Substrates for peptidase M12.020: ADAM28 peptidase (mouse-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
insulin-like growth factor-binding protein 3	P17936	28-291	peptide-Arg124+Ala-peptide	P	NT	Ser	Arg	Leu	Arg	Ala	Tyr	Leu	Leu	Mochizuki et al., 2004
myelin basic protein	P02687	1-169	peptide-Ala17+Ser-peptide	P		Leu	Ala	Ser	Ala	Ser	Thr	Met	Asp	Blobel, 2004	16711
myelin basic protein	P02687	1-169	peptide-Ala63+Arg-peptide	P		His	His	Ala	Ala	Arg	Thr	Thr	His	Blobel, 2004	16712
myelin basic protein	P02687	1-169	peptide-Pro72+Gln-peptide	P		Gly	Ser	Leu	Pro	Gln	Lys	Ala	Gln	Blobel, 2004	16714
myelin basic protein	P02687	1-169	peptide-Arg107+Gly-peptide	P		Gly	Lys	Gly	Arg	Gly	Leu	Ser	Leu	Blobel, 2004	16713