Structure for peptidase homologue S09.980: cholinesterase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

 

TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Drosophila melanogaster
mature  peptidase 2.70 Å 1DX4 1DX4 1DX4 1DX4 1DX4 1DX4 Harel et al., 2000
mature  peptidase 2.70 Å 1QO9 1QO9 1QO9 1QO9 1QO9 1QO9 Harel et al., 2000
mature  peptidase 2.72 Å 1QON 1QON 1QON 1QON 1QON 1QON Harel et al., 2000
Homo sapiens
mature  peptidase 0.00 Å 1EHO 1EHO 1EHO 1EHO 1EHO 1EHO
mature  peptidase 0.00 Å 1EHQ 1EHQ 1EHQ 1EHQ 1EHQ 1EHQ
mature  peptidase 0.00 Å 1KCJ 1KCJ 1KCJ 1KCJ 1KCJ 1KCJ
mature  peptidase 2.00 Å 1P0I 1P0I 1P0I 1P0I 1P0I 1P0I Nicolet et al., 2003
mature  peptidase 2.38 Å 1P0M 1P0M 1P0M 1P0M 1P0M 1P0M Nicolet et al., 2003
mature  peptidase 2.30 Å 1P0P 1P0P 1P0P 1P0P 1P0P 1P0P Nicolet et al., 2003
mature  peptidase 2.43 Å 1P0Q 1P0Q 1P0Q 1P0Q 1P0Q 1P0Q Nicolet et al., 2003
mature  peptidase 2.20 Å 1XLU 1XLU 1XLU 1XLU 1XLU 1XLU Nachon et al., 2005
mature  peptidase 2.25 Å 1XLV 1XLV 1XLV 1XLV 1XLV 1XLV Nachon et al., 2005
mature  peptidase 2.10 Å 1XLW 1XLW 1XLW 1XLW 1XLW 1XLW Nachon et al., 2005
mature  peptidase 2.75 Å 2J4C 2J4C 2J4C 2J4C 2J4C 2J4C Frasco et al., 2007
mature  peptidase 2.80 Å 2PM8 2PM8 2PM8 2PM8 2PM8 2PM8 Ngamelue et al., 2007
mature  peptidase 2.30 Å 2WID 2WID 2WID 2WID 2WID 2WID Carletti et al., 2009
mature  peptidase 2.25 Å 2WIF 2WIF 2WIF 2WIF 2WIF 2WIF Carletti et al., 2009
mature  peptidase 2.15 Å 2WIG 2WIG 2WIG 2WIG 2WIG 2WIG Carletti et al., 2009
mature  peptidase 2.10 Å 2WIJ 2WIJ 2WIJ 2WIJ 2WIJ 2WIJ Carletti et al., 2009
mature  peptidase 2.10 Å 2WIK 2WIK 2WIK 2WIK 2WIK 2WIK Carletti et al., 2009
mature  peptidase 3.10 Å 2WIL 2WIL 2WIL 2WIL 2WIL 2WIL Carletti et al., 2009
mature  peptidase 2.00 Å 2WSL 2WSL 2WSL 2WSL 2WSL 2WSL Carletti et al., 2009
mature  peptidase 2.10 Å 2XMB 2XMB 2XMB 2XMB 2XMB 2XMB Nachon et al., 2011
mature  peptidase 2.40 Å 2XMC 2XMC 2XMC 2XMC 2XMC 2XMC Nachon et al., 2011
mature  peptidase 2.30 Å 2XMD 2XMD 2XMD 2XMD 2XMD 2XMD Nachon et al., 2011
mature  peptidase 2.70 Å 2XMG 2XMG 2XMG 2XMG 2XMG 2XMG Nachon et al., 2011
mature  peptidase 2.10 Å 2XQF 2XQF 2XQF 2XQF 2XQF 2XQF Wandhammer et al., 2011
mature  peptidase 2.30 Å 2XQG 2XQG 2XQG 2XQG 2XQG 2XQG Wandhammer et al., 2011
mature  peptidase 2.60 Å 2XQI 2XQI 2XQI 2XQI 2XQI 2XQI Wandhammer et al., 2011
mature  peptidase 2.40 Å 2XQJ 2XQJ 2XQJ 2XQJ 2XQJ 2XQJ Wandhammer et al., 2011
mature  peptidase 2.40 Å 2XQK 2XQK 2XQK 2XQK 2XQK 2XQK Wandhammer et al., 2011
mature  peptidase 2.50 Å 2Y1K 2Y1K 2Y1K 2Y1K 2Y1K 2Y1K Carletti et al., 2011
mature  peptidase 2.10 Å 3DJY 3DJY 3DJY 3DJY 3DJY 3DJY Carletti et al., 2008
mature  peptidase 2.31 Å 3DKK 3DKK 3DKK 3DKK 3DKK 3DKK Carletti et al., 2008
mature  peptidase 2.98 Å 3O9M 3O9M 3O9M 3O9M 3O9M 3O9M Asojo et al., 2011
mature  peptidase 2.50 Å 4AQD 4AQD 4AQD 4AQD 4AQD 4AQD Brazzolotto et al., 2012
mature  peptidase 2.40 Å 4AXB 4AXB 4AXB 4AXB 4AXB 4AXB Wandhammer et al., 2013
mature  peptidase 2.35 Å 4B0O 4B0O 4B0O 4B0O 4B0O 4B0O Wandhammer et al., 2013
mature  peptidase 2.50 Å 4B0P 4B0P 4B0P 4B0P 4B0P 4B0P Wandhammer et al., 2013
mature  peptidase 2.70 Å 4BBZ 4BBZ 4BBZ 4BBZ 4BBZ 4BBZ Carletti et al., 2013
mature  peptidase 2.10 Å 4BDS 4BDS 4BDS 4BDS 4BDS 4BDS Nachon et al., 2013
mature  peptidase 2.70 Å 4TPK 4TPK 4TPK 4TPK 4TPK 4TPK Brus et al., 2014
mature  peptidase 2.70 Å 4XII 4XII 4XII 4XII 4XII 4XII Knez et al., 2015
complex with n- ((1-benzylpiperidin-3-yl)methyl)-n-methylnaphthalene-2-sulfonamide ***caveat 5dyt nag a 606 has wrong chirality at atom c1 nag a 607 has wrong ***caveat 2 5dyt chirality at atom c1 nag a 2.55 Å 5DYT 5DYT 5DYT 5DYT 5DYT 5DYT
complex with n- ((1-benzylpiperidin-3-yl)methyl)-n-(2-methoxyethyl)naphthalene-2- sulfonamide ***caveat 5dyw 5hf a 601 has wrong chirality at atom c07 nag a 621 has ***caveat 2 5dyw wrong chirality at at 2.50 Å 5DYW 5DYW 5DYW 5DYW 5DYW 5DYW
complex with n- ((1-benzylpiperidin-3-yl)methyl)naphthalene-2-sulfonamide ***caveat 5dyy nag a 611 has wrong chirality at atom c1 nag a 612 has wrong ***caveat 2 5dyy chirality at atom c1 ful a 613 has w 2.65 Å 5DYY 5DYY 5DYY 5DYY 5DYY 5DYY
discovery and structure-activity relationships of a highly selective butyrylcholinesterase inhibitor by structure-based virtual screening 2.80 Å 5K5E 5K5E 5K5E 5K5E 5K5E 5K5E
complex with N-propargyliperidines 2.52 Å 5LKR 5LKR 5LKR 5LKR 5LKR 5LKR
crystal structure of hubche with n-((1-(2,3-dihydro-1h-inden-2-yl) piperidin-3-yl)methyl)-n-(2-(dimethylamino)ethyl)-2-naphthamide. ***caveat 5nn0 fuc a 605 has wrong chirality at atom c1 nag a 608 has wrong ***caveat 2 5nn0 chirality at atom c1 2.10 Å 5NN0 5NN0 5NN0 5NN0 5NN0 5NN0
crystal structure of a variant of human butyrylcholinesterase expressed in bacteria. 2.48 Å 6EMI 6EMI 6EMI 6EMI 6EMI 6EMI
complex with decamethonium 2.30 Å 6EP4 6EP4 6EP4 6EP4 6EP4 6EP4
complex with ethopropazine 2.35 Å 6EQP 6EQP 6EQP 6EQP 6EQP 6EQP
complex with huprine 19 2.40 Å 6EQQ 6EQQ 6EQQ 6EQQ 6EQQ 6EQQ
complex with propidium 2.98 Å 6ESJ 6ESJ 6ESJ 6ESJ 6ESJ 6ESJ
complex with thioflavine t 2.80 Å 6ESY 6ESY 6ESY 6ESY 6ESY 6ESY
butyrylcolinesterase expressed in cho cells co-crystallised with a rivastigmine analogue 2.60 Å 6EUL 6EUL 6EUL 6EUL 6EUL 6EUL
butyrylcolinesterase expressed in cho cells co-crystallised with a rivastigmine analogue 2.60 Å 6EYF 6EYF 6EYF 6EYF 6EYF 6EYF
human butyrylcholinesterase carbamylated. 2.70 Å 6EZ2 6EZ2 6EZ2 6EZ2 6EZ2 6EZ2
complex with n-propargyliperidines 2.60 Å 6F7Q 6F7Q 6F7Q 6F7Q 6F7Q 6F7Q
complex with the s enantiomer of a chlorotacrine-tryptophan multi-target inhibitor. 2.38 Å 6I0B 6I0B 6I0B 6I0B 6I0B 6I0B
complex with the r enantiomer of a chlorotacrine-tryptophan multi-target inhibitor. 2.68 Å 6I0C 6I0C 6I0C 6I0C 6I0C 6I0C
cryoem reconstruction of full-length, fully-glycosylated human butyrylcholinesterase tetramer 5.70 Å 6I2T 6I2T 6I2T 6I2T 6I2T 6I2T
complex with (s)-2-(butylamino)-n-(2- cycloheptylethyl)-3-(1h-indol-3-yl)propanamide 1.90 Å 6QAA 6QAA 6QAA 6QAA 6QAA 6QAA
complex with (s)-n-(1-((2- cycloheptylethyl)amino)-3-(1h-indol-3-yl)-1-oxopropan-2-yl)-n,n- dimethylbutan-1-aminium 2.49 Å 6QAB 6QAB 6QAB 6QAB 6QAB 6QAB
complex with (s)-2-(butylamino)-n-(3- cycloheptylpropyl)-3-(1h-indol-3-yl)propanamide 2.77 Å 6QAC 6QAC 6QAC 6QAC 6QAC 6QAC
complex with ((s)-2-(butylamino)-n-(2- (4-(dimethylamino)cyclohexyl)ethyl)-3-(1h-indol-3-yl)propanamide 2.50 Å 6QAD 6QAD 6QAD 6QAD 6QAD 6QAD
complex with (s)-n2-butyl-n1-(2- cycloheptylethyl)-3-(1h-indol-3-yl)-n1,n2-dimethylpropane-1,2-diamine 2.49 Å 6QAE 6QAE 6QAE 6QAE 6QAE 6QAE
Torpedo californica
mature  peptidase 2.80 Å 1ACJ 1ACJ 1ACJ 1ACJ 1ACJ 1ACJ Harel et al., 1993
mature  peptidase 2.80 Å 1ACL 1ACL 1ACL 1ACL 1ACL 1ACL Harel et al., 1993
mature  peptidase 2.80 Å 1AMN 1AMN 1AMN 1AMN 1AMN 1AMN
mature  peptidase 2.80 Å 1AX9 1AX9 1AX9 1AX9 1AX9 1AX9 Ravelli et al., 1998
mature  peptidase 2.60 Å 1CFJ 1CFJ 1CFJ 1CFJ 1CFJ 1CFJ Millard et al., 1999
mature  peptidase 2.30 Å 1DX6 1DX6 1DX6 1DX6 1DX6 1DX6 Greenblatt et al., 1999
mature  peptidase 2.85 Å 1E3Q 1E3Q 1E3Q 1E3Q 1E3Q 1E3Q Felder et al., 2002
mature  peptidase 2.10 Å 1E66 1E66 1E66 1E66 1E66 1E66 Dvir et al., 2002
mature  peptidase 1.80 Å 1EA5 1EA5 1EA5 1EA5 1EA5 1EA5 Dvir et al., 2002
mature  peptidase 4.50 Å 1EEA 1EEA 1EEA 1EEA 1EEA 1EEA
mature  peptidase 2.50 Å 1EVE 1EVE 1EVE 1EVE 1EVE 1EVE Kryger et al., 1999
mature  peptidase 3.00 Å 1FSS 1FSS 1FSS 1FSS 1FSS 1FSS Harel et al., 1995
mature  peptidase 2.10 Å 1GPK 1GPK 1GPK 1GPK 1GPK 1GPK Dvir et al., 2002
mature  peptidase 2.35 Å 1GPN 1GPN 1GPN 1GPN 1GPN 1GPN Dvir et al., 2002
mature  peptidase 2.20 Å 1GQR 1GQR 1GQR 1GQR 1GQR 1GQR Bar-On et al., 2002
mature  peptidase 3.00 Å 1GQS 1GQS 1GQS 1GQS 1GQS 1GQS Bar-On et al., 2002
mature  peptidase 2.15 Å 1H22 1H22 1H22 1H22 1H22 1H22 Wong et al., 2003
mature  peptidase 2.15 Å 1H23 1H23 1H23 1H23 1H23 1H23 Wong et al., 2003
mature  peptidase 2.50 Å 1HBJ 1HBJ 1HBJ 1HBJ 1HBJ 1HBJ Doucet-Personeni et al., 2001
mature  peptidase 0.00 Å 1JGA 1JGA 1JGA 1JGA 1JGA 1JGA
mature  peptidase 0.00 Å 1JGB 1JGB 1JGB 1JGB 1JGB 1JGB
mature  peptidase 2.30 Å 1JJB 1JJB 1JJB 1JJB 1JJB 1JJB Koellner et al., 2002
mature  peptidase 2.70 Å 1OCE 1OCE 1OCE 1OCE 1OCE 1OCE Bartolucci et al., 1999
mature  peptidase 2.20 Å 1ODC 1ODC 1ODC 1ODC 1ODC 1ODC Rydberg et al., 2006
mature  peptidase 2.05 Å 1QID 1QID 1QID 1QID 1QID 1QID Weik et al., 2000
mature  peptidase 2.10 Å 1QIE 1QIE 1QIE 1QIE 1QIE 1QIE Weik et al., 2000
mature  peptidase 2.10 Å 1QIF 1QIF 1QIF 1QIF 1QIF 1QIF Weik et al., 2000
mature  peptidase 2.30 Å 1QIG 1QIG 1QIG 1QIG 1QIG 1QIG Weik et al., 2000
mature  peptidase 2.50 Å 1QIH 1QIH 1QIH 1QIH 1QIH 1QIH Weik et al., 2000
mature  peptidase 2.65 Å 1QII 1QII 1QII 1QII 1QII 1QII Weik et al., 2000
mature  peptidase 2.80 Å 1QIJ 1QIJ 1QIJ 1QIJ 1QIJ 1QIJ Weik et al., 2000
mature  peptidase 2.90 Å 1QIK 1QIK 1QIK 1QIK 1QIK 1QIK Weik et al., 2000
mature  peptidase 3.00 Å 1QIM 1QIM 1QIM 1QIM 1QIM 1QIM Weik et al., 2000
mature  peptidase 2.50 Å 1QTI 1QTI 1QTI 1QTI 1QTI 1QTI Bartolucci et al., 2001
mature  peptidase 2.20 Å 1SOM 1SOM 1SOM 1SOM 1SOM 1SOM Millard et al., 1999
mature  peptidase 2.61 Å 1U65 1U65 1U65 1U65 1U65 1U65 Harel et al., 2005
mature  peptidase 2.40 Å 1UT6 1UT6 1UT6 1UT6 1UT6 1UT6 Rydberg et al., 2006
mature  peptidase 2.50 Å 1VOT 1VOT 1VOT 1VOT 1VOT 1VOT Raves et al., 1997
mature  peptidase 2.40 Å 1VXO 1VXO 1VXO 1VXO 1VXO 1VXO
mature  peptidase 2.20 Å 1VXR 1VXR 1VXR 1VXR 1VXR 1VXR
mature  peptidase 2.16 Å 1W4L 1W4L 1W4L 1W4L 1W4L 1W4L Greenblatt et al., 2004
mature  peptidase 2.05 Å 1W6R 1W6R 1W6R 1W6R 1W6R 1W6R Greenblatt et al., 2004
mature  peptidase 2.40 Å 1W75 1W75 1W75 1W75 1W75 1W75 Greenblatt et al., 2004
mature  peptidase 2.30 Å 1W76 1W76 1W76 1W76 1W76 1W76 Greenblatt et al., 2004
mature  peptidase 2.30 Å 1ZGB 1ZGB 1ZGB 1ZGB 1ZGB 1ZGB Haviv et al., 2005
mature  peptidase 2.10 Å 1ZGC 1ZGC 1ZGC 1ZGC 1ZGC 1ZGC Haviv et al., 2005
mature  peptidase 2.50 Å 2ACE 2ACE 2ACE 2ACE 2ACE 2ACE Raves et al., 1997
mature  peptidase 2.40 Å 2ACK 2ACK 2ACK 2ACK 2ACK 2ACK Ravelli et al., 1998
mature  peptidase 2.40 Å 2BAG 2BAG 2BAG 2BAG 2BAG 2BAG Bartolucci et al., 2006
mature  peptidase 2.15 Å 2C4H 2C4H 2C4H 2C4H 2C4H 2C4H Colletier et al., 2006
mature  peptidase 2.30 Å 2C58 2C58 2C58 2C58 2C58 2C58 Colletier et al., 2006
mature  peptidase 2.60 Å 2C5F 2C5F 2C5F 2C5F 2C5F 2C5F Colletier et al., 2006
mature  peptidase 1.95 Å 2C5G 2C5G 2C5G 2C5G 2C5G 2C5G Colletier et al., 2006
mature  peptidase 2.20 Å 2CEK 2CEK 2CEK 2CEK 2CEK 2CEK Colletier et al., 2006
mature  peptidase 2.15 Å 2CKM 2CKM 2CKM 2CKM 2CKM 2CKM Rydberg et al., 2006
mature  peptidase 2.50 Å 2CMF 2CMF 2CMF 2CMF 2CMF 2CMF Rydberg et al., 2006
mature  peptidase 2.30 Å 2DFP 2DFP 2DFP 2DFP 2DFP 2DFP Millard et al., 1999
mature  peptidase 2.60 Å 2J3D 2J3D 2J3D 2J3D 2J3D 2J3D
mature  peptidase 2.80 Å 2J3Q 2J3Q 2J3Q 2J3Q 2J3Q 2J3Q Harel et al., 2008
mature  peptidase 2.80 Å 2J4F 2J4F 2J4F 2J4F 2J4F 2J4F Kreimer et al., 1994
mature  peptidase 2.40 Å 2V96 2V96 2V96 2V96 2V96 2V96 Colletier et al., 2007
mature  peptidase 2.40 Å 2V97 2V97 2V97 2V97 2V97 2V97 Colletier et al., 2007
mature  peptidase 3.00 Å 2V98 2V98 2V98 2V98 2V98 2V98 Colletier et al., 2007
mature  peptidase 2.40 Å 2VA9 2VA9 2VA9 2VA9 2VA9 2VA9 Colletier et al., 2007
mature  peptidase 2.30 Å 2VJA 2VJA 2VJA 2VJA 2VJA 2VJA Colletier et al., 2008
mature  peptidase 2.39 Å 2VJB 2VJB 2VJB 2VJB 2VJB 2VJB Colletier et al., 2008
mature  peptidase 2.20 Å 2VJC 2VJC 2VJC 2VJC 2VJC 2VJC Colletier et al., 2008
mature  peptidase 2.30 Å 2VJD 2VJD 2VJD 2VJD 2VJD 2VJD Colletier et al., 2008
mature  peptidase 2.71 Å 2VQ6 2VQ6 2VQ6 2VQ6 2VQ6 2VQ6
mature  peptidase 2.40 Å 2VT6 2VT6 2VT6 2VT6 2VT6 2VT6 Colletier et al., 2008
mature  peptidase 2.20 Å 2VT7 2VT7 2VT7 2VT7 2VT7 2VT7 Colletier et al., 2008
mature  peptidase 2.69 Å 2W6C 2W6C 2W6C 2W6C 2W6C 2W6C Paz et al., 2009
mature  peptidase 2.43 Å 2W9I 2W9I 2W9I 2W9I 2W9I 2W9I Paz et al., 2012
mature  peptidase 1.95 Å 2WFZ 2WFZ 2WFZ 2WFZ 2WFZ 2WFZ Sanson et al., 2009
mature  peptidase 2.20 Å 2WG0 2WG0 2WG0 2WG0 2WG0 2WG0 Sanson et al., 2009
mature  peptidase 2.20 Å 2WG1 2WG1 2WG1 2WG1 2WG1 2WG1 Sanson et al., 2009
mature  peptidase 1.95 Å 2WG2 2WG2 2WG2 2WG2 2WG2 2WG2 Sanson et al., 2009
mature  peptidase 2.30 Å 2XI4 2XI4 2XI4 2XI4 2XI4 2XI4 Sanson et al., 2011
mature  peptidase 0.00 Å 3ACE 3ACE 3ACE 3ACE 3ACE 3ACE
mature  peptidase 2.39 Å 3GEL 3GEL 3GEL 3GEL 3GEL 3GEL
mature  peptidase 2.26 Å 3I6M 3I6M 3I6M 3I6M 3I6M 3I6M Bartolucci et al., 2010
mature  peptidase 2.19 Å 3I6Z 3I6Z 3I6Z 3I6Z 3I6Z 3I6Z Bartolucci et al., 2010
mature  peptidase 2.34 Å 3M3D 3M3D 3M3D 3M3D 3M3D 3M3D
mature  peptidase 2.26 Å 3ZV7 3ZV7 3ZV7 3ZV7 3ZV7 3ZV7 Bartolucci et al., 2012
mature  peptidase 0.00 Å 4ACE 4ACE 4ACE 4ACE 4ACE 4ACE
mature  peptidase 2.30 Å 4TVK 4TVK 4TVK 4TVK 4TVK 4TVK Nepovimova et al., 2014
mature  peptidase 2.80 Å 4W63 4W63 4W63 4W63 4W63 4W63
mature  peptidase 2.60 Å 4X3C 4X3C 4X3C 4X3C 4X3C 4X3C
mature  peptidase 2.57 Å 5BWB 5BWB 5BWB 5BWB 5BWB 5BWB Legler et al., 2015
mature  peptidase 2.45 Å 5BWC 5BWC 5BWC 5BWC 5BWC 5BWC Legler et al., 2015
acetylcholinesterase methylene blue no peg 2.70 Å 5DLP 5DLP 5DLP 5DLP 5DLP 5DLP
mature  peptidase 2.65 Å 5E2I 5E2I 5E2I 5E2I 5E2I 5E2I
acetylcholinesterase methylene blue no peg 2.54 Å 5E4J 5E4J 5E4J 5E4J 5E4J 5E4J
acetylcholinesterase methylene blue with peg 2.43 Å 5E4T 5E4T 5E4T 5E4T 5E4T 5E4T
crystal structure of msf-aged torpedo californica acetylcholinesterase 2.10 Å 5EHX 5EHX 5EHX 5EHX 5EHX 5EHX
complex with alkylene-linked bis-tacrine dimer (7 carbon linker) 2.10 Å 5EI5 5EI5 5EI5 5EI5 5EI5 5EI5
complex with the n- methyl-indoxylacetate hydrolysis products 2.40 Å 5IH7 5IH7 5IH7 5IH7 5IH7 5IH7
torpedo californica acetylcholinesterase in complex with a non-chiral donepezil-like inhibitor 17 2.17 Å 5NAP 5NAP 5NAP 5NAP 5NAP 5NAP
torpedo californica acetylcholinesterase in complex with a non-chiral donepezil-like compound 20 2.25 Å 5NAU 5NAU 5NAU 5NAU 5NAU 5NAU
torpedo californica acetylcholinesterase in complex with a chlorotacrine-tryptophan hybrid inhibitor 2.50 Å 5NUU 5NUU 5NUU 5NUU 5NUU 5NUU
rivastigmine analogue bound to tc ache. 2.00 Å 6EUE 6EUE 6EUE 6EUE 6EUE 6EUE
t. californica ache in complex with a 3-hydroxy-2-pyridine aldoxime. 2.22 Å 6EWK 6EWK 6EWK 6EWK 6EWK 6EWK
torpedo californica ache in complex with indolic multi-target directedligand 2.20 Å 6EZG 6EZG 6EZG 6EZG 6EZG 6EZG
torpedo californica ache in complex with indolic multi-target directedligand ***caveat 6ezh nag a 601 has wrong chirality at atom c1 2.60 Å 6EZH 6EZH 6EZH 6EZH 6EZH 6EZH
carbamylated t. californica acetylcholineterase bound to uncharged hybrid reactivator 1 2.40 Å 6FLD 6FLD 6FLD 6FLD 6FLD 6FLD
carbamylated t. californica acetylcholineterase bound to uncharged hybrid reactivator 2 2.30 Å 6FQN 6FQN 6FQN 6FQN 6FQN 6FQN
non-aged form of torpedo californica acetylcholinesterase inhibited bynerve agent tabun 2.20 Å 6G17 6G17 6G17 6G17 6G17 6G17
complex with 9-amino-6-chloro-1,2,3,4-tetrahydro-10-methylacridin-10-ium 1.79 Å 6G1U 6G1U 6G1U 6G1U 6G1U 6G1U
complex with 12-amino-3-chloro-6,7,10,11-tetrahydro-5,9-dimethyl-7, 11-methanocycloocta[b]quinolin-5-ium 1.82 Å 6G1V 6G1V 6G1V 6G1V 6G1V 6G1V
complex with 2-1-[2-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino) ethyl]-1h-1,2,3-triazol-4-yl-n-[4-(hydroxy)-3- methoxybenzyl]acetamide 1.90 Å 6G1W 6G1W 6G1W 6G1W 6G1W 6G1W
torpedo californica acetylcholinesterase bound to uncharged hybrid reactivator 1 2.63 Å 6G4M 6G4M 6G4M 6G4M 6G4M 6G4M
torpedo californica acetylcholinesterase bound to uncharged hybrid reactivator 2 2.90 Å 6G4N 6G4N 6G4N 6G4N 6G4N 6G4N
non-aged form of torpedo californica acetylcholinesterase inhibited bytabun analog nedpa bound to uncharged reactivator 1 2.78 Å 6G4O 6G4O 6G4O 6G4O 6G4O 6G4O
non-aged form of torpedo californica acetylcholinesterase inhibited bytabun analog nedpa bound to uncharged reactivator 2 2.83 Å 6G4P 6G4P 6G4P 6G4P 6G4P 6G4P
complex to 1-(6-oxo-1,2,3,4,6,10b- hexahydropyrido[2,1-a]isoindol-10-yl)-3-(4-(((1-(2-((1,2,3,4- tetrahydroacridin-9-yl)amino)ethyl)-1h-1,2,3-triazol-4-yl)methoxy) methyl)pyridin-2-yl)urea ***caveat 6h12 fjk a 626 has wrong c 2.20 Å 6H12 6H12 6H12 6H12 6H12 6H12
complex to1-(4-((methyl((1-(2-((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl)-1h-1,2,3-triazol-4-yl)methyl) amino)methyl)pyridin-2-yl)-3-(6-oxo-1,2,3,4,6,10b-hexahydropyrido[2, 1-a]isoindol-10-yl)urea ***caveat 6h13 nag a 602 h 2.80 Å 6H13 6H13 6H13 6H13 6H13 6H13
complex to 1-(6-oxo-1,2,3,4,6,10b- hexahydropyrido[2,1-a]isoindol-10-yl)-3-(4-(1-(2-((1,2,3,4- tetrahydroacridin-9-yl)amino)ethyl)-1h-1,2,3-triazol-4-yl)pyridin-2- yl)urea 1.86 Å 6H14 6H14 6H14 6H14 6H14 6H14