Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P05063

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-363	P		NT	<%Agarwal et al., 2012[]%>
31	cathepsin E	2-363	P		MS	Impens et al., 2010
106	cathepsin E	2-363	P		MS	Impens et al., 2010
162	cathepsin E	2-363	P		MS	Impens et al., 2010
174	cathepsin D	2-363	P		MS	Impens et al., 2010
176	cathepsin E	2-363	P		MS	Impens et al., 2010
179	matrix metallopeptidase-2	2-363	N		MS	Kleifeld et al., 2010
248	cathepsin E	2-363	P		MS	Impens et al., 2010
250	cathepsin D	2-363	P		MS	Impens et al., 2010
250	cathepsin E	2-363	P		MS	Impens et al., 2010
251	cathepsin E	2-363	P		MS	Impens et al., 2010
270	cathepsin E	2-363	P		MS	Impens et al., 2010
362	carboxypeptidase A6	355-363	N		MS	Lyons et al., 2008