepsin G Immunogenetics (1997) 46, 181-191. PubMed Europe PubMed DOI
Harmsen,M.C., Heeringa,P., Van der Geld,Y.M., Huitema,M.G., Klimp,A., Tiran,A. and Kallenberg,C.G. Recombinant proteinase 3 (Wegener's antigen) expressed in Pichia pastoris is functionally active and is recognized by patient sera Clin Exp Immunol (1997) 110, 257-264. PubMed Europe PubMed PMC EPMC
[YEAR:15-11-1997]Heegaard,N.H., Jakobsen,D.R. and Klattschou,D. Purification of Wegener's granulomatosis autoantigen, proteinase 3, from neutrophils by Triton X-114 extraction of azurophilic granules Anal Biochem (15-11-1997) 253, 259-262. PubMed Europe PubMed DOI
Jenne,D.E., Frohlich,L., Hummel,A.M. and Specks,U. Cloning and functional expression of the murine homologue of proteinase 3: implications for the design of murine models of vasculitis FEBS Lett (1997) 408, 187-190. PubMed Europe PubMed DOI
Stummann,L. and Wiik,A. A simple high yield procedure for purification of human proteinase 3, the main molecular target of cANCA J Immunol Methods (1997) 206, 35-42. PubMed Europe PubMed DOI

1996

Baici,A., Szedlacsek,S.E., Fruh,H. and Michel,B.A. pH-dependent hysteretic behaviour of human myeloblastin (leucocyte proteinase 3) Biochem J (1996) 317, 901-905. PubMed Europe PubMed PMC EPMC
Fruh,H., Kostoulas,G., Michel,B.A. and Baici,A. Human myeloblastin (leukocyte proteinase 3): Reactions with substrates, inactivators and activators in comparison with leukocyte elastase Biol Chem (1996) 377, 579-586. PubMed Europe PubMed
Fujinaga,M., Chernaia,M.M., Halenbeck,R., Koths,K. and James,M.N. The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies J Mol Biol (1996) 261, 267-278. PubMed Europe PubMed DOI S
Groutas,W.C., Epp,J.B., Venkataraman,R., Kuang,R., Truong,T.M., McClenahan,J.J. and Prakash,O. Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners Bioorg Med Chem (1996) 4, 1393-1400. PubMed Europe PubMed DOI I
Specks,U., Fass,D.N., Fautsch,M.P., Hummel,A.M. and Viss,M.A. Recombinant human proteinase 3, the Wegener's autoantigen, expressed in HMC-1 cells is enzymatically active and recognized by c-ANCA FEBS Lett (1996) 390, 265-270. PubMed Europe PubMed DOI
[YEAR:13-12-1996]Sturrock,A., Franklin,K.F. and Hoidal,J.R. Human proteinase-3 expression is regulated by PU.1 in conjunction with a cytidine-rich element J Biol Chem (13-12-1996) 271, 32392-32402. PubMed Europe PubMed DOI

1995

Groutas,W.C., Brubaker,M.J., Chong,L.S., Venkataraman,R., Huang,H., Epp,J.B., Kuang,R. and Hoidal,J.R. Design, synthesis and biological evaluation of succinimide derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3 Bioorg Med Chem (1995) 3, 375-381. PubMed Europe PubMed DOI I
Robache-Gallea,S., Morand,V., Bruneau,J.M., Schoot,B., Tagat,E., Realo,E., Chouaib,S. and Roman-Roman,S. In vitro processing of human tumor necrosis factor-alpha J Biol Chem (1995) 270, 23688-23692. PubMed Europe PubMed DOI

1994

Hoidal,J.R., Rao,N.V. and Gray,B. Myeloblastin: leukocyte proteinase 3 Methods Enzymol (1994) 244, 61-67. PubMed Europe PubMed DOI V

1993

Dolman,K.M., van de Wiel,B.A., Kam,C.M., Kerrigan,J.E., Hack,C.E., von dem Borne,A.E., Powers,J.C. and Goldschmeding,R. Proteinase 3: Substrate specificity and possible pathogenetic effect of Wegener's granulomatosis autoantibodies (C-ANCA) by dysregulation of the enzyme Adv Exp Med Biol (1993) 336, 55-60. PubMed Europe PubMed
Rao,N.V., Marshall,B.C., Gray,B.H. and Hoidal,J.R. Interaction of secretory leukocyte protease inhibitor with proteinase-3 Am J Respir Cell Mol Biol (1993) 8, 612-616. PubMed Europe PubMed DOI

1992

[YEAR:16-11-1992]Brubaker,M.J., Groutas,W.C., Hoidal,J.R. and Rao,N.V. Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters Biochem Biophys Res Commun (16-11-1992) 188, 1318-1324. PubMed Europe PubMed DOI
Kam,C.M., Kerrigan,J.E., Dolman,K.M., Goldschmeding,R., von dem Borne,A.E. and Powers,J.C. Substrate and inhibitor studies on proteinase 3 FEBS Lett (1992) 297, 119-123. PubMed Europe PubMed DOI

1991

Abrahamson,M., Buttle,D.J., Mason,R.W., Hansson,H., Grubb,A., Lilja,H. and Ohlsson,K. Regulation of cystatin C activity by serine proteinases Biomed Biochim Acta (1991) 50, 587-593. PubMed Europe PubMed
Labbaye,C., Musette,P. and Cayre,Y.E. Wegener autoantigen and myeloblastin are encoded by a single mRNA Proc Natl Acad Sci U S A (1991) 88, 9253-9256. PubMed Europe PubMed PMC EPMC
Rao,N.V., Wehner,N.G., Marshall,B.C., Gray,W.R., Gray,B.H. and Hoidal,J.R. Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties J Biol Chem (1991) 266, 9540-9548. PubMed Europe PubMed
Wiedow,O., Luademann,J. and Utecht,B. Elafin is a potent inhibitor of proteinase 3 Biochem Biophys Res Commun (1991) 174, 6-10. PubMed Europe PubMed DOI

1990

Campanelli,D., Detmers,P.A., Nathan,C.F. and Gabay,J.E. Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties J Clin Invest (1990) 85, 904-915. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-12-1990]Campanelli,D., Melchior,M., Fu,Y., Nakata,M., Shuman,H., Nathan,C. and Gabay,J.E. Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils J Exp Med (1-12-1990) 172, 1709-1715. PubMed Europe PubMed DOI PMC EPMC
Ludemann,J., Utecht,B. and Gross,W.L. Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme J Exp Med (1990) 171, 357-362. PubMed Europe PubMed DOI PMC EPMC
Wilde,C.G., Snable,J.L., Griffith,J.E. and Scott,R.W. Characterization of two azurophil granule proteases with active-site homology to neutrophil elastase J Biol Chem (1990) 265, 2038-2041. PubMed Europe PubMed

1989

Bories,D., Raynal,M.C., Solomon,D.H., Darzynkiewicz,Z. and Cayre,Y.E. Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells Cell (1989) 59, 959-968. PubMed Europe PubMed DOI

1988

Kao,R.C., Wehner,N.G., Skubitz,K.M., Gray,B.H. and Hoidal,J.R. Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters J Clin Invest (1988) 82, 1963-1973. PubMed Europe PubMed DOI PMC EPMC