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Peptidase

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Substrates for peptidase A01.020: phytepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
ac-Phe-Tyr(I2) ac-Phe+Tyr(I2) S - - Ac Phe Tyi - - - Kulkarni & Rao, 2007
Alpha-lactalbumin P00711 1-142 Peptide-Phe28+Arg-Peptide N NT Cys Glu Val Phe Arg Glu Leu Lys Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Gly54+Tyr-Peptide N NT His Thr Ser Gly Tyr Asp Thr Gln Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Ala59+Ile-Peptide N NT Asp Thr Gln Ala Ile Val Gln Asn Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Leu71+Phe-Peptide N NT Glu Tyr Gly Leu Phe Gln Ile Asn Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Leu104+Thr-Peptide N NT Asp Asp Asp Leu Thr Asp Asp Ile Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Ala19+Glu-Peptide N NT Ala Thr Gln Ala Glu Gln Leu Thr Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Glu30+Leu-Peptide N NT Val Phe Arg Glu Leu Lys Asp Leu Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Tyr37+Gly-Peptide N NT Leu Lys Gly Tyr Gly Gly Val Ser Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Trp45+Val-Peptide N NT Leu Pro Glu Trp Val Cys Thr Thr Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Phe50+His-Peptide N NT Cys Thr Thr Phe His Thr Ser Gly Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Ser66+Thr-Peptide N NT Asn Asn Asp Ser Thr Glu Tyr Gly Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Phe72+Gln-Peptide N NT Tyr Gly Leu Phe Gln Ile Asn Asn Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Gln73+Ile-Peptide N NT Gly Leu Phe Gln Ile Asn Asn Lys Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Ile78+Trp-Peptide N NT Asn Asn Lys Ile Trp Cys Lys Asp Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Leu115+Asp-Peptide N NT Lys Lys Ile Leu Asp Lys Val Gly Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Leu124+Ala-Peptide N NT Asn Tyr Trp Leu Ala His Lys Ala Barros & Malcata, 2006
Alpha-lactalbumin P00711 1-142 Peptide-Phe28+Arg-Peptide N Cys Glu Val Phe Arg Glu Leu Lys Barros & Malcata, 2006
alpha-S1-casein P02662 16-214 peptide-Phe23+Phe-peptide N Leu Leu Arg Phe Phe Val Ala Pro Pires, 1998
alpha-S1-casein P02662 16-214 peptide-Trp164+Tyr-peptide N Ser Gly Ala Trp Tyr Tyr Val Pro Pires, 1998
alpha-S1-casein P02662 16-214 peptide-Trp164+Tyr-peptide N Ser Gly Ala Trp Tyr Tyr Val Pro Pires, 1998
alpha-S1-casein P02662 16-214 peptide-Phe153+Tyr-peptide N Leu Ala Tyr Phe Tyr Pro Glu Leu Pires, 1998
alpha-S1-casein P02662 16-214 peptide-Phe23+Phe-peptide N Leu Leu Arg Phe Phe Val Ala Pro Pires, 1998 15874
alpha-S1-casein P02662 16-214 peptide-Trp164+Tyr-peptide N Ser Gly Ala Trp Tyr Tyr Val Pro Pires, 1998 15876
alpha-S1-casein P02662 16-214 peptide-Phe153+Tyr-peptide N Leu Ala Tyr Phe Tyr Pro Glu Leu Pires, 1998 15872
alpha-S1-casein P02662 16-214 peptide-Phe150+Arg-peptide N Pro Glu Leu Phe Arg Gln Phe Tyr Pires, 1998 15871
Aspartic proteinase Q9SSZ1 314-418 Peptide-Asn379+Asp-Peptide P NT Ala Gly Leu Asn Asp Gly Ile Cys Park et al., 2001
Aspartic proteinase Q9SSZ1 314-418 Peptide-Ala339+Gln-Peptide P NT Leu Ser Glu Ala Gln Pro Asp Lys Park et al., 2001
Aspartic proteinase Q9SSZ1 314-418 Peptide-Asn411+Glu-Peptide P NT Asn Tyr Val Asn Glu Leu Cys Asp Park et al., 2001
Aspartic proteinase Q9SSZ1 314-418 Gly-Val315+Met-Peptide P NT - - Gly Val Met Ser Gln Gln Park et al., 2001
Aspartic proteinase Q9SSZ1 314-418 Gly-Val-Met316+Ser-Peptide P NT - Gly Val Met Ser Gln Gln Cys Park et al., 2001
Aspartic proteinase Q9SSZ1 314-418 Peptide-Cys414+Asp-Peptide P NT Asn Glu Leu Cys Asp Arg Ile Pro Park et al., 2001
Aspartic proteinase Q9SSZ1 314-418 Peptide-Asp415+Arg-Ile-Pro P NT Glu Leu Cys Asp Arg Ile Pro - Park et al., 2001
beta-casein P02666 16-224 peptide-Leu165+Ser-peptide N Val Leu Ser Leu Ser Gln Ser Lys Pires, 1998
beta-casein P02666 16-224 peptide-Leu192+Tyr-peptide N Ala Phe Leu Leu Tyr Gln Glu Pro Pires, 1998
beta-casein P02666 16-224 peptide-Leu127+Thr-peptide N Ser Leu Thr Leu Thr Asp Val Glu Pires, 1998 15879
beta-casein P02666 16-224 peptide-Leu192+Tyr-peptide N Ala Phe Leu Leu Tyr Gln Glu Pro Pires, 1998 15882
beta-casein P02666 16-224 peptide-Leu165+Ser-peptide N Val Leu Ser Leu Ser Gln Ser Lys Pires, 1998 15880
glucagon P01274 53-81 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp+Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N Phe Thr Ser Asp Tyr Ser Lys Tyr Kervinen et al., 2004 15884
glucagon P01274 53-81 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu+Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N Ser Lys Tyr Leu Asp Ser Arg Arg Kervinen et al., 2004 15886
glucagon P01274 53-81 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg+Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N Asp Ser Arg Arg Ala Gln Asp Phe Kervinen et al., 2004 15888
glucagon P01274 53-81 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp+Leu-Met-Asn-Thr N Phe Val Gln Trp Leu Met Asn Thr Kervinen et al., 2004 15890
glucagon P01274 53-81 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr+Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N Tyr Ser Lys Tyr Leu Asp Ser Arg Kervinen et al., 2004 15885
glucagon P01274 53-81 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser+Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr N Tyr Leu Asp Ser Arg Arg Ala Gln Kervinen et al., 2004 15887
glucagon P01274 53-81 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe+Val-Gln-Trp-Leu-Met-Asn-Thr N Ala Gln Asp Phe Val Gln Trp Leu Kervinen et al., 2004 15889
glucagon P01274 53-81 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu+Met-Asn-Thr N Val Gln Trp Leu Met Asn Thr - Kervinen et al., 2004 15891
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu+Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Gly Ser His Leu Val Glu Ala Leu Kervinen et al., 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Val Glu Ala Leu Tyr Leu Val Cya Kervinen et al., 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala N Arg Gly Phe Phe Tyr Thr Pro Lys Kervinen et al., 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N His Leu Val Glu Ala Leu Tyr Leu Pires, 1998
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Leu Val Glu Ala Leu Tyr Leu Val Kervinen et al., 2004
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala N Glu Arg Gly Phe Phe Tyr Thr Pro Kervinen et al., 2004
kappa-casein P02668 22-190 peptide-Phe105+Met-peptide N His Leu Ser Phe Met Ala Ile Pro Cordeiro et al., 1998
kappa-casein P02668 22-190 peptide-Phe105+Met-peptide N His Leu Ser Phe Met Ala Ile Pro Pires, 1998
kappa-casein P02668 22-190 peptide-Phe105+Met-peptide N His Leu Ser Phe Met Ala Ile Pro Pires, 1998 15898
Leu-Ser-Nph-Ahx-Ala-Leu-OMe Leu-Ser-Nph+Ahx-Ala-Leu-OMe S - Leu Ser Nph Ahx Ala Leu - Pires, 1998
Lys-Pro-Ala-Glu-Phe-Nph-Ala-Leu Lys-Pro-Ala-Glu-Phe+Nph-Ala-Leu S Ala Ala Glu Phe Nph Ala Leu - Pires, 1998
Lys-Pro-Ile-Leu-Phe-Nph-Arg-Leu Lys-Pro-Ile-Leu-Phe+Nph-Arg-Leu S Pro Ile Leu Phe Nph Arg Leu - Cordeiro et al., 1998
Lys-Pro-Ile-Val-Phe-Nph-Arg-Leu Lys-Pro-Ile-Val-Phe+Nph-Arg-Leu S Pro Ile Val Phe Nph Arg Leu - Cordeiro et al., 1998
Lys-Pro-Leu-Gln-Leu-Nph-Arg-Leu Lys-Pro-Leu-Gln-Leu+Nph-Arg-Leu S Pro Leu Gln Leu Nph Arg Leu - Cordeiro et al., 1998
Pro-Thr-Glu-Phe-Nph-Arg-Leu Pro-Thr-Glu-Phe+Nph-Arg-Leu N Pro Thr Glu Phe Nph Arg Leu - Kervinen et al., 2004
Pro-Thr-Glu-Phe-Nph-Arg-Leu Pro-Thr-Glu-Phe+Nph-Arg-Leu N Pro Thr Glu Phe Nph Arg Leu - Sidrach et al., 2005

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