Structure for peptidase M28.002: aminopeptidase Ap1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1AMP	Vibrio proteolyticus	1.80 Å	mature
The catalytic zinc ions are shown as light grey CPK spheres. The zinc ligands are shown in ball-and-stick representation: His203 and His362 in purple; Asp223 and Asp285 in pink; and Glu258 in dark blue. The putative catalytic residues are also shown in ball-and-stick representation: Asp205 in pink and Glu257 in dark blue.

		Show surface

TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Vibrio proteolyticus
mature peptidase	1.80 Å	1AMP	1AMP	1AMP	1AMP	1AMP	1AMP	Chevrier et al., 1994
complex with 1-butaneboronic acid	1.90 Å	1CP6	1CP6	1CP6	1CP6	1CP6	1CP6	De et al., 1999
complex with L-Leu-phosphonic acid	2.20 Å	1FT7	1FT7	1FT7	1FT7	1FT7	1FT7	Stamper et al., 2001
complex with para-iodo-D-Phe hydroxamate	2.30 Å	1IGB	1IGB	1IGB	1IGB	1IGB	1IGB	Chevrier et al., 1996
complex with Tris buffer	1.20 Å	1LOK	1LOK	1LOK	1LOK	1LOK	1LOK	Desmarais et al., 2002
mature peptidase	0.95 Å	1RTQ	1RTQ	1RTQ	1RTQ	1RTQ	1RTQ	Desmarais et al., 2006
complex with bestatin	2.00 Å	1TXR	1TXR	1TXR	1TXR	1TXR	1TXR	Stamper et al., 2004
complex with bestatin	2.10 Å	1XRY	1XRY	1XRY	1XRY	1XRY	1XRY
functional glutamate 151 to histidine mutant of the aminopeptidase from aeromonas proteolytica.	1.90 Å	2ANP	2ANP	2ANP	2ANP	2ANP	2ANP	Bzymek et al., 2005
structure at pH 4.7.	1.24 Å	2DEA	2DEA	2DEA	2DEA	2DEA	2DEA	Desmarais et al., 2006
complex with leucyl-leucyl-leucine.	2.00 Å	2IQ6	2IQ6	2IQ6	2IQ6	2IQ6	2IQ6	Kumar et al., 2007
structure of vibrio proteolyticus aminopeptidase with a bound trp fragment of dlwcf	2.50 Å	2NYQ	2NYQ	2NYQ	2NYQ	2NYQ	2NYQ
Co(II) substituted Tris-bound form	2.15 Å	2PRQ	2PRQ	2PRQ	2PRQ	2PRQ	2PRQ	Munih et al., 2007
Met180Ala mutant	1.10 Å	3B35	3B35	3B35	3B35	3B35	3B35	Ataie et al., 2008
Met180Ala mutant; complex with leucine phosphonic acid	1.46 Å	3B3C	3B3C	3B3C	3B3C	3B3C	3B3C	Ataie et al., 2008
Met180Ala mutant; complex with leucine	1.18 Å	3B3S	3B3S	3B3S	3B3S	3B3S	3B3S	Ataie et al., 2008
Asp118Asn mutant	1.17 Å	3B3T	3B3T	3B3T	3B3T	3B3T	3B3T	Ataie et al., 2008
Ser228Ala mutant	1.22 Å	3B3V	3B3V	3B3V	3B3V	3B3V	3B3V	Ataie et al., 2008
Ser228Ala mutant; complex with leucine	1.75 Å	3B3W	3B3W	3B3W	3B3W	3B3W	3B3W	Ataie et al., 2008
Ser228Ala mutant; complex with leucine phosphonic acid	1.75 Å	3B7I	3B7I	3B7I	3B7I	3B7I	3B7I	Ataie et al., 2008
mature peptidase	1.95 Å	3FH4	3FH4	3FH4	3FH4	3FH4	3FH4	Hartley et al., 2009
mature peptidase	1.29 Å	3VH9	3VH9	3VH9	3VH9	3VH9	3VH9	Hanaya et al., 2012