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Display Known Cleavages for a Protein

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Accession:

Sequence P61823

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
26	unknown peptidase	1-150	P	release of a signal peptide	NT	Plummer & Hirs, 1964
27	aminopeptidase Ap1	27-150	N			Wilkes et al., 1973
30	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
31	pepsin A	27-150	N		NT	Huang & Tang, 1969
31	gastricsin	27-150	N		NT	Huang & Tang, 1969
34	pepsin A	27-150	N		NT	Huang & Tang, 1969
34	gastricsin	27-150	N		NT	Huang & Tang, 1969
34	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
35	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
38	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
40	syncephapepsin	27-150	N			Ho et al., 1998
40	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
42	subtilisin Carlsberg	27-150	N			Mendez et al., 2000
44	subtilisin Carlsberg	27-150	N			Mendez et al., 2000
45	subtilisin Carlsberg	27-150	N			Mendez et al., 2000
46	subtilisin Carlsberg	27-150	N			Richards & Vithayathil, 1959
47	subtilisin Carlsberg	27-150	N			Mendez et al., 2000
51	chymotrypsin A (cattle-type)	27-150	N			Polverino de Laureto et al., 1997
57	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
57	trypsin 1	27-150	N			Polverino de Laureto et al., 1997
58	pepsin A	27-150	N		NT	Huang & Tang, 1969
58	gastricsin	27-150	N		NT	Huang & Tang, 1969
59	trypsin 1	27-150	N			Polverino de Laureto et al., 1997
60	pepsin A	27-150	N		NT	Huang & Tang, 1969
60	gastricsin	27-150	N		NT	Huang & Tang, 1969
60	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
60	thermolysin	27-150	N			Polverino de Laureto et al., 1997
61	chymotrypsin A (cattle-type)	27-150	N			Polverino de Laureto et al., 1997
63	trypsin 1	27-150	N			Polverino de Laureto et al., 1997
69	pepsin A	27-150	N		NT	Huang & Tang, 1969
69	gastricsin	27-150	N		NT	Huang & Tang, 1969
70	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
71	pepsin A	27-150	N		NT	Huang & Tang, 1969
71	gastricsin	27-150	N		NT	Huang & Tang, 1969
71	thermolysin	27-150	N			Polverino de Laureto et al., 1997
72	pepsin A	27-150	N		NT	Huang & Tang, 1969
72	gastricsin	27-150	N		NT	Huang & Tang, 1969
72	syncephapepsin	27-150	N			Ho et al., 1998
72	chymotrypsin A (cattle-type)	27-150	N			Polverino de Laureto et al., 1997
74	pepsin A	27-150	N		NT	Huang & Tang, 1969
74	gastricsin	27-150	N		NT	Huang & Tang, 1969
74	aspergilloglutamic peptidase	27-150	N		AA	Takahashi, 1997
75	pepsin A	27-150	N		NT	Huang & Tang, 1969
75	gastricsin	27-150	N		NT	Huang & Tang, 1969
75	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
77	pepsin A	27-150	N		NT	Huang & Tang, 1969
77	gastricsin	27-150	N		NT	Huang & Tang, 1969
78	pepsin A	27-150	N		NT	Huang & Tang, 1969
78	gastricsin	27-150	N		NT	Huang & Tang, 1969
79	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
81	pepsin A	27-150	N		NT	Huang & Tang, 1969
81	gastricsin	27-150	N		NT	Huang & Tang, 1969
81	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
86	aspergilloglutamic peptidase	27-150	N		AA	Takahashi, 1997
88	aspergilloglutamic peptidase	27-150	N		AA	Takahashi, 1997
93	aspergilloglutamic peptidase	27-150	N		AA	Takahashi, 1997
99	gastricsin	27-150	N		NT	Huang & Tang, 1969
99	syncephapepsin	27-150	N			Ho et al., 1998
100	pepsin A	27-150	N		NT	Huang & Tang, 1969
100	gastricsin	27-150	N		NT	Huang & Tang, 1969
100	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
102	gastricsin	27-150	N		NT	Huang & Tang, 1969
102	aspergilloglutamic peptidase	27-150	N		AA	Takahashi, 1997
102	subtilisin Carlsberg	27-150	N			Polverino de Laureto et al., 1997
104	syncephapepsin	27-150	N			Ho et al., 1998
105	pepsin A	27-150	N		NT	Huang & Tang, 1969
105	gastricsin	27-150	N		NT	Huang & Tang, 1969
105	aspergilloglutamic peptidase	27-150	N		NT	Takahashi, 1997
105	subtilisin Carlsberg	27-150	N			Polverino de Laureto et al., 1997
109	aspergilloglutamic peptidase	27-150	N		NT	Takahashi, 1997
111	pepsin A	27-150	N		NT	Huang & Tang, 1969
111	gastricsin	27-150	N		NT	Huang & Tang, 1969
112	aspergilloglutamic peptidase	27-150	N		NT	Takahashi, 1997
115	pepsin A	27-150	N		NT	Huang & Tang, 1969
115	gastricsin	27-150	N		NT	Huang & Tang, 1969
117	syncephapepsin	27-150	N			Ho et al., 1998
117	aspergilloglutamic peptidase	27-150	N		AA	Takahashi, 1997
118	pepsin A	27-150	N		NT	Huang & Tang, 1969
118	gastricsin	27-150	N		NT	Huang & Tang, 1969
122	syncephapepsin	27-150	N			Ho et al., 1998
123	aspergilloglutamic peptidase	27-150	N		AA	Takahashi, 1997
124	aspergilloglutamic peptidase	27-150	N		AA	Takahashi, 1997
127	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
129	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
131	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
134	pepsin A	27-150	N		NT	Huang & Tang, 1969
135	HIV-1 retropepsin	27-150	N			Tomasselli et al., 1991
137	aspergilloglutamic peptidase	27-150	N		AA	Takahashi, 1997
141	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
144	pepsin A	27-150	N		NT	Huang & Tang, 1969
144	gastricsin	27-150	N		NT	Huang & Tang, 1969
145	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
146	pepsin A	27-150	N		NT	Huang & Tang, 1969
146	gastricsin	27-150	N		NT	Huang & Tang, 1969
146	aspergilloglutamic peptidase	27-150	N			Takahashi, 1997
147	aspergilloglutamic peptidase	27-150	N		NT	Takahashi, 1997