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Peptidase

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Substrates for peptidase S08.057: thermomycolin

Summary Alignment Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ac-Ala-Ala-Ala-OCH3 Ac-Ala-Ala-Ala+OCH3 S Ac Ala Ala Ala OMe - - - Gaucher & Stevenson, 2004
glucagon P01274 53-81 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln+Trp-Leu-Met-Asn-Thr N Asp Phe Val Gln Trp Leu Met Asn Gaucher & Stevenson, 2004 17537
glucagon P01272 53-81 peptide-Gln55+Gly-peptide N - His Ser Gln Gly Thr Phe Thr Stevenson & Gaucher, 1976 24335
glucagon P01272 53-81 peptide-Thr57+Phe-peptide N Ser Gln Gly Thr Phe Thr Ser Asp Stevenson & Gaucher, 1976 24336
glucagon P01272 53-81 peptide-Phe58+Thr-peptide N Gln Gly Thr Phe Thr Ser Asp Tyr Stevenson & Gaucher, 1976 24337
glucagon P01272 53-81 peptide-Ser60+Asp-peptide N Thr Phe Thr Ser Asp Tyr Ser Lys Stevenson & Gaucher, 1976 24338
glucagon P01272 53-81 peptide-Lys64+Tyr-peptide N Asp Tyr Ser Lys Tyr Leu Asp Ser Stevenson & Gaucher, 1976 24339
glucagon P01272 53-81 peptide-Tyr65+Leu-peptide N Tyr Ser Lys Tyr Leu Asp Ser Arg Stevenson & Gaucher, 1976 24340
glucagon P01272 53-81 peptide-Leu66+Asp-peptide N Ser Lys Tyr Leu Asp Ser Arg Arg Stevenson & Gaucher, 1976 24341
glucagon P01272 53-81 peptide-Asp67+Ser-peptide N Lys Tyr Leu Asp Ser Arg Arg Ala Stevenson & Gaucher, 1976 24342
glucagon P01272 53-81 peptide-Ser68+Arg-peptide N Tyr Leu Asp Ser Arg Arg Ala Gln Stevenson & Gaucher, 1976 24343
glucagon P01272 53-81 peptide-Arg69+Arg-peptide N Leu Asp Ser Arg Arg Ala Gln Asp Stevenson & Gaucher, 1976 24344
glucagon P01272 53-81 peptide-Gln72+Asp-peptide N Arg Arg Ala Gln Asp Phe Val Gln Stevenson & Gaucher, 1976 24345
glucagon P01272 53-81 peptide-Phe74+Val-peptide N Ala Gln Asp Phe Val Gln Trp Leu Stevenson & Gaucher, 1976 24346
glucagon P01272 53-81 peptide-Trp77+Leu-peptide N Phe Val Gln Trp Leu Met Asn Thr Stevenson & Gaucher, 1976 24347
glucagon P01272 53-81 peptide-Met79+Asn-peptide N Gln Trp Leu Met Asn Thr Lys Arg Stevenson & Gaucher, 1976 24348
glucagon P01272 53-81 peptide-Leu78+Met-peptide N Val Gln Trp Leu Met Asn Thr Lys Stevenson & Gaucher, 1976 24349
glucagon P01272 53-81 His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln+Trp-Leu-Met-Asn-Thr N Asp Phe Val Gln Trp Leu Met Asn Stevenson & Gaucher, 1976
insulin A chain (oxidized) P01317 85-105 peptide-Leu97+Tyr-peptide N Val Cya Ser Leu Tyr Gln Leu Glu Stevenson & Gaucher, 1976 24333
insulin A chain (oxidized) P01317 85-105 peptide-Glu101+Asn-peptide N Tyr Gln Leu Glu Asn Tyr Cya Asn Stevenson & Gaucher, 1976 24334
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N His Leu Val Glu Ala Leu Tyr Leu Stevenson & Gaucher, 1976 24329
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N Val Glu Ala Leu Tyr Leu Val Cya Stevenson & Gaucher, 1976 24330
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala N Glu Arg Gly Phe Phe Tyr Thr Pro Stevenson & Gaucher, 1976 24331
insulin B-chain (oxidized) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr+Thr-Pro-Lys-Ala N Gly Phe Phe Tyr Thr Pro Lys Ala Stevenson & Gaucher, 1976 24332
Z-Ala-PhNO2 Z-Ala+OPhNO2 S - - Z Ala OPh - - - Gaucher & Stevenson, 2004
Z-Gly-OPhNO2 Z-Gly+OPhNO2 S - - Z Gly ONA - - - Gaucher & Stevenson, 2004
Z-Gly-Pro-Gly+Gly-Pro-Ala Z-Gly-Pro-Gly+Gly-Pro-Ala S Z Gly Pro Gly Gly Pro Ala - Gaucher & Stevenson, 2004
Z-Gly-Pro-Leu+Gly-Pro Z-Gly-Pro-Leu+Gly-Pro S Z Gly Pro Leu Gly Pro - - Gaucher & Stevenson, 2004

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