Literature for peptidase M16.009: eupitrilysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, M Mutation, P Specificity, K Knockout, E Expression, V Review, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2023

Di Donfrancesco,A., Berlingieri,C., Giacomello,M., Frascarelli,C., Magalhaes Rebelo,A.P., Bindoff,L.A., Reeval,S., Renbaum,P., Santorelli,F.M., Massaro,G., Viscomi,C., Zeviani,M., Ghezzi,D., Bottani,E. and Brunetti,D. PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients Front Pharmacol (2023) 14, 1220620-1220620. PubMed Europe PubMed DOI PMC EPMC
Dou,Y. and Tan,Y. Presequence protease reverses mitochondria-specific amyloid-beta-induced mitophagy to protect mitochondria FASEB J (2023) 37, e22890-e22890. PubMed Europe PubMed DOI

2022

Liang,W.G., Wijaya,J., Wei,H., Noble,A.J., Mancl,J.M., Mo,S., Lee,D., Lin King,J.V., Pan,M., Liu,C., Koehler,C.M., Zhao,M., Potter,C.S., Carragher,B., Li,S. and Tang,W.J. Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition Nat Commun (2022) 13, 1833-1833. PubMed Europe PubMed DOI PMC EPMC

2020

Brunetti,D., Bottani,E., Segala,A., Marchet,S., Rossi,F., Orlando,F., Malavolta,M., Carruba,M.O., Lamperti,C., Provinciali,M., Nisoli,E. and Valerio,A. Targeting Multiple Mitochondrial Processes by a Metabolic Modulator Prevents Sarcopenia and Cognitive Decline in SAMP8 Mice Front Pharmacol (2020) 11, 1171-1171. PubMed Europe PubMed DOI PMC EPMC
Perez,M.J., Ivanyuk,D., Panagiotakopoulou,V., Di Napoli,G., Kalb,S., Brunetti,D., Al-Shaana,R., Kaeser,S.A., Fraschka,S.A., Jucker,M., Zeviani,M., Viscomi,C. and Deleidi,M. Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids Mol Psychiatry (2020) PubMed Europe PubMed DOI

2019

Jiang,K., Yang,Z., Cui,W., Su,K., Ma,J.Z., Payne,T.J. and Li,M.D. An exome-wide association study identifies new susceptibility loci for age of smoking initiation in African- and European-American populations Nicotine Tob Res (2019) 21, 707-713. PubMed Europe PubMed DOI M

2018

Langer,Y., Aran,A., Gulsuner,S., Abu Libdeh,B., Renbaum,P., Brunetti,D., Teixeira,P.F., Walsh,T., Zeligson,S., Ruotolo,R., Beeri,R., Dweikat,I., Shahrour,M., Weinberg-Shukron,A., Zahdeh,F., Baruffini,E., Glaser,E., King,M.C., Levy-Lahad,E., Zeviani,M. and Segel,R. Mitochondrial PITRM1 peptidase loss-of-function in childhood cerebellar atrophy J Med Genet (2018) 55, 599-606. PubMed Europe PubMed DOI M
Smith-Carpenter,J.E. and Alper,B.J. Functional requirement for human pitrilysin metallopeptidase 1 arginine 183, mutated in amyloidogenic neuropathy Protein Sci (2018) 27, 861-873. PubMed Europe PubMed DOI E M

2016

Brunetti,D., Torsvik,J., Dallabona,C., Teixeira,P., Sztromwasser,P., Fernandez-Vizarra,E., Cerutti,R., Reyes,A., Preziuso,C., D'Amati,G., Baruffini,E., Goffrini,P., Viscomi,C., Ferrero,I., Boman,H., Telstad,W., Johansson,S., Glaser,E., Knappskog,P.M., Zeviani,M. and Bindoff,L.A. Defective PITRM1 mitochondrial peptidase is associated with Abeta amyloidotic neurodegeneration EMBO Mol Med (2016) 8, 176-190. PubMed Europe PubMed DOI M

2015

Fang,D., Wang,Y., Zhang,Z., Du,H., Yan,S., Sun,Q., Zhong,C., Wu,L., Vangavaragu,J.R., Yan,S., Hu,G., Guo,L., Rabinowitz,M., Glaser,E., Arancio,O., Sosunov,A.A., McKhann,G.M., Chen,J.X. and Yan,S.S. Increased neuronal PreP activity reduces Abeta accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model Hum Mol Genet (2015) 24, 5198-5210. PubMed Europe PubMed DOI U
Guan,H., Chow,K.M., Song,E., Verma,N., Despa,F. and Hersh,L.B. The mitochondrial peptidase pitrilysin degrades islet amyloid polypeptide in beta-cells PLoS ONE (2015) 10, e0133263-e0133263. PubMed Europe PubMed DOI PMC EPMC

2014

Chen,J., Teixeira,P.F., Glaser,E. and Levine,R.L. Mechanism of oxidative inactivation of human presequence protease by hydrogen peroxide Free Radic Biol Med (2014) 77, 57-63. PubMed Europe PubMed DOI
King,J.V., Liang,W.G., Scherpelz,K.P., Schilling,A.B., Meredith,S.C. and Tang,W.J. Molecular basis of substrate recognition and degradation by human presequence protease Structure (2014) 22, 996-1007. PubMed Europe PubMed DOI S
Kmiec,B., Teixeira,P.F. and Glaser,E. Shredding the signal: targeting peptide degradation in mitochondria and chloroplasts Trends Plant Sci (2014) 19, 771-778. PubMed Europe PubMed DOI
Vangavaragu,J.R., Valasani,K.R., Gan,X. and Yan,S.S. Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer's disease Eur J Med Chem (2014) 76, 506-516. PubMed Europe PubMed DOI

2013

Teixeira,P.F. and Glaser,E. Processing peptidases in mitochondria and chloroplasts Biochim Biophys Acta (2013) 1833, 360-370. PubMed Europe PubMed DOI V

2012

Filipe Teixeira,P., Moreira Pinho,C., Branca,R.M., Lehtio,J., Levine,R.L. and Glaser,E. In vitro oxidative inactivation of human presequence protease (hPreP) Free Radic Biol Med (2012) 53, 2188-2195. PubMed Europe PubMed DOI
Kmiec,B. and Glaser,E. A novel mitochondrial and chloroplast peptidasome, PreP Physiol Plant (2012) 145, 180-186. PubMed Europe PubMed DOI K
Mzhavia,N. and Devi,L.A. Eupitrilysin [ISSN:978-0-12-407744-7] (2012) 3, 1457-1459. DOI

2011

Alikhani,N., Berglund,A.K., Engmann,T., Spanning,E., Vogtle,F.N., Pavlov,P., Meisinger,C., Langer,T. and Glaser,E. Targeting capacity and conservation of PreP homologues localization in mitochondria of different species J Mol Biol (2011) 410, 400-410. PubMed Europe PubMed DOI
Alikhani,N., Guo,L., Yan,S., Du,H., Pinho,C.M., Chen,J.X., Glaser,E. and Yan,S.S. Decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria J Alzheimers Dis (2011) 27, 75-87. PubMed Europe PubMed DOI

2010

Glaser,E. and Alikhani,N. The organellar peptidasome, PreP: a journey from Arabidopsis to Alzheimer's disease Biochim Biophys Acta (2010) 1797, 1076-1080. PubMed Europe PubMed DOI S
Pinho,C.M., Bjork,B.F., Alikhani,N., Backman,H.G., Eneqvist,T., Fratiglioni,L., Glaser,E. and Graff,C. Genetic and biochemical studies of SNPs of the mitochondrial A beta-degrading protease, hPreP Neurosci Lett (2010) 469, 204-208. PubMed Europe PubMed DOI

2009

Alikhani,N., Ankarcrona,M. and Glaser,E. Mitochondria and Alzheimer's disease: amyloid-beta peptide uptake and degradation by the presequence protease, hPreP J Bioenerg Biomembr (2009) 41, 447-451. PubMed Europe PubMed DOI
Chow,K.M., Gakh,O., Payne,I.C., Juliano,M.A., Juliano,L., Isaya,G. and Hersh,L.B. Mammalian pitrilysin: substrate specificity and mitochondrial targeting Biochemistry (2009) 48, 2868-2877. PubMed Europe PubMed DOI PMC EPMC P

2006

[YEAR:18-7-2006]Falkevall,A., Alikhani,N., Bhushan,S., Pavlov,P.F., Busch,K., Johnson,K.A., Eneqvist,T., Tjernberg,L., Ankarcrona,M. and Glaser,E. Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP J Biol Chem (18-7-2006) 281, 29096-29104. PubMed Europe PubMed DOI

2004

Mzhavia,N. and Devi,L.A. Metalloprotease 1 [ISSN:0-12-079610-4] (2004) 2, 890-892. V

2003

[YEAR:1-1-2003]Suemizu,H., Aiba,K., Yoshikawa,T., Sharov,A.A., Shimozawa,N., Tamaoki,N. and Ko,M.S. Expression profiling of placentomegaly associated with nuclear transplantation of mouse ES cells Dev Biol (1-1-2003) 253, 36-53. PubMed Europe PubMed DOI

1999

Mzhavia,N., Berman,Y.L., Qian,Y., Yan,L. and Devi,L.A. Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases DNA Cell Biol (1999) 18, 369-380. PubMed Europe PubMed DOI