PDBe 2xmg

X-ray diffraction
2.7Å resolution

G117H mutant of human butyrylcholinesterase in complex with VX

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cholinesterase Chain: A
Molecule details ›
Chain: A
Length: 529 amino acids
Theoretical weight: 59.79 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P06276 (Residues: 29-557; Coverage: 92%)
Gene names: BCHE, CHE1
Sequence domains: Carboxylesterase family
Structure domains: Rossmann fold

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: I422
Unit cell:
a: 156.57Å b: 156.57Å c: 128.39Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.176 0.25
Expression system: Cricetulus griseus