$VAR1 = undef;

Summary for peptidase M14.018: carboxypeptidase A6

Names
MEROPS Name	carboxypeptidase A6
Other names	CPA6 g.p. (Homo sapiens), CPAH, Mername-AA127 peptidase (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan MC >> Subclan (none) >> Family M14 >> Subfamily A >> M14.018
Holotype	carboxypeptidase A6 (Homo sapiens), Uniprot accession Q8N4T0 (peptidase unit: 128-437), MERNUM MER0013456
History	Identifier created: MEROPS 5.3 (4 December 2000)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: putative mouse: putative
Knockout	Disruption of the gene was associated with incidence of the human Duane retraction syndrome (Pizzuti et al., 2002).
Other databases	TREEFAM	http://www.treefam.org/family/TF317197
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/fl/-/-/- (based on 42 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'
Gly	2	5	5	0	0
Pro	2	5	2	1	0
Ala	3	0	3	4	4
Val	1	1	0	1	4
Leu	1	4	5	4	16
Ile	2	2	0	1	1
Met	0	2	1	0	4
Phe	2	2	2	15	3
Tyr	5	0	3	2	3
Trp	1	1	0	0	1
Ser	1	0	0	1	0
Thr	2	1	1	2	0
Cys	0	0	0	0	0
Asn	2	2	0	2	0
Gln	1	1	1	0	2
Asp	0	1	3	0	0
Glu	2	0	1	0	0
Lys	1	2	0	0	0
Arg	2	0	4	6	0
His	2	3	1	3	4