Substrates for peptidase S01.244: kallikrein-related peptidase 8

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Boc-Ala-Gly-Pro-Arg-NHMec			Boc-Ala-Gly-Pro-Arg+NHMec	S		Ala	Gly	Pro	Arg	AMC	-	-	-	Shimizu et al., 1998
Boc-Asp-Pro-Arg-NHMec			Boc-Asp-Pro-Arg+NHMec	S		Boc	Asp	Pro	Arg	AMC	-	-	-	Shimizu et al., 1998
Boc-Glt-Gly-Arg-NHMec			Boc-Glt-Gly-Arg+NHMec	S		Boc	Glt	Gly	Arg	AMC	-	-	-	Shimizu et al., 1998
Boc-Glu-Gly-Arg-NHMec			Boc-Glu-Gly-Arg+NHMec	S		Boc	Glu	Gly	Arg	AMC	-	-	-	Shimizu et al., 1998
Boc-Glu-Lys-Lys-NHMec			Boc-Glu-Lys-Lys+NHMec	S		Boc	Glu	Lys	Lys	AMC	-	-	-	Shimizu et al., 1998
Boc-Gly-Arg-Arg-NHMec			Boc-Gly-Arg-Arg+NHMec	S		Boc	Gly	Arg	Arg	AMC	-	-	-	Shimizu et al., 1998
Boc-Leu-Arg-Arg-NHMec			Boc-Leu-Arg-Arg+NHMec	S		Boc	Leu	Arg	Arg	AMC	-	-	-	Shimizu et al., 1998
Boc-Leu-Thr-Arg-NHMec			Boc-Leu-Thr-Arg+NHMec	S		Boc	Leu	Thr	Arg	AMC	-	-	-	Shimizu et al., 1998
Boc-Phe-Ser-Arg-NHMec			Boc-Phe-Ser-Arg+NHMec	S		Boc	Phe	Ser	Arg	AMC	-	-	-	Shimizu et al., 1998
Boc-Pyr-Gly-Arg-NHMec			Boc-Pyr-Gly-Arg+NHMec	S		Boc	Pyr	Gly	Arg	AMC	-	-	-	Shimizu et al., 1998
Boc-Val-Pro-Arg-NHMec			Boc-Val-Pro-Arg+NHMec	S		Boc	Val	Pro	Arg	AMC	-	-	-	Shimizu et al., 1998
D-Val-Leu-Arg-NHPhNO2			D-Val-Leu-Arg+NHPhNO2	S		-	DVa	Leu	Arg	NAN	-	-	-	Shimizu et al., 1998
D-Val-Leu-Lys-NHPhNO2			D-Val-Leu-Lys+NHPhNO2	S		D	Val	Leu	Lys	NAN	-	-	-	Shimizu et al., 1998
fibronectin	P02751	32-2386	peptide-Arg290+Ala-peptide	N		Thr	Asp	Val	Arg	Ala	Ala	Val	Tyr	Shimizu et al., 1998	20727
Kallikrein-1 precursor	P06870	19-262	peptide-Arg24+Ile-peptide	P	NT	Ile	Gln	Ser	Arg	Ile	Val	Gly	Gly	Yoon et al., 2007
Kallikrein-11 precursor	Q9UBX7	51-282	Glu-Thr-Arg53+Ile-peptide	P	NT	-	Glu	Thr	Arg	Ile	Ile	Lys	Gly	Yoon et al., 2007
Kallikrein-12 precursor	Q9UKR0	18-248	Ala-Thr-Pro-Lys21+Ile-peptide	P	NT	Ala	Thr	Pro	Lys	Ile	Phe	Asn	Gly	Yoon et al., 2007
Kallikrein-2 precursor	P20151	19-261	peptide-Arg24+Ile-peptide	P	NT	Ile	Gln	Ser	Arg	Ile	Val	Gly	Gly	Yoon et al., 2007
Kallikrein-5 precursor	Q9Y337	23-293	peptide-Arg66+Ile-peptide	P	NT	Ser	Ser	Ser	Arg	Ile	Ile	Asn	Gly	Yoon et al., 2007
Kallikrein-6 precursor	Q92876	17-244	peptide-Lys21+Leu-peptide	P	NT	Glu	Gln	Asn	Lys	Leu	Val	His	Gly	Yoon et al., 2007
Kallikrein-9 precursor	Q9UKQ9	16-250	peptide-Arg22+Ala-peptide	P	NT	Ala	Asp	Thr	Arg	Ala	Ile	Gly	Ala	Yoon et al., 2007
Prostate-specific antigen precursor	P07288	18-261	peptide-Arg24+Ile-peptide	P	NT	Ile	Leu	Ser	Arg	Ile	Val	Gly	Gly	Yoon et al., 2007
Somatotropin	P01241	27-217	Peptide-Arg160+Thr-Peptide	P	NT	Gly	Ser	Pro	Arg	Thr	Gly	Gln	Ile	Komatsu et al., 2007
tissue-type plasminogen activator	P00750	36-562	peptide-Arg310+Ile-peptide	P	NT	Pro	Gln	Phe	Arg	Ile	Lys	Gly	Gly	Rajapakse et al., 2005
Z-Pro-Phe-Arg-NHPhNO2			Z-Pro-Phe-Arg+NHPhNO2	S		Z	Pro	Phe	Arg	NAN	-	-	-	Shimizu et al., 1998