PDBe 4tpk

X-ray diffraction
2.7Å resolution

Human butyrylcholinesterase in complex with N-((1-(2,3-dihydro-1H-inden-2-yl)piperidin-3-yl)methyl)-N-(2-methoxyethyl)-2-naphthamide

Released:

Function and Biology Details

Reaction catalysed:
An acylcholine + H(2)O = choline + a carboxylate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cholinesterase Chains: A, B
Molecule details ›
Chains: A, B
Length: 602 amino acids
Theoretical weight: 68.49 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P06276 (Residues: 1-602; Coverage: 100%)
Gene names: BCHE, CHE1
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 76.6Å b: 80.2Å c: 231.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.239
Expression system: Cricetulus griseus