Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P01274

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
20	unknown peptidase	1-180	P	release of a signal peptide	NT	Thim & Moody, 1981
52	unknown peptidase	1-180	P		NT	<%Agarwal et al., 2012[]%>
53	aminopeptidase Ap1	53-81	N			Wilkes et al., 1973
54	dipeptidyl-peptidase I	53-81	P		NT	McDonald et al., 1969
54	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
54	aminopeptidase Ap1	54-81	N			Wilkes et al., 1973
54	unknown peptidase	53-81	P			Bertenshaw et al., 2001
55	aminopeptidase Ap1	55-81	N			Wilkes et al., 1973
55	chymotrypsin C	53-81	N		NT	Folk et al., 1965
56	dipeptidyl-peptidase I	53-81	P		NT	McDonald et al., 1969
56	meprin beta subunit	53-81	N			Bertenshaw et al., 2001
56	aminopeptidase Ap1	56-81	N			Wilkes et al., 1973
57	halylysin c	53-81	N			Komori & Nikai, 2004
57	aminopeptidase Ap1	57-81	N			Wilkes et al., 1973
57	neutral endopeptidase (Micrococcus caseolyticus)	53-81	N			Desmazeaud & Hermier, 1971
58	pepsin A	53-81	N		NT	Huang & Tang, 1969
58	gastricsin	53-81	N		NT	Huang & Tang, 1969
58	crustapain	53-81	N			Aoki et al., 2003
58	dipeptidyl-peptidase I	53-81	P		NT	McDonald et al., 1969
58	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
58	pitrilysin	53-81	N			Cornista et al., 2004
58	aminopeptidase Ap1	58-81	N			Wilkes et al., 1973
58	chymotrypsin A (cattle-type)	53-81	N			Folk et al., 1965
58	chymotrypsin C	53-81	N		NT	Folk et al., 1965
58	metridin	53-81	N			Barrett, 2004
58	unknown peptidase	53-81	P			Bertenshaw et al., 2001
59	cathepsin L	53-81	N			Aoki et al., 2003
59	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
59	halylysin c	53-81	N			Komori & Nikai, 2004
59	aminopeptidase Ap1	59-81	N			Wilkes et al., 1973
59	unknown peptidase	53-81	P			Bertenshaw et al., 2001
60	crustapain	53-81	N			Aoki et al., 2003
60	dipeptidyl-peptidase I	53-81	P		NT	McDonald et al., 1969
60	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
60	meprin beta subunit	53-81	N			Bertenshaw et al., 2001
60	hyicolysin	53-81	N			Gotz, 2004
60	peptidyl-Asp metallopeptidase	53-81	N			Hagmann, 2004
60	unknown peptidase	53-81	P			Bertenshaw et al., 2001
61	pepsin A	53-81	N		NT	Huang & Tang, 1969
61	gastricsin	53-81	N		NT	Huang & Tang, 1969
61	phytepsin	53-81	N			Kervinen et al., 2004
61	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
61	glutamyl peptidase BI	53-81	N			Leshchinskaya et al., 1997
61	unknown peptidase	53-81	P			Bertenshaw et al., 2001
62	gastricsin	53-81	N		NT	Huang & Tang, 1969
62	dipeptidyl-peptidase I	53-81	P		NT	McDonald et al., 1969
62	leishmanolysin	53-81	N			Bouvier, 2004
62	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
62	lebetase	53-81	N			Siigur & Siigur, 2004
62	chymotrypsin A (cattle-type)	53-81	N			Folk et al., 1965
62	chymotrypsin C	53-81	N		NT	Folk et al., 1965
62	unknown peptidase	53-81	N		MS	Siigur et al., 2011
62	metridin	53-81	N			Barrett, 2004
62	unknown peptidase	53-81	P			Bertenshaw et al., 2001
63	cathepsin L	53-81	N			Aoki et al., 2003
63	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
63	unknown peptidase	53-81	P			Bertenshaw et al., 2001
64	saccharopepsin	53-81	N			Bowman, 2004
64	dipeptidyl-peptidase I	53-81	P		NT	McDonald et al., 1969
64	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
64	pitrilysin	53-81	N			Cornista et al., 2004
64	hyicolysin	53-81	N			Gotz, 2004
64	unknown peptidase	53-81	P			Bertenshaw et al., 2001
65	gastricsin	53-81	N		NT	Huang & Tang, 1969
65	phytepsin	53-81	N			Kervinen et al., 2004
65	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
65	halylysin c	53-81	N			Komori & Nikai, 2004
65	neutral endopeptidase (Micrococcus caseolyticus)	53-81	N			Desmazeaud & Hermier, 1971
65	chymotrypsin A (cattle-type)	53-81	N			Folk et al., 1965
65	chymotrypsin C	53-81	N		NT	Folk et al., 1965
65	unknown peptidase	53-81	N		MS	Siigur et al., 2011
65	metridin	53-81	N			Barrett, 2004
65	unknown peptidase	53-81	P			Bertenshaw et al., 2001
66	phytepsin	53-81	N			Kervinen et al., 2004
66	dipeptidyl-peptidase I	53-81	P		NT	McDonald et al., 1969
66	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
66	meprin beta subunit	53-81	N			Bertenshaw et al., 2001
66	peptidyl-Asp metallopeptidase	53-81	N			Hagmann, 2004
66	chymotrypsin C	53-81	N		NT	Folk et al., 1965
66	unknown peptidase	53-81	N		MS	Siigur et al., 2011
66	unknown peptidase	53-81	P			Bertenshaw et al., 2001
67	cathepsin L	53-81	N			Aoki et al., 2003
67	leishmanolysin	53-81	N			Bouvier, 2004
67	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
67	halylysin c	53-81	N			Komori & Nikai, 2004
67	hyicolysin	53-81	N			Gotz, 2004
67	glutamyl peptidase BI	53-81	N			Leshchinskaya et al., 1997
67	unknown peptidase	53-81	P			Bertenshaw et al., 2001
68	phytepsin	53-81	N			Kervinen et al., 2004
68	dipeptidyl-peptidase I	53-81	P		NT	McDonald et al., 1969
68	neutral endopeptidase (Micrococcus caseolyticus)	53-81	N			Desmazeaud & Hermier, 1971
69	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
69	unknown peptidase	53-81	P			Bertenshaw et al., 2001
70	phytepsin	53-81	N			Kervinen et al., 2004
70	meprin beta subunit	53-81	N			Bertenshaw et al., 2001
70	hyicolysin	53-81	N			Gotz, 2004
70	neutral endopeptidase (Micrococcus caseolyticus)	53-81	N			Desmazeaud & Hermier, 1971
70	miniglucagon endopeptidase	53-81	P		NT	Fontes et al., 2005
72	crustapain	53-81	N			Aoki et al., 2003
72	meprin beta subunit	53-81	N			Bertenshaw et al., 2001
72	peptidyl-Asp metallopeptidase	53-81	N			Hagmann, 2004
72	chymotrypsin C	53-81	N		NT	Folk et al., 1965
72	unknown peptidase	53-81	P			Bertenshaw et al., 2001
73	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
73	halylysin c	53-81	N			Komori & Nikai, 2004
73	neutral endopeptidase (Micrococcus caseolyticus)	53-81	N			Desmazeaud & Hermier, 1971
73	glutamyl peptidase BI	53-81	N			Leshchinskaya et al., 1997
73	unknown peptidase	53-81	P			Bertenshaw et al., 2001
74	pepsin A	53-81	N		NT	Huang & Tang, 1969
74	gastricsin	53-81	N		NT	Huang & Tang, 1969
74	phytepsin	53-81	N			Kervinen et al., 2004
74	chymotrypsin A (cattle-type)	53-81	N			Folk et al., 1965
74	chymotrypsin C	53-81	N		NT	Folk et al., 1965
74	metridin	53-81	N			Barrett, 2004
75	cathepsin L	53-81	N			Aoki et al., 2003
76	saccharopepsin	53-81	N
76	crustapain	53-81	N			Aoki et al., 2003
76	cathepsin L	53-81	N			Aoki et al., 2003
76	hyicolysin	53-81	N			Gotz, 2004
76	chymotrypsin C	53-81	N		NT	Folk et al., 1965
76	thermomycolin	53-81	N			Gaucher & Stevenson, 2004
77	saccharopepsin	53-81	N			Bowman, 2004
77	phytepsin	53-81	N			Kervinen et al., 2004
77	crustapain	53-81	N			Aoki et al., 2003
77	leishmanolysin	53-81	N			Bouvier, 2004
77	meprin alpha subunit	53-81	N		NT	Bertenshaw et al., 2001
77	neutral endopeptidase (Micrococcus caseolyticus)	53-81	N			Desmazeaud & Hermier, 1971
77	chymotrypsin A (cattle-type)	53-81	N			Folk et al., 1965
77	chymotrypsin C	53-81	N		NT	Folk et al., 1965
77	unknown peptidase	53-81	P			Bertenshaw et al., 2001
78	pepsin A	53-81	N		NT	Huang & Tang, 1969
78	gastricsin	53-81	N		NT	Huang & Tang, 1969
78	saccharopepsin	53-81	N
78	phytepsin	53-81	N			Kervinen et al., 2004
78	chymotrypsin A (cattle-type)	53-81	N			Barrett, 2004
78	chymotrypsin C	53-81	N		NT	Folk et al., 1965
78	metridin	53-81	N			Barrett, 2004
79	cathepsin L	53-81	N			Aoki et al., 2003
79	chymotrypsin C	53-81	N		NT	Folk et al., 1965
80	crustapain	53-81	N			Aoki et al., 2003
83	unknown peptidase	1-180	P		NT	<%Agarwal et al., 2012[]%>
89	unknown peptidase	1-180	P		NT	<%Agarwal et al., 2012[]%>
91	unknown peptidase	1-180	P		NT	<%Agarwal et al., 2012[]%>
93	dipeptidyl-peptidase IV (eukaryote)	92-128	P			Kieffer et al., 1995
97	unknown peptidase	1-180	P		NT	<%Agarwal et al., 2012[]%>
130	unknown peptidase	1-180	P		NT	<%Agarwal et al., 2012[]%>
145	unknown peptidase	1-180	P		NT	<%Agarwal et al., 2012[]%>