$VAR1 = undef;

Summary for peptidase M16.009: eupitrilysin

Names
MEROPS Name	eupitrilysin
Other names	Mername-AA013 peptidase, hPreP, metalloprotease 1, peptidasome, pitrilysin-like metalloprotease, PITRM1 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan ME >> Subclan (none) >> Family M16 >> Subfamily C >> M16.009
Holotype	eupitrilysin (Homo sapiens), Uniprot accession Q5JRX3 (peptidase unit: 96-243), MERNUM MER0004877
History	Identifier created: MEROPS 3.1 (22 December 1998)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (31 cleavages)
Activity status	human: active (Mzhavia et al., 1999) mouse: putative
Other databases	TREEFAM	http://www.treefam.org/family/TF300333
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/v/-/--/-/-/- (based on 60 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	1	5	8	6	7	4	3
Pro	2	2	1	3	1	0	4	0
Ala	2	0	0	2	5	1	2	3
Val	6	16	9	1	6	11	6	2
Leu	4	4	4	4	5	6	2	8
Ile	1	5	1	0	5	4	1	2
Met	1	1	1	0	3	3	0	1
Phe	3	2	7	8	9	1	8	5
Tyr	3	1	1	9	0	1	1	1
Trp	0	0	0	0	0	0	0	2
Ser	2	1	0	2	4	6	2	1
Thr	1	0	6	6	2	1	7	4
Cys	1	1	0	1	0	0	0	0
Asn	1	1	3	0	0	1	1	2
Gln	1	7	5	1	1	6	6	1
Asp	2	0	0	2	0	2	3	2
Glu	0	1	2	0	0	2	2	3
Lys	8	2	2	6	6	1	5	3
Arg	10	6	4	7	7	4	0	3
His	1	2	2	0	0	3	0	0

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
PITRM1	10p15.2		ENSG00000107959	10531