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Substrates for peptidase S01.015: tryptase beta

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ac-Arg-Asn-Arg-NHMec Ac-Arg-Asn-Arg+NHMec S Ac Arg Asn Arg AMC - - - Yuan et al., 2006
Ac-Lys-Ala-Lys-NHMec Ac-Lys-Ala-Lys-NHMec S Ac Lys Ala Lys AMC - - - Yuan et al., 2006
Ac-Orn-Asn-Arg-NHMec Ac-Orn-Asn-Arg-NHMec S Ac Orn Asn Arg AMC - - - Yuan et al., 2006
Ac-Orn-Asn-Lys-NHMec Ac-Orn-Asn-Lys-NHMec S Ac Orn Asn Lys AMC - - - Yuan et al., 2006
Ac-Orn-Phe-Arg-NHMec Ac-Orn-Phe-Arg+NHMec S Ac Orn Phe Arg AMC - - - Yuan et al., 2006
Ac-Orn-Trp-Arg-NHMec Ac-Orn-Trp-Arg+NHMec S Ac Orn Trp Arg AMC - - - Yuan et al., 2006
Ac-Orn-Tyr-Arg-NHMec Ac-Orn-Tyr-Arg+NHMec S Ac Orn Tyr Arg AMC - - - Yuan et al., 2006
Ac-Pro-Ala-Asn-Lys-ACC Ac-Pro-Ala-Asn-Lys+ACC S Pro Ala Asn Lys ACC - - - Harris et al., 2001
Ac-Pro-Ala-Asn-Lys-ACC Ac-Pro-Ala-Asn-Lys+ACC S Pro Ala Asn Lys ACC - - - Harris et al., 2001
Ac-Pro-Arg-Asn-Arg-ACC Ac-Pro-Arg-Asn-Arg+ACC S Pro Arg Asn Arg ACC - - - Harris et al., 2001
Ac-Pro-Arg-Asn-Arg-ACC Ac-Pro-Arg-Asn-Arg+ACC S Pro Arg Asn Arg ACC - - - Harris et al., 2001
Ac-Pro-Arg-Asn-Lys-ACC Ac-Pro-Arg-Asn-Lys+ACC S Pro Arg Asn Lys ACC - - - Harris et al., 2001
Ac-Pro-Arg-Asn-Lys-ACC Ac-Pro-Arg-Asn-Lys+ACC S Pro Arg Asn Lys ACC - - - Harris et al., 2001
Ac-Pro-Arg-Thr-Lys-ACC Ac-Pro-Arg-Thr-Lys+ACC S Pro Arg Thr Lys ACC - - - Harris et al., 2001
Ac-Pro-Arg-Thr-Lys-ACC Ac-Pro-Arg-Thr-Lys+ACC S Pro Arg Thr Lys ACC - - - Harris et al., 2001
Bz-Arg-NHPhNO2 (BAPNA) Bz-Arg+NHPhNO2 S - - Bz Arg NAN - - - Caughey, 2004
Bz-Arg-NHPhNO2 (BAPNA) Bz-Arg+NHPhNO2 S - - Bz Arg NAN - - - Caughey, 2004
cathelicidin antimicrobial peptide P49913 134-170 peptide-Lys145+Ile-peptide P Ser Lys Glu Lys Ile Gly Lys Glu Schiemann et al., 2009 26846
cathelicidin antimicrobial peptide P49913 134-170 peptide-Arg152+Ile-peptide P Glu Phe Lys Arg Ile Val Gln Arg Schiemann et al., 2009 26847
cathelicidin antimicrobial peptide P49913 134-170 peptide-Arg162+Asn-peptide P Asp Phe Leu Arg Asn Leu Val Pro Schiemann et al., 2009 26845
fibrinogen alpha chain P02671 36-866 peptide-Arg591+Gly-peptide P Ser Tyr Asn Arg Gly Asp Ser Thr Thomas et al., 1998 3613
major allergen phl p V O81341 26-312 peptide-Lys58+Ala-peptide P Pro Ala Gly Lys Ala Thr Thr Glu Rauter et al., 2006 27059
major allergen phl p V O81341 26-312 peptide-Lys65+Leu-peptide P Glu Glu Gln Lys Leu Ile Glu Lys Rauter et al., 2006 27060
major allergen phl p V O81341 26-312 peptide-Lys69+Ile-peptide P Leu Ile Glu Lys Ile Asn Ala Gly Rauter et al., 2006 27061
major allergen phl p V O81341 26-312 peptide-Lys75+Ala-peptide P Ala Gly Phe Lys Ala Ala Leu Ala Rauter et al., 2006 27062
major allergen phl p V O81341 26-312 peptide-Lys89+Tyr-peptide P Pro Ala Asp Lys Tyr Arg Thr Phe Rauter et al., 2006 27063
major allergen phl p V O81341 26-312 peptide-Arg91+Thr-peptide P Asp Lys Tyr Arg Thr Phe Val Ala Rauter et al., 2006 27064
major allergen phl p V O81341 26-312 peptide-Lys103+Ala-peptide P Ala Ser Asn Lys Ala Phe Ala Glu Rauter et al., 2006 27065
major allergen phl p V O81341 26-312 peptide-Lys114+Gly-peptide P Gly Glu Pro Lys Gly Ala Ala Glu Rauter et al., 2006 27066
major allergen phl p V O81341 26-312 peptide-Lys122+Ala-peptide P Ser Ser Ser Lys Ala Ala Leu Thr Rauter et al., 2006 27067
major allergen phl p V O81341 26-312 peptide-Lys128+Leu-peptide P Leu Thr Ser Lys Leu Asp Ala Ala Rauter et al., 2006 27068
major allergen phl p V O81341 26-312 peptide-Lys134+Leu-peptide P Ala Ala Tyr Lys Leu Ala Tyr Lys Rauter et al., 2006 27069
major allergen phl p V O81341 26-312 peptide-Lys138+Thr-peptide P Leu Ala Tyr Lys Thr Ala Glu Gly Rauter et al., 2006 27070
major allergen phl p V O81341 26-312 peptide-Lys148+Tyr-peptide P Pro Glu Ala Lys Tyr Asp Ala Tyr Rauter et al., 2006 27071
major allergen phl p V O81341 26-312 peptide-Lys180+Val-peptide P Glu Glu Val Lys Val Ile Pro Ala Rauter et al., 2006 27072
major allergen phl p V O81341 26-312 peptide-Lys192+Val-peptide P Val Ile Glu Lys Val Asp Ala Ala Rauter et al., 2006 27073
major allergen phl p V O81341 26-312 peptide-Lys198+Val-peptide P Ala Ala Phe Lys Val Ala Ala Thr Rauter et al., 2006 27074
major allergen phl p V O81341 26-312 peptide-Lys212+Phe-peptide P Ala Asn Asp Lys Phe Thr Val Phe Rauter et al., 2006 27075
major allergen phl p V O81341 26-312 peptide-Lys225+Ala-peptide P Asp Ala Ile Lys Ala Ser Thr Gly Rauter et al., 2006 27076
major allergen phl p V O81341 26-312 peptide-Lys236+Phe-peptide P Glu Ser Tyr Lys Phe Ile Pro Ala Rauter et al., 2006 27077
major allergen phl p V O81341 26-312 peptide-Lys246+Gln-peptide P Ala Ala Val Lys Gln Ala Tyr Ala Rauter et al., 2006 27078
major allergen phl p V O81341 26-312 peptide-Lys260+Tyr-peptide P Pro Glu Val Lys Tyr Thr Val Phe Rauter et al., 2006 27079
major allergen phl p V O81341 26-312 peptide-Lys269+Lys-peptide P Thr Ala Leu Lys Lys Ala Ile Thr Rauter et al., 2006 27080
major allergen phl p V O81341 26-312 peptide-Lys280+Ala-peptide P Glu Ala Gln Lys Ala Ala Lys Pro Rauter et al., 2006 27081
major allergen phl p V O81341 26-312 peptide-Lys311+Val-peptide P Gly Gly Tyr Lys Val Gly Gly Gly Rauter et al., 2006 27082
major allergen phl p V O81341 26-312 peptide-Lys270+Ala-peptide P Ala Leu Lys Lys Ala Ile Thr Ala Rauter et al., 2006 27083
pollen allergen Phl p 1 P43213 24-263 peptide-Lys45+Ser-peptide P Leu Asp Ala Lys Ser Thr Trp Tyr Rauter et al., 2006 27044
pollen allergen Phl p 1 P43213 24-263 peptide-Lys58+Asp-peptide P Ala Gly Pro Lys Asp Asn Gly Gly Rauter et al., 2006 27045
pollen allergen Phl p 1 P43213 24-263 peptide-Lys140+Lys-peptide P Ala Met Ala Lys Lys Gly Asp Glu Rauter et al., 2006 27046
pollen allergen Phl p 1 P43213 24-263 peptide-Arg148+Ser-peptide P Gln Lys Leu Arg Ser Ala Gly Glu Rauter et al., 2006 27047
pollen allergen Phl p 1 P43213 24-263 peptide-Arg158+Arg-peptide P Leu Gln Phe Arg Arg Val Lys Cys Rauter et al., 2006 27048
pollen allergen Phl p 1 P43213 24-263 peptide-Lys169+Val-peptide P Glu Gly Thr Lys Val Thr Phe His Rauter et al., 2006 27049
pollen allergen Phl p 1 P43213 24-263 peptide-Lys176+Gly-peptide P His Val Glu Lys Gly Ser Asn Pro Rauter et al., 2006 27050
pollen allergen Phl p 1 P43213 24-263 peptide-Lys188+Tyr-peptide P Leu Leu Val Lys Tyr Val Asn Gly Rauter et al., 2006 27051
pollen allergen Phl p 1 P43213 24-263 peptide-Lys204+Gly-peptide P Ile Lys Glu Lys Gly Lys Asp Lys Rauter et al., 2006 27052
pollen allergen Phl p 1 P43213 24-263 peptide-Lys213+Glu-peptide P Ile Glu Leu Lys Glu Ser Trp Gly Rauter et al., 2006 27053
pollen allergen Phl p 1 P43213 24-263 peptide-Arg221+Ile-peptide P Ala Ile Trp Arg Ile Asp Thr Pro Rauter et al., 2006 27054
pollen allergen Phl p 1 P43213 24-263 peptide-Lys227+Leu-peptide P Thr Pro Asp Lys Leu Thr Gly Pro Rauter et al., 2006 27055
pollen allergen Phl p 1 P43213 24-263 peptide-Arg235+Tyr-peptide P Phe Thr Val Arg Tyr Thr Thr Glu Rauter et al., 2006 27056
pollen allergen Phl p 1 P43213 24-263 peptide-Lys243+Thr-peptide P Gly Gly Thr Lys Thr Glu Ala Glu Rauter et al., 2006 27057
pollen allergen Phl p 1 P43213 24-263 peptide-Lys255+Ala-peptide P Glu Gly Trp Lys Ala Asp Thr Ser Rauter et al., 2006 27058
tryptase inhibitor precursor Q1EG59 22-118 peptide-Arg30+Arg-peptide P Val Glu Glu Arg Arg Asn Arg Pro Paesen et al., 2007
tryptase inhibitor precursor Q1EG59 22-118 peptide-Arg107+His-peptide P Phe Arg Pro Arg His Gly Leu Glu Paesen et al., 2007
Z-Ala-Lys-Arg-NHMec Z-Ala-Lys-Arg+NHMec S Z Ala Lys Arg AMC - - - Caughey, 2004
Z-Ala-Lys-Arg-NHMec Z-Ala-Lys-Arg+NHMec S Z Ala Lys Arg AMC - - - Caughey, 2004

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