Substrates for peptidase M12.224: ADAM28 peptidase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
connective tissue growth factor	P29279	27-349	peptide-Ala181+Tyr-peptide	P	NT	Ala	Leu	Ala	Ala	Tyr	Arg	Leu	Glu	Mochizuki et al., 2004
connective tissue growth factor	P29279	27-349	peptide-Asp191+Pro-peptide	P	NT	Phe	Gly	Pro	Asp	Pro	Thr	Met	Ile	Mochizuki et al., 2004
insulin-like growth factor-binding protein 3	P17936	28-291	peptide-Arg124+Ala-peptide	P	NT	Ser	Arg	Leu	Arg	Ala	Tyr	Leu	Leu	Mochizuki et al., 2004
myelin basic protein	P02687	1-169	peptide-Ala16+Ser-peptide	N		Leu	Ala	Ser	Ala	Ser	Thr	Met	Asp	Howard et al., 2001
myelin basic protein	P02687	1-169	peptide-Pro71+Gln-peptide	N		Gly	Ser	Leu	Pro	Gln	Lys	Ala	Gln	Howard et al., 2001
myelin basic protein	P02687	1-169	peptide-Arg106+Gly-peptide	N		Gly	Lys	Gly	Arg	Gly	Leu	Ser	Leu	Howard et al., 2001