PDBe 5dyw

X-ray diffraction
2.5Å resolution

Crystal structure of human butyrylcholinesterase in complex with N-((1-benzylpiperidin-3-yl)methyl)-N-(2-methoxyethyl)naphthalene-2-sulfonamide


Function and Biology Details

Reaction catalysed:
An acylcholine + H(2)O = choline + a carboxylate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Cholinesterase Chains: A, B
Molecule details ›
Chains: A, B
Length: 530 amino acids
Theoretical weight: 59.76 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
  • Canonical: P06276 (Residues: 28-557; Coverage: 92%)
Gene names: BCHE, CHE1
Sequence domains: Carboxylesterase family
Structure domains: Rossmann fold

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 72.214Å b: 78.863Å c: 226.65Å
α: 90° β: 90° γ: 90°
R R work R free
0.191 0.19 0.216
Expression system: Drosophila melanogaster