Substrates for peptidase M43.007: ulilysin (Methanosarcina acetivorans)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Dabcyl-Leu-Ala-Arg-Val-Glu(EDANS)			Dabcyl-Leu-Ala+Arg-Val-Glu-EDANS	S	-	Dab	Leu	Ala	Arg	Val	Glu	Ens	Tallant et al., 2007
fibrinogen alpha chain	P02671	36-866	peptide-Glu41+Arg-peptide	N	Arg	Val	Val	Glu	Arg	His	Gln	Ser	Tallant et al., 2006
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu+Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	Val	Cya	Gly	Glu	Arg	Gly	Phe	Phe	Tallant et al., 2006
Raymond-peptide 1			ANG-Lys-Asp-Glu-Ser-Tyr+Arg-DNK	S	Asp	Glu	Ser	Tyr	Arg	DNK	-	-	Tallant et al., 2007
Raymond-peptide 2			ANG-Ala-Val-Pro-Glu+Arg-DNK	S	Ala	Val	Pro	Glu	Arg	DNK	-	-	Tallant et al., 2007
Raymond-peptide 4			ANG-Tyr-Ala+Arg-Lys-Leu-Phe-DNK	S	-	ANG	Tyr	Ala	Arg	Lys	Leu	Phe	Tallant et al., 2007
ulilysin precursor	Q8TL28	1-342	peptide-Ser60+Arg-peptide	P	Arg	Ala	Ile	Ser	Arg	Met	Glu	Ile	Tallant et al., 2006
ulilysin precursor	Q8TL28	1-342	peptide-Ala322+Arg-peptide	P	Ser	Phe	Leu	Ala	Arg	Val	Glu	Glu	Tallant et al., 2006