Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P00698

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
18	unknown peptidase	1-147	P	release of a signal peptide	NT	Canfield 1963
19	aminopeptidase Ap1	19-147	N			Wilkes et al., 1973
20	aminopeptidase Ap1	19-147	N			Wilkes et al., 1973
21	aminopeptidase Ap1	19-147	N			Wilkes et al., 1973
22	aminopeptidase Ap1	19-147	N			Wilkes et al., 1973
23	aminopeptidase Ap1	19-147	N			Wilkes et al., 1973
23	trypsin 1	19-147	N			Semenova et al., 2008
23	kallikrein 1-related peptidase c2 (Rattus norvegicus)	19-147	N			Moreau et al., 1992
32	trypsin 1	19-147	N			Semenova et al., 2008
32	kallikrein 1-related peptidase c9 (Rattus sp.)	19-147	N			Moreau et al., 1992
35	pepsin A	19-147	P	normal turnover	MS	Ibrahim et al., 2005
35	peptidyl-Asp metallopeptidase	18-147	N		MS	Kameoka et al., 2003
39	trypsin 1	19-147	N			Semenova et al., 2008
39	kallikrein 1-related peptidase c9 (Rattus sp.)	19-147	N			Moreau et al., 1992
41	kallikrein 1-related peptidase c2 (Rattus norvegicus)	19-147	N			Moreau et al., 1992
56	pepsin A	19-147	P	normal turnover	MS	Ibrahim et al., 2005
56	brachyurin-C	19-147	N			Semenova et al., 2008
56	trypsin 1	19-147	N			Semenova et al., 2008
62	legumain, animal-type	19-147	P		NT	Dando et al., 1999
63	brachyurin-C	19-147	N			Semenova et al., 2008
63	trypsin 1	19-147	N			Semenova et al., 2008
63	kallikrein 1-related peptidase c9 (Rattus sp.)	19-147	N			Moreau et al., 1992
64	legumain, animal-type	19-147	P		NT	Dando et al., 1999
65	peptidyl-Asp metallopeptidase	18-147	N		MS	Kameoka et al., 2003
69	peptidyl-Asp metallopeptidase	18-147	N		MS	Kameoka et al., 2003
71	SplA peptidase (Staphylococcus aureus)	19-147	N			Stec-Niemczyk et al., 2009
74	pepsin A	19-147	P	normal turnover	MS	Ibrahim et al., 2005
79	trypsin 1	19-147	N			Semenova et al., 2008
79	kallikrein 1-related peptidase c2 (Rattus norvegicus)	19-147	N			Moreau et al., 1992
79	kallikrein 1-related peptidase c9 (Rattus sp.)	19-147	N			Moreau et al., 1992
83	peptidyl-Asp metallopeptidase	18-147	N		MS	Kameoka et al., 2003
86	brachyurin-C	19-147	N			Semenova et al., 2008
91	trypsin 1	19-147	N			Semenova et al., 2008
101	brachyurin-C	19-147	N			Semenova et al., 2008
104	peptidyl-Asp metallopeptidase	18-147	N		MS	Kameoka et al., 2003
114	trypsin 1	19-147	N			Semenova et al., 2008
114	kallikrein 1-related peptidase c9 (Rattus sp.)	19-147	N			Moreau et al., 1992
118	peptidyl-Asp metallopeptidase	18-147	N		MS	Kameoka et al., 2003
126	brachyurin-C	19-147	N			Semenova et al., 2008
126	trypsin 1	19-147	N			Semenova et al., 2008
130	trypsin 1	19-147	N			Semenova et al., 2008
132	brachyurin-C	19-147	N			Semenova et al., 2008
132	trypsin 1	19-147	N			Semenova et al., 2008
132	kallikrein 1-related peptidase c9 (Rattus sp.)	19-147	N			Moreau et al., 1992
134	trypsin 1	19-147	N			Semenova et al., 2008
136	peptidyl-Asp metallopeptidase	18-147	N		MS	Kameoka et al., 2003
143	trypsin 1	19-147	N			Semenova et al., 2008
143	kallikrein 1-related peptidase c9 (Rattus sp.)	19-147	N			Moreau et al., 1992