Substrates for peptidase A01.003: gastricsin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ac-Phe-Leu-Val-His			Ac-Phe+Leu-Val-His	S		-	Ac	Phe	Phe	Leu	Val	His	-	Tang, 2004
Ac-Phe-Leu-Val-His-NH2			Ac-Phe+Leu-Val-His-NH2	S		-	Ac	Phe	Phe	Leu	Val	NH2	-	Tang, 2004
Ac-Tyr-Leu-Val-His			Ac-Tyr+Leu-Val-His	S		-	-	Ac	Tyr	Leu	Val	His	-	Tang, 2004
gastricsin precursor	P20142	17-388	peptide-Phe27+Leu28-peptide	P		Leu	Gly	Glu	Phe	Leu	Arg	Thr	His	Richter et al., 1998	19051
gastricsin precursor	P20142	17-388	peptide-Leu59+Ser-peptide	P		Phe	Gly	Asp	Leu	Ser	Val	Thr	Tyr	Khan et al., 1997	19050
Glucagon	P01274	53-81	peptide-Phe58+Thr-peptide	N	NT	Gln	Gly	Thr	Phe	Thr	Ser	Asp	Tyr	Huang & Tang, 1969
Glucagon	P01274	53-81	peptide-Asp61+Tyr-peptide	N	NT	Phe	Thr	Ser	Asp	Tyr	Ser	Lys	Tyr	Huang & Tang, 1969
Glucagon	P01274	53-81	peptide-Tyr62+Ser-peptide	N	NT	Thr	Ser	Asp	Tyr	Ser	Lys	Tyr	Leu	Huang & Tang, 1969
Glucagon	P01274	53-81	peptide-Tyr65+Leu-peptide	N	NT	Tyr	Ser	Lys	Tyr	Leu	Asp	Ser	Arg	Huang & Tang, 1969
Glucagon	P01274	53-81	peptide-Phe74+Val-peptide	N	NT	Ala	Gln	Asp	Phe	Val	Gln	Trp	Leu	Huang & Tang, 1969
Glucagon	P01274	53-81	peptide-Leu78+Met-Asn-Thr	N	NT	Val	Gln	Trp	Leu	Met	Asn	Thr	-	Huang & Tang, 1969
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Cya	Gly	Ser	His	Leu	Val	Glu	Ala	Ichishima, 2004
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		His	Leu	Val	Glu	Ala	Leu	Tyr	Leu	Ichishima, 2004
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Leu	Val	Glu	Ala	Leu	Tyr	Leu	Val	Ichishima, 2004
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe+Phe-Tyr-Thr-Pro-Lys-Ala	N		Glu	Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Ichishima, 2004
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N		Glu	Ala	Leu	Tyr	Leu	Val	Cya	Gly	Ichishima, 2004
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Val	Glu	Ala	Leu	Tyr	Leu	Val	Cya	Tanji et al., 2007
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu+Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala	N	NT	Gly	Ser	His	Leu	Val	Glu	Ala	Leu	Tanji et al., 2007
insulin B-chain (oxidized)	P01317	25-54	Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe+Tyr-Thr-Pro-Lys-Ala	N	NT	Arg	Gly	Phe	Phe	Tyr	Thr	Pro	Lys	Tanji et al., 2007
kappa-casein	P02668	22-190	peptide-Phe126+Met-peptide	P		His	Leu	Ser	Phe	Met	Ala	Ile	Pro	Drohse & Foltmann, 1989
Lys-Pro-Ile-Glu-Phe-Nph-Arg-Leu			Lys-Pro-Ile-Glu-Phe+Nph-Arg-Leu	S		Pro	Ile	Glu	Phe	Nph	Arg	Leu	-	Oda et al., 1992
pulmonary surfactant-associated protein B	P07988	25-381	peptide-Leu196+Ser-peptide	P	MS	Thr	Gln	Asp	Leu	Ser	Glu	Gln	Gln	Gerson et al., 2008
pulmonary surfactant-associated protein B	P07988	25-381	peptide-Asp296+Ser-peptide	P	MS	Leu	Pro	Arg	Asp	Ser	Glu	Cys	His	Gerson et al., 2008
pulmonary surfactant-associated protein B	P07988	25-381	peptide-Met303+Ser-peptide	P	MS	His	Leu	Cys	Met	Ser	Val	Thr	Thr	Gerson et al., 2008
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Ala31+Ala-peptide	N	NT	Glu	Thr	Ala	Ala	Ala	Lys	Phe	Glu	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Phe34+Glu-peptide	N	NT	Ala	Ala	Lys	Phe	Glu	Arg	Gln	His	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Ser58+Arg-peptide	N	NT	Met	Met	Lys	Ser	Arg	Asn	Leu	Thr	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Asn60+Leu-peptide	N	NT	Lys	Ser	Arg	Asn	Leu	Thr	Lys	Asp	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Glu75+Ser-peptide	N	NT	Phe	Val	His	Glu	Ser	Leu	Ala	Asp	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Val69+Asn-peptide	N	NT	Cys	Lys	Pro	Val	Asn	Thr	Phe	Val	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Thr71+Phe-peptide	N	NT	Pro	Val	Asn	Thr	Phe	Val	His	Glu	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-His74+Glu-peptide	N	NT	Thr	Phe	Val	His	Glu	Ser	Leu	Ala	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Leu77+Ala-peptide	N	NT	His	Glu	Ser	Leu	Ala	Asp	Val	Gln	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Phe72+Val-peptide	N	NT	Val	Asn	Thr	Phe	Val	His	Glu	Ser	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Ala78+Asp-peptide	N	NT	Glu	Ser	Leu	Ala	Asp	Val	Gln	Ala	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Gln81+Ala-peptide	N	NT	Ala	Asp	Val	Gln	Ala	Val	Cys	Ser	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Gln100+Ser-peptide	N	NT	Asn	Cys	Tyr	Gln	Ser	Tyr	Ser	Thr	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Arg111+Glu-peptide	N	NT	Thr	Asp	Cys	Arg	Glu	Thr	Gly	Ser	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Ser115+Ser-peptide	N	NT	Glu	Thr	Gly	Ser	Ser	Lys	Tyr	Pro	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Met105+Ser-peptide	N	NT	Tyr	Ser	Thr	Met	Ser	Ile	Thr	Asp	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Tyr118+Pro-peptide	N	NT	Ser	Ser	Lys	Tyr	Pro	Asn	Cys	Ala	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Val144+His-peptide	N	NT	Tyr	Val	Pro	Val	His	Phe	Asp	Ala	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Phe146+Asp-Ala-Ser-Val	N	NT	Pro	Val	His	Phe	Asp	Ala	Ser	Val	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Tyr102+Ser-peptide	N	NT	Tyr	Gln	Ser	Tyr	Ser	Thr	Met	Ser	Huang & Tang, 1969
Ribonuclease pancreatic (oxidized)	P61823	27-150	peptide-Tyr99+Gln-peptide	N	NT	Thr	Asn	Cys	Tyr	Gln	Ser	Tyr	Ser	Huang & Tang, 1969
Z-Trp-Ala			Z-Trp+Ala	S		-	-	Z	Trp	Ala	-	-	-	Tang, 2004
Z-Tyr-Ala			Z-Tyr+Ala	S		-	Z	Ala	Tyr	Ala	-	-	-	Tang, 2004
Z-Tyr-Leu			Z-Tyr+Leu	S		-	Z	Leu	Tyr	Leu	-	-	-	Tang, 2004
Z-Tyr-Ser			Z-Tyr+Ser	S		-	Z	Ser	Tyr	Ser	-	-	-	Tang, 2004
Z-Tyr-Thr			Z-Tyr+Thr	S		-	Z	Thr	Tyr	Thr	-	-	-	Tang, 2004